Explanipedia

DeepSeek vs. ChatGPT: prospects and challenges Open

Inhye Jin, Jonathan A. Tangsrivimol, Erfan Darzi, Hafeez Ul Hassan Virk, Zhen Wang , et al. · 2025

Political science

DeepSeek has introduced its recent model DeepSeek-R1, showing divergence from OpenAI’s ChatGPT, suggesting an open-source alternative to users. This paper analyzes the architecture of DeepSeek-R1, mainly adopting rule-based reinforcement l…

Benefits, limits, and risks of ChatGPT in medicine Open

Jonathan A. Tangsrivimol, Erfan Darzidehkalani, Hafeez Ul Hassan Virk, Zhen Wang, Jan Egger , et al. · 2025

Computer science Medicine Psychology

ChatGPT represents a transformative technology in healthcare, with demonstrated impacts across clinical practice, medical education, and research. Studies show significant efficiency gains, including 70% reduction in administrative time fo…

ChatGPT and Medicine: Together We Embrace the AI Renaissance Open

Sean Hacking · 2024

Art

The generative artificial intelligence (AI) model ChatGPT holds transformative prospects in medicine. The development of such models has signaled the beginning of a new era where complex biological data can be made more accessible and inte…

ChatGPT and Medicine: Together We Embrace the AI Renaissance (Preprint) Open

Sean Hacking · 2023

Art Computer science

UNSTRUCTURED The generative artificial intelligence (AI) model ChatGPT holds transformative prospects in medicine. The development of such models has signaled the beginning of a new era where complex biological data can be made more acces…

Prostate-Specific Membrane Antigen Expression in Meningioma: A Promising Theranostic Target Open

Teddi Tubre, Sean Hacking, Abigail Alexander, Arlen Brickman, Ivana Delalle , et al. · 2022

Medicine

Meningioma is the most common intracranial neoplasm, yet there is no effective therapy for recurrent/refractory meningiomas after surgery and radiation. Prostate-specific membrane antigen (PSMA) is an enzyme upregulated on endothelial cell…

Microinvasive breast cancer and the role of sentinel lymph node biopsy Open

Sean Hacking, Kara-Lynne Leonard, Dongling Wu, Mara Banks, Theresa A. Graves , et al. · 2022

Medicine

Whether sentinel lymph node biopsy (SLNB) should be performed in patients with microinvasive breast cancer (MIBC) has been a matter of debate over the last decade. MIBC has a favorable prognosis and while metastasis to the axilla is rare, …

Practical Issues of Ki-67 Evaluation in Breast Cancer Clinical Practice Open

Sean Hacking, Yihong Wang · 2022

Medicine Biology

For the past several decades, markers of cellular proliferation in breast cancer have been postulated to indicate prognosis and predict benefits from antineoplastic therapies. The most common method to measure cellular proliferation by Ki-…

A Series of COVID-19 Cases With Findings in the Gastrointestinal and Hepatobiliary System Open

WU Dong-ling, Sean Hacking, Lili Lee · 2022

Medicine

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide. Most of the infected patients present with respiratory symptoms and acute lung damage. Here, we presen…

Oral administration of TRAIL-inducing small molecule ONC201/TIC10 prevents intestinal polyposis in the <i>Apc</i> <sup>min/+</sup> mouse model. Open

Venkateshwar Madka, Arielle De La Cruz, Gopal Pathuri, Janani Panneerselvam, Yuting Zhang , et al. · 2022

Medicine Chemistry

Colorectal cancer (CRC) incidence is rising globally. Hence, preventing this disease is a high priority. With this aim, we determined the CRC prevention potential of the TRAIL-inducing small molecule ONC201/TIC10 using a preclinical model …

Nature and Significance of Stromal Differentiation, PD-L1, and VISTA in GIST Open

Sean Hacking, Dongling Wu, Lili Lee, Taisia Vitkovski, Mansoor Nasim · 2021

Medicine

The role of stromal differentiation (SD), program death-ligand 1 (PD-L1), and v-domain Ig suppressor of T cell activation (VISTA) in gastrointestinal stromal tumor (GIST) is largely unknown. Looking forward, the assessment of SD and immune…

Microinvasive breast cancer and the role of sentinel lymph node biopsy Open

Sean Hacking, Dongling Wu, Mara Banks, Theresa A. Graves, Kara-Lynne Leonard , et al. · 2021

Medicine

Whether sentinel lymph node biopsy (SLNB) should be performed in patients with microinvasive breast cancer (MIBC) has been a matter of debate over the last decade. MIBC has a favorable prognosis. Metastasis to the axilla is rare in MIBC, b…

Superpixel Image Segmentation of the Tumoral Microenvironment in Colorectal Cancer: Frontiers Beyond the Microscope Open

Sean Hacking, Dongling Wu, Claudine Alexis, Mansoor Nasim · 2021

Computer science Medicine

Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal (GI) tract and accounts for 9% of all cancers. The stroma and the tumoral microenvironment represent brave new frontiers for patients with colorectal cancer. Her…

Superpixel Image Segmentation of the Tumoral Microenvironment in Colorectal Cancer: Frontiers Beyond the Microscope Open

Sean Hacking, Dongling Wu, Claudine Alexis, Mansoor Nasim · 2021

Medicine

Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal (GI) tract and accounts for 9% of all cancers. The stroma and the tumoral microenvironment represent brave new frontiers for patients with colorectal cancer. Her…

Nature and Significance of Stromal Differentiation, PD-L1, and VISTA in GIST: Shifting Current Paradigms Open

Sean Hacking, Dongling Wu, Lili Lee, Taisia Vitkovski, Hector Chavarria , et al. · 2021

Medicine Engineering

The nature and significance of stromal differentiation (SD), program death-ligand 1 (PD-L1), and v-domain Ig suppressor of T cell activation (VISTA) in gastrointestinal stromal tumor (GIST) is largely unknown. Looking forward, the assessme…

Nature and significance of stromal differentiation in carcinosarcoma (MMMT): unravelling the biology and shifting current paradigms Open

Sean Hacking, Dongling Wu, Rafae Nasim, Hector Chavarria, Mansoor Nasim · 2021

Medicine Biology

Carcinosarcoma (CS) is a rare, aggressive malignancy of the Mullerian system often termed mixed malignant Mullerian tumor (MMMT). It is biphasic in nature, differentiating into epithelial and sarcomatous components. Tumor-node-metastasis (…

Superpixel Image Segmentation of VISTA Expression in Colorectal Cancer: Implications for Immunotherapy Open

Dongling Wu, Sean Hacking, Taisia Vitkovski, Mansoor Nasim · 2020

Medicine

Colorectal cancer is an overall bad player and accounts for 9% of all cancers. Today, advancements in immune checkpoint inhibition has provided therapeutics for many, but not all cancer patients. This issue is in part due to the tumoral mi…

PD-L1/PD-1 Expression in Endometrial Clear Cell Carcinoma: A Potential Surrogate Marker for Clinical Trials Open

Cao Jin, Sean Hacking, Sharon X. Liang, Mansoor Nasim · 2019

Medicine Physics

Background. Endometrial clear cell carcinoma (ECCC) represents a rare subtype of endometrial cancer. Recently, immunotherapeutic drugs targeting programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) was associated with i…

Systemic p-ANCA vasculitis with fatal outcome, arising in the setting of methimazole use Open

Sean Hacking, Nupur N. Uppal, Neelofar Khan, Marina Ionescu, Vanesa Bijol · 2019

Medicine

Here we report a fatal case of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) due to methimazole use in a 64-year-old woman. She was initially hospitalized for abdominal pain and possible colitis, and subsequently d…

A Comparison of Death Domain-Associated Protein 6 in Different Endometrial Carcinomas Histotypes Open

Cao Jin, Sean Hacking, Miglena K. Komforti, Mansoor Nasim · 2019

Medicine Biology

Background: Death domain-associated protein 6 (DAXX) is involved in regulating apoptosis via subcellular localization. The presence of DAXX point mutations correlates well with loss of nuclear expression on immunohistochemistry (IHC). In t…

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