Explanipedia

HLA-E and NKG2A Mediate Resistance to BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer Open

Daniel Ranti, Haocheng Yu, Alex Wang, C P Bieber, Trine Strandgaard , et al. · 2024

SUMMARY Bacillus Calmette-Guérin (BCG) is the first-line therapy for high-grade non-muscle-invasive bladder cancer (NMIBC), yet many patients experience recurrence due to immune evasion. We identify HLA-E and NKG2A as mediators of adaptive…

Clusters of long COVID among patients hospitalized for COVID-19 in New York City Open

Sara Venkatraman, Jesus Maria Gomez Salinero, Adina Scheinfeld, Sean Houghton, David Redmond , et al. · 2024

Author Correction: Identification of SARS-CoV-2 inhibitors using lung and colonic organoids Open

Yuling Han, Xiaohua Duan, Liuliu Yang, Benjamin E. Nilsson-Payant, Pengfei Wang , et al. · 2024

Lung lymphatic endothelial cells undergo inflammatory and prothrombotic changes in a model of chronic obstructive pulmonary disease Open

Anjali Trivedi, Tyler M. Lu, Barbara D. Summers, Kihwan Kim, Alexander J. Rhee , et al. · 2024

The lymphatic vasculature regulates lung homeostasis through drainage of fluid and trafficking of immune cells and plays a key role in the response to lung injury in several disease states. We have previously shown that lymphatic dysfuncti…

Lymphatic Dysfunction Models an Autoimmune Emphysema Phenotype of Chronic Obstructive Pulmonary Disease Open

Barbara D. Summers, Kihwan Kim, Tyler M. Lu, Sean Houghton, Anjali Trivedi , et al. · 2023

Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that is characterized by many clinical phenotypes. One such phenotype of COPD is defined by emphysema, pathogenic lung tertiary lymphoid organs (TLOs), and autoantibod…

Cooperative ETS transcription factors enforce adult endothelial cell fate and cardiovascular homeostasis Open

Jesús M. Gómez-Salinero, Tomer Itkin, Sean Houghton, Chaitanya R. Badwe, Yang Lin , et al. · 2022

Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy Open

Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucía Carrau , et al. · 2022

The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis of placentas from women who tested positive at delivery showed SARS-CoV-2 genomic and subgenomic RNA in 22 out of 52 placentas. Placentas from two mo…

Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction Open

Jesús M. Gómez-Salinero, Franco Izzo, Yang Lin, Sean Houghton, Tomer Itkin , et al. · 2022

Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection Open

José M. Adrover, Lucía Carrau, Juliane Daßler‐Plenker, Yaron Bram, Vasuretha Chandar , et al. · 2022

Severe acute lung injury has few treatment options and a high mortality rate. Upon injury, neutrophils infiltrate the lungs and form neutrophil extracellular traps (NETs), damaging the lungs and driving an exacerbated immune response. Unfo…

Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2 Open

Liuliu Yang, Benjamin E. Nilsson-Payant, Yuling Han, Fabrice Jaffré, Jiajun Zhu , et al. · 2021

(Stem Cell Reports 16, 2274–2288; September 14, 2021) In the experimental procedures of the main text and in the supplemental information, the authors have now corrected the source of Golden Syrian hamsters to “Charles River” instead of “J…

SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling Open

Wei Yong Gu, Hua Wang, Xiaofeng Huang, Judith Kraiczy, Pratik Singh , et al. · 2021

Inflammatory Responses in the Placenta upon SARS-CoV-2 Infection Late in Pregnancy - IHC data Open

Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucía Carrau , et al. · 2021

SARS-CoV-2 infection during pregnancy does not affect the large majority of neonates but presents an increased risk for adverse pregnancy outcome. The effects of SARS-CoV-2 of its recently identified variants on placental function are not …

Inflammatory Responses in the Placenta upon SARS-CoV-2 Infection Late in Pregnancy - IHC data Open

Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucía Carrau , et al. · 2021

SARS-CoV-2 infection during pregnancy does not affect the large majority of neonates but presents an increased risk for adverse pregnancy outcome. The effects of SARS-CoV-2 of its recently identified variants on placental function are not …

Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2 Open

Liuliu Yang, Benjamin E. Nilsson-Payant, Yuling Han, Fabrice Jaffré, Jiajun Zhu , et al. · 2021

Heart injury has been reported in up to 20% of COVID-19 patients, yet the cause of myocardial histopathology remains unknown. Here, using an established in vivo hamster model, we demonstrate that SARS-CoV-2 can be detected in cardiomyocyte…

Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells: Current Controversies Open

Tyler M. Lu, José Gabriel Barcia Durán, Sean Houghton, Shahin Rafii, David Redmond , et al. · 2021

Brain microvascular endothelial cells (BMECs) possess unique properties that are crucial for many functions of the blood-brain-barrier (BBB) including maintenance of brain homeostasis and regulation of interactions between the brain and im…

Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice Open

José Gabriel Barcia Durán, Tyler M. Lu, Sean Houghton, Fuqiang Geng, Ryan Schreiner , et al. · 2021

Jak3 is the only non-promiscuous member of the Jak family of secondary messengers. Studies to date have focused on understanding and targeting the cell-autonomous role of Jak3 in immunity, while functional Jak3 expression outside the hemat…

Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate Open

Tyler M. Lu, Sean Houghton, Tarig Magdeldin, José Gabriel Barcia Durán, Andrew P. Minotti , et al. · 2021

Significance Human PSC-derived iBMECs have been generated to study disease mechanisms and drug development for neurological disorders. However, their full transcriptomic characterization is unclear, which could result in inaccurate physiol…

SARS-CoV-2 Infected Cardiomyocytes Recruit Monocytes by Secreting CCL2 Open

Shuibing Chen, Liuliu Yang, Benjamin E. Nilsson-Payant, Yuling Han, Fabrice Jaffré , et al. · 2020

Identification of SARS-CoV-2 inhibitors using lung and colonic organoids Open

Yuling Han, Xiaohua Duan, Liuliu Yang, Benjamin E. Nilsson-Payant, Pengfei Wang , et al. · 2020

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Open

Liuliu Yang, Yuling Han, Benjamin E. Nilsson-Payant, Vikas Gupta, Pengfei Wang , et al. · 2020

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids Open

Yuling Han, Liuliu Yang, Xiaohua Duan, Fuyu Duan, Benjamin E. Nilsson-Payant , et al. · 2020

Summary Paragraph The SARS-CoV-2 virus has caused already over 3.5 million COVID-19 cases and 250,000 deaths globally. There is an urgent need to create novel models to study SARS-CoV-2 using human disease-relevant cells to understand key …

In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors Open

Danny N. Khalil, Nathan Suek, Luís Felipe Campesato, Sadna Budhu, David Redmond , et al. · 2019

Irreversible T cell exhaustion limits the efficacy of programmed cell death 1 (PD-1) blockade. We observed that dual CD40-TLR4 stimulation within a single tumor restored PD-1 sensitivity and that this regimen triggered a systemic tumor-spe…

Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer Open

Hyejin Choi, Jiehui Deng, Shuai Li, Tarik Silk, Lauren Dong , et al. · 2019

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