Sean SJ Ihn
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View article: <i>N</i> -6-methyladenosine (m6A) promotes the nuclear retention of mRNAs with intact 5′ splice site motifs
<i>N</i> -6-methyladenosine (m6A) promotes the nuclear retention of mRNAs with intact 5′ splice site motifs Open
In humans, misprocessed mRNAs containing intact 5′ Splice Site (5′SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K, a component of the U1 snRNP. In S. pombe …
View article: <i>N</i> -6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5′ Splice Site Motifs
<i>N</i> -6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5′ Splice Site Motifs Open
In humans, misprocessed mRNAs containing intact 5′ Splice Site (5′SS) motifs are nuclear retained and targeted for decay by ZFC3H1, a component of the Poly(A) Exosome Targeting complex, and U1-70K, a component of the U1 snRNP. In S. pombe …
View article: TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes
TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes Open
While splicing has been shown to enhance nuclear export, it has remained unclear whether mRNAs generated from intronless genes use specific machinery to promote their export. Here, we investigate the role of the major nuclear pore basket p…