Sean Lance
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View article: The eyes have it: duret haemorrhage after traumatic subdural haematoma
The eyes have it: duret haemorrhage after traumatic subdural haematoma Open
A 51-year-old woman with no significant medical history was found collapsed at work having sustained a head strike. She was evaluated at her local hospital. Glasgow Coma Scale was 12 (E3 V3 M6). Pupils were equal and reactive. Eye movement…
View article: Safety and acceptability of clozapine and risperidone in progressive multiple sclerosis: a phase I, randomised, blinded, placebo-controlled trial
Safety and acceptability of clozapine and risperidone in progressive multiple sclerosis: a phase I, randomised, blinded, placebo-controlled trial Open
Objective Because clozapine and risperidone have been shown to reduce neuroinflammation in humans and mice, the Clozapine and Risperidone in Progressive Multiple Sclerosis (CRISP) trial was conducted to determine whether clozapine and risp…
View article: Safety and acceptability of clozapine and risperidone in progressive multiple sclerosis: a phase 1, randomized, blinded, placebo-controlled trial
Safety and acceptability of clozapine and risperidone in progressive multiple sclerosis: a phase 1, randomized, blinded, placebo-controlled trial Open
Objective Because clozapine and risperidone have been shown to reduce neuroinflammation in humans and mice, the CRISP trial was conducted to determine whether clozapine and risperidone are suitable for progressive multiple sclerosis (pMS).…
View article: Cerebellar nodulus infarction secondary to vertebral artery dissection
Cerebellar nodulus infarction secondary to vertebral artery dissection Open
A 40-year-old man with a 5-day history of posterior headache and neck discomfort presented with acute onset severe ataxia when walking across the road causing him to fall. There were no other neurological symptoms. On arrival to the emerge…
View article: A Novel CACNA1A Nonsense Variant [c.4054C>T (p.Arg<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mn mathvariant="bold-italic">1352</mml:mn></mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>)] Causing Episodic Ataxia Type 2
A Novel CACNA1A Nonsense Variant [c.4054C>T (p.Arg)] Causing Episodic Ataxia Type 2 Open
Episodic ataxia is a heterogenous group of uncommon neurological disorders characterised by recurrent episodes of vertigo, dysarthria, and ataxia for which a variety of different genetic variations have been implicated. Episodic ataxia typ…