Sean M. Post
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View article: Anexelekto (Axl)/Mer inhibitor tamnorzatinib in patients with relapsed/refractory acute myeloid leukaemia: Results from a phase I (monotherapy) and phase II (combination with venetoclax) clinical study
Anexelekto (Axl)/Mer inhibitor tamnorzatinib in patients with relapsed/refractory acute myeloid leukaemia: Results from a phase I (monotherapy) and phase II (combination with venetoclax) clinical study Open
Introduction: Relapsed/refractory (R/R) acute myeloid leukaemia (AML) is a life-threatening haematological malignancy without effective treatments. Anexelekto (Axl) and Mer receptor tyrosine kinases have emerged as important therapeutic ta…
View article: Supplementary Figures from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Supplementary Figures from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
All Supplementary Figures
View article: Hnrnpk haploinsufficiency in del(9q) Acute Myeloid Leukemia reveals targetable vulnerabilities
Hnrnpk haploinsufficiency in del(9q) Acute Myeloid Leukemia reveals targetable vulnerabilities Open
Deletion of the long arm of chromosome 9, del(9q), is a recurrent cytogenetic abnormality in AML and encompasses the HNRNPK locus at 9q21.32. hnRNP K is a multifunctional RNA- and DNA-binding protein involved in chromatin remodeling, trans…
View article: Silicone Breast Phantoms for use with Digital Imaging Elasto-Tomography Breast Cancer Screening
Silicone Breast Phantoms for use with Digital Imaging Elasto-Tomography Breast Cancer Screening Open
View article: The tumor suppressor HNRNPK induces p53-dependent nucleolar stress to drive ribosomopathies
The tumor suppressor HNRNPK induces p53-dependent nucleolar stress to drive ribosomopathies Open
The nucleolus is a membraneless organelle and an excellent stress sensor. Any changes in its architecture or composition lead to nucleolar stress, resulting in cell cycle arrest and interruption of ribosomal activity, critical factors in a…
View article: Supplementary Tables from Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Supplementary Tables from Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
All Supplementary Tables
View article: Data from Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Data from Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling of CD8+ T cells from 3 h…
View article: Supplementary Tables from Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Supplementary Tables from Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
All Supplementary Tables
View article: Supplementary Figures from Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Supplementary Figures from Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
All Supplementary Figures
View article: Supplementary Figures from Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Supplementary Figures from Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
All Supplementary Figures
View article: Comprehensive characterization of IFNγ signaling in acute myeloid leukemia reveals prognostic and therapeutic strategies
Comprehensive characterization of IFNγ signaling in acute myeloid leukemia reveals prognostic and therapeutic strategies Open
View article: S179: HNRNPK OVEREXPRESSION DRIVES NUCLEOLAR ABERRANCIES CAUSING RIBOSOMPATHIES
S179: HNRNPK OVEREXPRESSION DRIVES NUCLEOLAR ABERRANCIES CAUSING RIBOSOMPATHIES Open
Background: Protein biogenesis is a complex multistep process involving nucleoli and ribosomes. Aberrations in any step could lead to alterations in protein output. hnRNP K is an RNA binding protein (RBP) that process nascent RNAs into mat…
View article: Supplementary Figures from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Supplementary Figures from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
All Supplementary Figures
View article: Supplementary Figures from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Supplementary Figures from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
All Supplementary Figures
View article: Data from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Data from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling of CD8+<…
View article: Supplementary Figures from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Supplementary Figures from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
All Supplementary Figures
View article: Data from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Data from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling of CD8+<…
View article: Supplementary Figures from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Supplementary Figures from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
All Supplementary Figures
View article: Data from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion
Data from Single-Cell Profiling of CD8<sup>+</sup> T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion Open
Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling of CD8+<…
View article: Data from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Data from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
High levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, suggesting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. To test this hypothesis …
View article: Supplementary Figure 2 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Supplementary Figure 2 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
Supplementary Figure 2 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
View article: Supplementary Figure 1 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Supplementary Figure 1 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
Supplementary Figure 1 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
View article: Data from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Data from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
High levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, suggesting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. To test this hypothesis …
View article: Supplementary Figure 3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Supplementary Figure 3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
Supplementary Figure 3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
View article: Supplementary Figure 3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Supplementary Figure 3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
Supplementary Figure 3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
View article: Supplementary Figure 2 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Supplementary Figure 2 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
Supplementary Figure 2 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
View article: Supplementary Methods, Figure Legends 1-3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Supplementary Methods, Figure Legends 1-3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
Supplementary Methods, Figure Legends 1-3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
View article: Supplementary Table 1 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Supplementary Table 1 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
Supplementary Table 1 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
View article: Supplementary Table 1 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Supplementary Table 1 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
Supplementary Table 1 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
View article: Supplementary Methods, Figure Legends 1-3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4
Supplementary Methods, Figure Legends 1-3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4 Open
Supplementary Methods, Figure Legends 1-3 from Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4