Sean Mack
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Signaling pathways in pancreatic ductile adenocarcinoma and potential therapeutic targets Open
Pancreatic ductile adenocarcinoma (PDAC) has a dismal prognosis, with an overall 5-year survival of <10%. At present, PDAC is treated using systemic chemotherapeutic regimens, which have shown survival benefit in clinical trials. Unfortuna…
Potential therapeutic molecular targets for better outcomes for patients with lung cancer Open
Lung cancer is the leading cause of death among all types of cancers in the U.S. and worldwide. Although more treatments have continuously been made over the past 30 years, the prognosis remains the same. This is mainly due to the late sta…
Combination of PARPi and anti-PD-L1 therapies in ovarian cancer Open
Ovarian cancer affects one in 72 female patients in America, and nearly half of the females who carry a BRCA1/2 mutation will be diagnosed in their lifetime. At present, treatment options such as immune checkpoint inhibitors (ICI) and poly…
Contributing Factors to Operating Room Delays Identified from an Electronic Health Record: A Retrospective Study Open
The operating room (OR) is considered a major cost center and revenue generator for hospitals. Multiple factors contribute to OR delays and impact patient safety, patient satisfaction scores, and hospital financial performance. Reducing OR…
Coronavirus disease 2019 (COVID-19) and QTc prolongation Open
Introduction The cause-and-effect relationship of QTc prolongation in Coronavirus disease 2019 (COVID-19) patients has not been studied well. Objective We attempt to better understand the relationship of QTc prolongation in COVID-19 patien…