Sean Platton
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View article: Platton S, Sivapalaratnam S, Raheja P. Diagnosis and laboratory monitoring of acquired hemophilia A. <i>Hematology Am Soc Hematol Educ Program</i>. 2023;2023(1):11-18.
Platton S, Sivapalaratnam S, Raheja P. Diagnosis and laboratory monitoring of acquired hemophilia A. <i>Hematology Am Soc Hematol Educ Program</i>. 2023;2023(1):11-18. Open
View article: Guidelines on the investigation and management of antiphospholipid syndrome
Guidelines on the investigation and management of antiphospholipid syndrome Open
View article: Every minute counts: A comparison of thawing times and haemostatic quality of plasma thawed at <scp>37°C</scp> and <scp>45°C</scp> using four different methods
Every minute counts: A comparison of thawing times and haemostatic quality of plasma thawed at <span>37°C</span> and <span>45°C</span> using four different methods Open
Background Having faster plasma thawing devices could be beneficial for transfusion services, as it may improve the rapid availability of thawed plasma for bleeding patients, and it might remove the need to have extended pre‐thawed plasma:…
View article: Guideline for laboratory diagnosis and monitoring of von Willebrand disease: A joint guideline from the United Kingdom Haemophilia Centre Doctors' Organisation and the British Society for Haematology
Guideline for laboratory diagnosis and monitoring of von Willebrand disease: A joint guideline from the United Kingdom Haemophilia Centre Doctors' Organisation and the British Society for Haematology Open
This guideline updates the previous guidelines1, 2 published on behalf of the British Society for Haematology (BSH) and the United Kingdom Haemophilia Centre Doctors' Organisation (UKHCDO), focussing on the laboratory components of diagnos…
View article: Diagnosis and laboratory monitoring of acquired hemophilia A
Diagnosis and laboratory monitoring of acquired hemophilia A Open
Acquired hemophilia A (AHA) is a rare disorder in which autoantibodies against factor VIII (FVIII) lead to a bleeding phenotype that varies from life-threatening to no bleeding at all. Prolonged activated partial thromboplastin times (APTT…
View article: PB1126 The Use of Slope Ratio to Identify the Presence of Inhibitors in One- Stage Intrinsic Clotting Factor Assays on Sysmex CN-Series Analysers
PB1126 The Use of Slope Ratio to Identify the Presence of Inhibitors in One- Stage Intrinsic Clotting Factor Assays on Sysmex CN-Series Analysers Open
Background: In the presence of inhibitors of coagulation, clotting times in one-stage factor assays (OSFA) can be prolonged, leading to a factor levels that may be lower than the true value.Multi-dilution analysis is recommended by nationa…
View article: A new global fibrinolysis capacity assay for the sensitive detection of hyperfibrinolysis and hypofibrinogenemia in trauma patients
A new global fibrinolysis capacity assay for the sensitive detection of hyperfibrinolysis and hypofibrinogenemia in trauma patients Open
Severe trauma patients are characterized by a hyperfibrinolytic profile upon admission to the emergency department. The GFC assay is more sensitive than ROTEM in capturing hyperfibrinolysis and hypofibrinogenemia but requires further devel…
View article: Renal transplant and hemostasis: early postoperative changes in recipients and donors
Renal transplant and hemostasis: early postoperative changes in recipients and donors Open
Persistence of a hypercoagulable state was more prominent in recipients after 24 hours despite recovery in renal function and initiation of thromboprophylaxis.
View article: Effect on haemostasis of different replacement fluids during therapeutic plasma exchange—A comparative multicentre observational study
Effect on haemostasis of different replacement fluids during therapeutic plasma exchange—A comparative multicentre observational study Open
Introduction Therapeutic plasma exchange (TPE) is used for several chronic conditions with little evidence on the efficacy and safety of different choice of replacement fluid. Measurement of haemostasis, particularly in vitro thrombin gene…
View article: Automated measurement of coagulation and fibrinolytic activation markers: Outcomes in coronavirus disease 2019 (<scp>COVID</scp>‐19) patients
Automated measurement of coagulation and fibrinolytic activation markers: Outcomes in coronavirus disease 2019 (<span>COVID</span>‐19) patients Open
Background Severe coronavirus disease 2019 (COVID‐19) is characterized by marked hypoxaemia and lung oedema, often accompanied by disordered blood coagulation and fibrinolytic systems, endothelial damage and intravascular fibrin deposition…
View article: International consensus recommendations on the management of people with haemophilia B
International consensus recommendations on the management of people with haemophilia B Open
Haemophilia B is a rare X-linked genetic deficiency of coagulation factor IX (FIX) that, if untreated, can cause recurrent and disabling bleeding, potentially leading to severe arthropathy and/or life-threatening haemorrhage. Recent decade…
View article: International multicenter, multiplatform study to validate Taipan snake venom time as a lupus anticoagulant screening test with ecarin time as the confirmatory test: Communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies
International multicenter, multiplatform study to validate Taipan snake venom time as a lupus anticoagulant screening test with ecarin time as the confirmatory test: Communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies Open
View article: Evaluation of laboratory assays for anti‐platelet factor 4 antibodies after ChAdOx1 nCOV‐19 vaccination
Evaluation of laboratory assays for anti‐platelet factor 4 antibodies after ChAdOx1 nCOV‐19 vaccination Open
View article: Prothrombin complex concentrate vs. fresh frozen plasma in adult patients undergoing heart surgery – a pilot randomised controlled trial (PROPHESY trial)
Prothrombin complex concentrate vs. fresh frozen plasma in adult patients undergoing heart surgery – a pilot randomised controlled trial (PROPHESY trial) Open
Summary There is equipoise regarding the use of prothrombin complex concentrate vs. fresh frozen plasma in bleeding patients undergoing cardiac surgery. We performed a pilot randomised controlled trial to determine the recruitment rate for…
View article: Positive direct antiglobulin tests in patients with <scp>COVID</scp>‐19
Positive direct antiglobulin tests in patients with <span>COVID</span>‐19 Open
View article: Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19
Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19 Open
From New England Journal of Medicine, Bowles, L., Platton, S., Yartey, N., Dave, M., Lee, K., Hart, D.P., MacDonald, V., Green, L., Sivapalaratnam, S., Pasi, K.J. and MacCallum, P., Lupus Anticoagulant and Abnormal Coagulation Tests in Pat…
View article: A novel variant causing α2 antiplasmin deficiency: case report and experience in a UK centre
A novel variant causing α2 antiplasmin deficiency: case report and experience in a UK centre Open
The plasma serine protease inhibitor α2-antiplasmin (α2-AP, also known as plasmin inhibitor) plays a key role in controlling fibrinolysis. Congenital deficiency of α2-AP is extremely rare, with fewer than 18 cases reported worldwide (Pozzi…
View article: A multicenter study to evaluate automated platelet aggregometry on Sysmex CS‐series coagulation analyzers—preliminary findings
A multicenter study to evaluate automated platelet aggregometry on Sysmex CS‐series coagulation analyzers—preliminary findings Open
View article: Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy
Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy Open
Background Major trauma is a leading cause of morbidity and mortality worldwide with hemorrhage accounting for 40% of deaths. Acute traumatic coagulopathy exacerbates bleeding, but controversy remains over the degree to which inhibition of…
View article: Effects of rivaroxaban on routine coagulation screening tests using commonly used reagents
Effects of rivaroxaban on routine coagulation screening tests using commonly used reagents Open
Direct oral anticoagulants (DOACs) have predictable pharmacokinetics and are licensed for stroke prevention in non-valvular atrial fibrillation (SPAF) and the treatment and secondary prevention of venous thromboembolism (VTE) without the n…
View article: A computer‐based model to assess costs associated with the use of factor VIII and factor IX one‐stage and chromogenic activity assays
A computer‐based model to assess costs associated with the use of factor VIII and factor IX one‐stage and chromogenic activity assays Open