Sean R. R. Hall
YOU?
Author Swipe
View article: Feasibility of Manufacturing and Antitumor Activity of TIL for Advanced Endometrial Cancers
Feasibility of Manufacturing and Antitumor Activity of TIL for Advanced Endometrial Cancers Open
Lifileucel, a tumor-infiltrating lymphocyte (TIL) cell therapy approved for advanced melanoma, demonstrates promise for treating other solid tumors, including endometrial cancer (EC). The current study evaluates the feasibility of manufact…
View article: Transitional CXCL14<sup>+</sup> cancer‐associated fibroblasts enhance tumour metastasis and confer resistance to EGFR‐TKIs, revealing therapeutic vulnerability to filgotinib in lung adenocarcinoma
Transitional CXCL14<sup>+</sup> cancer‐associated fibroblasts enhance tumour metastasis and confer resistance to EGFR‐TKIs, revealing therapeutic vulnerability to filgotinib in lung adenocarcinoma Open
Background The heterogeneity of cancer‐associated fibroblasts (CAFs) has become a crucial focus in understanding cancer biology and treatment response, revealing distinct subpopulations with specific roles in tumor pathobiology. CAFs have …
View article: Host Serine Proteases and Antiviral Innate Immunity as Potential Therapeutic Targets in Influenza A Virus Infection-Induced COPD Exacerbations
Host Serine Proteases and Antiviral Innate Immunity as Potential Therapeutic Targets in Influenza A Virus Infection-Induced COPD Exacerbations Open
Lung manifestations of chronic obstructive pulmonary disease (COPD) are often exacerbated by influenza A virus infections; however, the underlying mechanisms remain largely unknown, and hence therapeutic options are limited. Using a physio…
View article: Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers
Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers Open
View article: Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers
Human Organ Chips Reveal New Inflammatory Bowel Disease Drivers Open
Inflammatory bowel disease (IBD) patients exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis, and cancer risk, with symptoms often being exacerbated in women during…
View article: Exacerbation of influenza virus induced lung injury by alveolar macrophages and its suppression by pyroptosis blockade in a human lung alveolus chip
Exacerbation of influenza virus induced lung injury by alveolar macrophages and its suppression by pyroptosis blockade in a human lung alveolus chip Open
Alveolar macrophages (AMs) are the major sentinel immune cells in human alveoli and play a central role in eliciting host inflammatory responses upon distal lung viral infection. Here, we incorporated peripheral human monocyte-derived macr…
View article: A human lung alveolus-on-a-chip model of acute radiation-induced lung injury
A human lung alveolus-on-a-chip model of acute radiation-induced lung injury Open
View article: 268. DEVELOPMENT OF A NOVEL ESOPHAGUS-ON-A-CHIP MODEL: A HIGH-FIDELITY PLATFORM FOR DIRECTING PERSONALIZED THERAPY IN ESOPHAGEAL ADENOCARCINOMA
268. DEVELOPMENT OF A NOVEL ESOPHAGUS-ON-A-CHIP MODEL: A HIGH-FIDELITY PLATFORM FOR DIRECTING PERSONALIZED THERAPY IN ESOPHAGEAL ADENOCARCINOMA Open
Background 80% of patients diagnosed with esophageal adenocarcinoma (EAC) die of disease. Current standard of care for EAC is systemic cytotoxic, platinum-based neoadjuvant chemotherapy followed by resection and additional rounds of chemot…
View article: Data from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer
Data from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer Open
Oncogenic activation of the FGFR pathway is frequent in lung and other cancers. However, due to drug resistance, pharmacological blockage of aberrant FGFR signaling has provided little clinical benefit in patients with FGFR-amplifie…
View article: Data from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer
Data from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer Open
Oncogenic activation of the FGFR pathway is frequent in lung and other cancers. However, due to drug resistance, pharmacological blockage of aberrant FGFR signaling has provided little clinical benefit in patients with FGFR-amplifie…
View article: supplementary dataset from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer
supplementary dataset from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer Open
supplementary dataset
View article: Supplementary Data from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer
Supplementary Data from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer Open
Supplementary figures, tables
View article: Supplementary Data from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer
Supplementary Data from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer Open
Supplementary figures, tables
View article: supplementary dataset from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer
supplementary dataset from CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for <i>FGFR1</i>-Amplified Lung Cancer Open
supplementary dataset
View article: Hemoxygenase-1 as a key mediator of acute radiation pneumonitis revealed in a human lung alveolus-on-a-chip
Hemoxygenase-1 as a key mediator of acute radiation pneumonitis revealed in a human lung alveolus-on-a-chip Open
Exposure to gamma radiation either due to environmental disasters or cancer radiotherapy can result in development of acute radiation syndrome (ARS), characterized by pneumonitis and lung fibrosis. We leveraged a microfluidic organ-on-a-ch…
View article: MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma
MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma Open
View article: Epithelial-Stromal Interactions in Barrett’s Esophagus Modeled in Human Organ Chips
Epithelial-Stromal Interactions in Barrett’s Esophagus Modeled in Human Organ Chips Open
View article: Battles against aberrant KEAP1-NRF2 signaling in lung cancer: intertwined metabolic and immune networks
Battles against aberrant KEAP1-NRF2 signaling in lung cancer: intertwined metabolic and immune networks Open
The Kelch-like ECH-associated protein 1/nuclear factor erythroid-derived 2-like 2 (KEAP1/NRF2) pathway is well recognized as a key regulator of redox homeostasis, protecting cells from oxidative stress and xenobiotics under physiological c…
View article: Multi-scale integrative analyses identify THBS2<sup>+</sup> cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma
Multi-scale integrative analyses identify THBS2<sup>+</sup> cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma Open
Rationale: Subsets of patients with early-stage lung adenocarcinoma (LUAD) have a poor post-surgical course after curative surgery. However, biomarkers stratifying this high-risk subset and molecular underpinnings underlying the agg…
View article: Therapeutic Targeting of MEK1/2 Synergizes with PARP1 Inhibitors in the Treatment of Malignant Pleural Mesothelioma
Therapeutic Targeting of MEK1/2 Synergizes with PARP1 Inhibitors in the Treatment of Malignant Pleural Mesothelioma Open
View article: Tumor-infiltrating lymphocytes are functionally inactivated by CD90+ stromal cells and reactivated by combined Ibrutinib and Rapamycin in human pleural mesothelioma
Tumor-infiltrating lymphocytes are functionally inactivated by CD90+ stromal cells and reactivated by combined Ibrutinib and Rapamycin in human pleural mesothelioma Open
Rationale: Despite evidence suggesting that the tumor microenvironment (TME) in malignant pleural mesothelioma (MPM) is linked with poor prognosis, there is a lack of studies that functionally characterize stromal cells and tumor-in…
View article: Peritumoral CD90+CD73+ cells possess immunosuppressive features in human non-small cell lung cancer
Peritumoral CD90+CD73+ cells possess immunosuppressive features in human non-small cell lung cancer Open
View article: Improving Prediction Marker Models With the Ratio of CD39+CD8+ to Total CD8+ T cells: How Good Is Good Enough?
Improving Prediction Marker Models With the Ratio of CD39+CD8+ to Total CD8+ T cells: How Good Is Good Enough? Open
View article: Smoking signature is superior to programmed death-ligand 1 expression in predicting pathological response to neoadjuvant immunotherapy in lung cancer patients
Smoking signature is superior to programmed death-ligand 1 expression in predicting pathological response to neoadjuvant immunotherapy in lung cancer patients Open
These findings suggest that CT scan-based evaluation is not able to accurately reflect the pathological response to immunotherapy and that smoking signature is a superior marker to PD-L1 expression in predicting the benefit of immunotherap…
View article: Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection
Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection Open
Lung-resident (LR) mesenchymal stem and stromal cells (MSCs) are key elements of the alveolar niche and fundamental regulators of homeostasis and regeneration. We interrogated their function during virus-induced lung injury using the highl…
View article: Pharmaco-transcriptomic correlation analysis reveals novel responsive signatures to HDAC inhibitors and identifies Dasatinib as a synergistic interactor in small-cell lung cancer
Pharmaco-transcriptomic correlation analysis reveals novel responsive signatures to HDAC inhibitors and identifies Dasatinib as a synergistic interactor in small-cell lung cancer Open
View article: Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection
Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection Open
Lung-resident (LR) mesenchymal stem and stromal cells (MSCs) are key elements of the alveolar niche and fundamental regulators of homeostasis and regeneration. We interrogated their function during virus-induced lung injury using the highl…
View article: Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5′-deoxy-5-fluorocytidine (5′-DFCR)
Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5′-deoxy-5-fluorocytidine (5′-DFCR) Open
View article: Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis
Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis Open
Escape from programmed cell death is a hallmark of cancer. In this study, we investigated the anti-apoptotic mechanisms and explored the therapeutic potential of BCL-2 homology domain-3 (BH3) mimetics in malignant pleural mesothelioma (MPM…
View article: NF2 and Canonical Hippo-YAP Pathway Define Distinct Tumor Subsets Characterized by Different Immune Deficiency and Treatment Implications in Human Pleural Mesothelioma
NF2 and Canonical Hippo-YAP Pathway Define Distinct Tumor Subsets Characterized by Different Immune Deficiency and Treatment Implications in Human Pleural Mesothelioma Open
(1) Inactivation of the tumor suppressor NF2 is believed to play a major role in the pathogenesis of malignant pleural mesothelioma (MPM) by deregulating the Hippo-YAP signaling pathway. However, NF2 has functions beyond regulation of the …