Sean Reuter
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View article: Ineffectiveness of mitoTEMPO on Cardiomyocyte S-phase Activity in TNNI3K-expressing Mice
Ineffectiveness of mitoTEMPO on Cardiomyocyte S-phase Activity in TNNI3K-expressing Mice Open
Background and Hypothesis: The limited regenerative capacity of the mammalian adult myocardium is a significant roadblock for therapeutic approaches in cardiovascular disease. Cell cycle arrest following S-phase is widely considered a prim…
View article: Cardiac Troponin I–Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation
Cardiac Troponin I–Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation Open
Background: Identifying genetic variants that affect the level of cell cycle reentry and establishing the degree of cell cycle progression in those variants could help guide development of therapeutic interventions aimed at effecting cardi…
View article: Absence of Cardiomyocyte Differentiation Following Transplantation of Adult Cardiac-Resident Sca-1 <sup>+</sup> Cells Into Infarcted Mouse Hearts
Absence of Cardiomyocyte Differentiation Following Transplantation of Adult Cardiac-Resident Sca-1 <sup>+</sup> Cells Into Infarcted Mouse Hearts Open
Although several lines of evidence suggest that the glycosyl phosphatidylinositol-anchored cell surface protein Sca-1 marks cardiac-resident stem cells, a critical analysis of the literature raises some concerns regarding their cardiomyoge…
View article: Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload
Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload Open
Induction of the cell cycle is emerging as an intervention to treat heart failure. Here, we tested the hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be beneficial during hemodynamic overload. …
View article: Electrical coupling between ventricular myocytes and myofibroblasts in the infarcted mouse heart
Electrical coupling between ventricular myocytes and myofibroblasts in the infarcted mouse heart Open
Myofibroblasts contribute to the population of electrically coupled nonmyocytes in the infarct border zone. The slower kinetics of myofibroblast voltage responses may reflect low electrical conductivity across heterocellular junctions, in …