Sean Stern
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New onset of comorbidities in people with epilepsy in a national healthcare claims database Open
Patients with uncontrolled epilepsy had a higher rate of new-onset comorbidities. These results indicated that seizure control may influence the non-seizure impacts of epilepsy.
Greater need for treatment optimization in patients with epilepsy initiating adjunctive therapy: Results of a retrospective claims analysis of antiseizure medication drug load in the United States Open
Concomitant ASM drug load increased prior to addition of new ASM, with higher increases observed among patients starting branded vs unbranded ASMs, followed by slight decreases thereafter. Total drug load increased linearly among all patie…
Sustainability of seizure reduction and seizure control with adjunctive cenobamate: Post hoc analysis of a phase 3, open‐label study Open
Objective In this post hoc analysis of a subset of patients from a long‐term, open‐label phase 3 study, we assessed ≥50%, ≥75%, ≥90%, and 100% seizure reduction and sustainability of these responses with cenobamate using a time‐to‐event an…
View article: Incidence of mental health conditions by seizure control among adults with epilepsy in the United States
Incidence of mental health conditions by seizure control among adults with epilepsy in the United States Open
Previous indicators of poor seizure control, including epilepsy-related emergent care admissions and new ASMs, predicted increased risk of new MHC events, including depression and anxiety, during the following 6-month interval in MHC-naïve…
Outcomes and costs of remote patient monitoring among patients with implanted cardiac defibrillators: An economic model based on the PREDICT RM database Open
Background Remote monitoring of implantable cardioverter‐defibrillators has been associated with reduced rates of all‐cause rehospitalizations and mortality among device recipients, but long‐term economic benefits have not been studied. Me…
Cost-effectiveness of golimumab for the treatment of patients with moderate-to-severe ulcerative colitis in Quebec using a patient level state transition microsimulation Open
Objective: To conduct cost-effectiveness analyses comparing the addition of golimumab to the standard of care (SoC) for treatment of patients with moderate-to-severe ulcerative colitis (UC) who are refractory to conventional therapies in Q…
View article: A new framework for evaluating the health impacts of treatment for Gaucher disease type 1
A new framework for evaluating the health impacts of treatment for Gaucher disease type 1 Open
NCT01136304 . Registered: May 31, 2010 (retrospectively registered).