Sean T. Bresnahan
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View article: Quantification method affects replicability of eQTL analysis, colocalization, and TWAS
Quantification method affects replicability of eQTL analysis, colocalization, and TWAS Open
eQTL mapping and TWAS are widely used to contextualize GWAS, yet the impact of RNA-seq processing choices remains unexplored. We find that RNA-seq quantification method and transcriptomic reference substantially affect eQTL detection and g…
View article: Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level
Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level Open
Background Integrating genome-wide association study (GWAS) and transcriptomic datasets can identify mediators for genetic risk of cancer. Traditional methods often are insufficient as they rely on total gene expression measures and overlo…
View article: Long-read transcriptome assembly reveals vast isoform diversity in the placenta associated with metabolic and endocrine function
Long-read transcriptome assembly reveals vast isoform diversity in the placenta associated with metabolic and endocrine function Open
The placenta plays a critical role in fetal development and mediates maternal metabolic effects on offspring health outcomes. Despite its importance, the placenta remains understudied in large-scale genomic initiatives, with most analyses …
View article: Intragenomic conflict associated with extreme phenotypic plasticity in queen-worker caste determination in honey bees (Apis mellifera)
Intragenomic conflict associated with extreme phenotypic plasticity in queen-worker caste determination in honey bees (Apis mellifera) Open
These findings suggest that parent-of-origin intragenomic conflict may influence phenotypic plasticity and may be associated with histone post-translational modifications, suggesting a "noncanonical" genomic imprinting-like system in socia…
View article: Correction to: Examining parent-of-origin effects on transcription and RNA methylation in mediating aggressive behavior in honey bees (Apis mellifera)
Correction to: Examining parent-of-origin effects on transcription and RNA methylation in mediating aggressive behavior in honey bees (Apis mellifera) Open
View article: Intragenomic conflict underlies extreme phenotypic plasticity in queen-worker caste determination in honey bees (<i>Apis mellifera</i>)
Intragenomic conflict underlies extreme phenotypic plasticity in queen-worker caste determination in honey bees (<i>Apis mellifera</i>) Open
Caste determination of honey bees ( Apis mellifera ) is a prime example of developmental plasticity, where differences in larval diet will result in identical genotypes yielding either long-lived, reproductive queens or short-lived, facult…
View article: More than mesolectic: Characterizing the nutritional niche of <i>Osmia cornifrons</i>
More than mesolectic: Characterizing the nutritional niche of <i>Osmia cornifrons</i> Open
Characterizing the nutritional needs of wild bee species is an essential step to better understanding bee biology and providing suitable supplemental forage for at‐risk species. Here, we aim to characterize the nutritional needs of a model…
View article: Beyond conflict: Kinship theory of intragenomic conflict predicts individual variation in altruistic behaviour
Beyond conflict: Kinship theory of intragenomic conflict predicts individual variation in altruistic behaviour Open
Behavioural variation is essential for animals to adapt to different social and environmental conditions. The Kinship Theory of Intragenomic Conflict (KTIC) predicts that parent‐specific alleles can support different behavioural strategies…
View article: Examining parent-of-origin effects on transcription and RNA methylation in mediating aggressive behavior in honey bees (Apis mellifera)
Examining parent-of-origin effects on transcription and RNA methylation in mediating aggressive behavior in honey bees (Apis mellifera) Open
View article: Beyond conflict: kinship theory of intragenomic conflict predicts individual variation in altruistic behavior
Beyond conflict: kinship theory of intragenomic conflict predicts individual variation in altruistic behavior Open
Studies of the genetic basis of behavioral variation have emphasized gene cooperation within networks, often overlooking gene conflicts. The Kinship Theory of Intragenomic Conflict (KTIC) proposes that conflicts can occur within genes when…
View article: Examining parent-of-origin effects on transcription and RNA methylation in mediating aggressive behavior in honey bees (Apis mellifera)
Examining parent-of-origin effects on transcription and RNA methylation in mediating aggressive behavior in honey bees (Apis mellifera) Open
Conflict between genes inherited from the mother (matrigenes) and the father (patrigenes) is predicted to arise during social interactions among offspring if these genes are not evenly distributed among offspring genotypes. This intragenom…
View article: Tissue-specific transcriptional patterns underlie seasonal phenotypes in honey bees (Apis mellifera)
Tissue-specific transcriptional patterns underlie seasonal phenotypes in honey bees (Apis mellifera) Open
Faced with adverse conditions, such as winter in temperate regions or hot and dry conditions in tropical regions, many insect species enter a state of diapause, a period of dormancy associated with a reduction or arrest of physical activit…
View article: Tissue-specific transcriptional patterns underlie seasonal phenotypes in honey bees (Apis mellifera)
Tissue-specific transcriptional patterns underlie seasonal phenotypes in honey bees (Apis mellifera) Open
Faced with adverse conditions, such as winter in temperate regions or hot and dry conditions in tropical regions, many insect species enter a state of diapause, a period of dormancy associated with a reduction or arrest of physical activit…
View article: Large Scale Dynamical Model of Macrophage/HIV Interactions
Large Scale Dynamical Model of Macrophage/HIV Interactions Open
View article: Investigating COMT Influence on the Proactive/Reactive Stress Coping Axis in Zebrafish
Investigating COMT Influence on the Proactive/Reactive Stress Coping Axis in Zebrafish Open