Sean Tighe
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View article: Processing Methods Affect Biological Properties of Amniotic Membrane Sheet Products
Processing Methods Affect Biological Properties of Amniotic Membrane Sheet Products Open
Amniotic membrane (AM) is widely used in ophthalmology because of its antiinflammatory, antiscarring, and wound healing promoting properties, which are due in part to a key matrix component, heavy chain-hyaluronan/pentraxin3. Herein, we as…
View article: Association of Treatment Duration and Clinical Outcomes in Dry Eye Treatment with Sutureless Cryopreserved Amniotic Membrane
Association of Treatment Duration and Clinical Outcomes in Dry Eye Treatment with Sutureless Cryopreserved Amniotic Membrane Open
This retrospective study suggests that a single placement of self-retained cAM for 2 days can significantly improve signs and symptoms of DED with a lasting benefit observed for up to 3 months.
View article: Fornix deepening reconstruction in conjunctivochalasis surgery
Fornix deepening reconstruction in conjunctivochalasis surgery Open
PURPOSE: To assess the extent of inferior fornix shortening in conjunctivochalasis (CCh) and to evaluate whether fornix deepening reconstruction can restore the fornix tear reservoir in patients with CCh. MATERIALS AND METHODS: This was a …
View article: Keyhole Anterior Lamellar Keratoplasty for Boston Keratoprosthesis Corneal Melt
Keyhole Anterior Lamellar Keratoplasty for Boston Keratoprosthesis Corneal Melt Open
Corneal melt remains a challenging complication of Boston keratoprosthesis (KPro) and may lead to disastrous consequences such as endophthalmitis, KPro extrusion, and permanent loss of vision. Several procedures have been suggested to repa…
View article: Successful management of chronic Blepharo-rosacea associated demodex by lid scrub with terpinen-4-ol
Successful management of chronic Blepharo-rosacea associated demodex by lid scrub with terpinen-4-ol Open
This case suggests that T4O is effective in treating chronic rosacea associated ocular demodex blepharitis.
View article: Self-retained cryopreserved amniotic membrane for treating severe corneal ulcers: a comparative, retrospective control study
Self-retained cryopreserved amniotic membrane for treating severe corneal ulcers: a comparative, retrospective control study Open
To compare the effectiveness of self- retained cryopreserved AM as an adjuvant therapy for infectious corneal ulcers. Retrospective, case–control study of 24 eyes of 24 consecutive patients with central and paracentral corneal infectious u…
View article: HC-HA/PTX3 Purified From Human Amniotic Membrane Reverts Human Corneal Fibroblasts and Myofibroblasts to Keratocytes by Activating BMP Signaling
HC-HA/PTX3 Purified From Human Amniotic Membrane Reverts Human Corneal Fibroblasts and Myofibroblasts to Keratocytes by Activating BMP Signaling Open
These findings collectively provide mechanistic understanding explaining how amniotic membrane transplantation exerts an antiscarring action. In addition, HC-HA/PTX3 and derivatives may be developed into a new biologic to treat corneal bli…
View article: <p>Self-Retained Cryopreserved Amniotic Membrane for the Management of Corneal Ulcers</p>
Self-Retained Cryopreserved Amniotic Membrane for the Management of Corneal Ulcers Open
Self-retained cAM may be a valuable, in-office treatment option for healing recalcitrant corneal ulcers of various etiologies, especially those with underlying NK. Further prospective, controlled studies are warranted.
View article: Self-Retained Cryopreserved Amniotic Membrane for the Management of Corneal Ulcers
Self-Retained Cryopreserved Amniotic Membrane for the Management of Corneal Ulcers Open
Daniel Brocks,1 Olivia G Mead,2 Sean Tighe,3,4 Scheffer CG Tseng2 1BostonSight, Needham, MA, USA; 2Ocular Surface Center and TissueTech Inc, Miami, FL, USA; 3Department of Ophthalmology, Florida International University, Miami, FL, USA; 4D…
View article: Basic science review of birth tissue uses in ophthalmology
Basic science review of birth tissue uses in ophthalmology Open
The birth tissue is predominantly comprised of amniotic membrane (AM) and umbilical cord (UC), which share the same cell origin as the fetus. These versatile biological tissues have been used to treat a wide range of conjunctival and corne…
View article: Differential Gene Expression between Limbal Niche Progenitors and Bone Marrow Derived Mesenchymal Stem Cells
Differential Gene Expression between Limbal Niche Progenitors and Bone Marrow Derived Mesenchymal Stem Cells Open
Purpose: To compare the difference in gene expression between human limbal niche cells (LNC) and bone marrow derived mesenchymal stem cells (BMMSC). Methods: LNC were isolated by collagenase and expanded in modified embryonic stem cell med…
View article: Amniotic membrane transplantation for managing dry eye and neurotrophic keratitis
Amniotic membrane transplantation for managing dry eye and neurotrophic keratitis Open
Neurotrophic keratitis (NK), a degenerative disease caused by damage to the trigeminal nerve, abolishes both tearing and blinking reflexes, thus causing the most severe forms of dry eye disease (DED). Conversely, the increasing severity of…
View article: <p>Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis</p>
Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis Open
Neurotrophic keratitis is an underdiagnosed degenerative condition induced by impairment to the corneal nerves which may lead to persistent epithelial defects and corneal blindness. Current medical and surgical treatments are only supporti…
View article: Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis
Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis Open
Hosam Sheha,1–3 Sean Tighe,2 Omar Hashem,3 Yasutaka Hayashida4 1Department of Ophthalmology, Manhattan Eye, Ear & Throat Hospital, Northwell Health, New York, NY, USA; 2Department of Ophthalmology, Florida International University Herbert …
View article: Injectable Amniotic Membrane/Umbilical Cord Particulate for Knee Osteoarthritis: A Prospective, Single-Center Pilot Study
Injectable Amniotic Membrane/Umbilical Cord Particulate for Knee Osteoarthritis: A Prospective, Single-Center Pilot Study Open
Objective To evaluate the short-term safety and effectiveness of amniotic membrane/umbilical cord particulate (AMUC) in managing pain in patients with various severities of knee osteoarthritis (OA). Design Single-center, prospective, inves…
View article: Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma Open
Trabecular meshwork ( TM ) contains a subset of adult stem cells or progenitors that can be differentiated into corneal endothelial cells, adipocytes and chondrocytes, but not osteocytes or keratocytes. Accordingly, these progenitors can b…
View article: Advances in culture, expansion and mechanistic studies of corneal endothelial cells: a systematic review
Advances in culture, expansion and mechanistic studies of corneal endothelial cells: a systematic review Open
Human corneal endothelial cells are notorious for their restricted proliferative ability in vivo and in vitro. Hence, injury or dysfunction of these cells may easily result in blindness. Currently, the only treatment is to transplant a don…
View article: Cellular Substrates for Cell-Based Tissue Engineering of Human Corneal Endothelial Cells
Cellular Substrates for Cell-Based Tissue Engineering of Human Corneal Endothelial Cells Open
Corneal endothelial tissue engineering aims to find solutions for blindness due to endothelial dysfunction. A suitable combination of endothelial cells, substrates and environmental cues should be deployed for engineering functional endoth…
View article: Efficacy of Anterior Stromal Puncture Surgery with Corneal Bandage Lens for Bullous Keratopathy
Efficacy of Anterior Stromal Puncture Surgery with Corneal Bandage Lens for Bullous Keratopathy Open
Objective: To investigate the safety and efficacy of the combination therapy of anterior stromal puncture (ASP) with bandage contact lens for bullous keratopathy (BK). Methods: Twelve cases (12 eyes) with vision acuity no better than light…
View article: Human Trabecular Meshwork Progenitors
Human Trabecular Meshwork Progenitors Open
Trabecular meshwork (TM) cells are a group of progenitors that have the ability to become adipocytes, chondrocytes and endothelial cells. Therefore, those adult corneal progenitors may be used as an effective therapy for trabecular meshwor…
View article: Engineering of Human Corneal Endothelial Cells <i>In Vitro</i>
Engineering of Human Corneal Endothelial Cells <i>In Vitro</i> Open
Human corneal endothelial cells are responsible for controlling corneal transparency, however they are notorious for their limited proliferative capability. Thus, damage to these cells may cause irreversible blindness. Currently, the only …
View article: Safety and efficacy of 4-terpineol against microorganisms associated with blepharitis and common ocular diseases
Safety and efficacy of 4-terpineol against microorganisms associated with blepharitis and common ocular diseases Open
Objective Microbial infection has been reported to cause blepharitis, conjunctivitis and keratitis. We evaluated the safety and efficacy of a foam formulation of 2% 4-terpineol (T4O) against common ocular microorganisms. Material and metho…
View article: Limbal niche cells are a potent resource of adult mesenchymal progenitors
Limbal niche cells are a potent resource of adult mesenchymal progenitors Open
Limbal niche cells located in the limbal Palisades of Vogt are mesenchymal stem cells that reside next to limbal basal epithelial cells. Limbal niche cells are progenitors that express embryonic stem cell markers such as Nanog, Nestin, Oct…
View article: Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study
Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study Open
Placement of CAM is promising to enhance the recovery of ocular surface health and reduce signs and symptoms in patients with moderate-to-severe DED.
View article: A New Isolation Method of Human Lacrimal Canaliculus Epithelial Stem Cells by Maintaining Close Association with Their Niche Cells
A New Isolation Method of Human Lacrimal Canaliculus Epithelial Stem Cells by Maintaining Close Association with Their Niche Cells Open
Purpose: To investigate whether lacrimal canaliculus epithelial stem cells (LCESC) could be isolated and expanded in vitro. Methods: The lacrimal canaliculus epithelium of 6 patients with limbal stem cell deficiency (LSCD) caused by alkali…