Sean W. Huth
YOU?
Author Swipe
View article: μMap-Interface: Temporal Photoproximity Labeling Identifies F11R as a Functional Member of the Transient Phagocytic Surfaceome
μMap-Interface: Temporal Photoproximity Labeling Identifies F11R as a Functional Member of the Transient Phagocytic Surfaceome Open
Phagocytosis is usually carried out by professional phagocytic cells in the context of pathogen response or wound healing. The transient surface proteins that regulate phagocytosis pose a challenging proteomics target; knowledge thereof co…
View article: Current advances in photocatalytic proximity labeling
Current advances in photocatalytic proximity labeling Open
View article: μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping
μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping Open
The characterization of ligand binding modes is a crucial step in the drug discovery process and is especially important in campaigns arising from phenotypic screening, where the protein target and binding mode are unknown at the outset. E…
View article: Cationic Homopolymers Inhibit Spore and Vegetative Cell Growth of <i>Clostridioides difficile</i>
Cationic Homopolymers Inhibit Spore and Vegetative Cell Growth of <i>Clostridioides difficile</i> Open
A wide range of synthetic polymers have been explored for antimicrobial activity. These materials usually contain both cationic and hydrophobic subunits because these two characteristics are prominent among host-defense peptides. Here, we …
View article: Beyond Amphiphilic Balance: Changing Subunit Stereochemistry Alters the Pore-Forming Activity of Nylon-3 Polymers
Beyond Amphiphilic Balance: Changing Subunit Stereochemistry Alters the Pore-Forming Activity of Nylon-3 Polymers Open
Amphiphilic nylon-3 polymers have been reported to mimic the biological activities of natural antimicrobial peptides, with high potency against bacteria and minimal toxicity toward eukaryotic cells. Amphiphilic balance, determined by the p…