Sean Yanik
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View article: iDC-targeting PfCSP mRNA vaccine confers superior protection against Plasmodium compared to conventional mRNA
iDC-targeting PfCSP mRNA vaccine confers superior protection against Plasmodium compared to conventional mRNA Open
Malaria resurgence in 2022 saw 249 million clinical cases and 608,000 deaths, mostly in children under five. The WHO-approved circumsporozoite protein (CSP)-targeting vaccines, RTS,S and R21, remain limited in availability. Strong humoral …
View article: Plasmodium RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion
Plasmodium RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion Open
Malaria is a global and deadly human disease caused by the apicomplexan parasites of the genus Plasmodium . Parasite proliferation within human red blood cells (RBCs) is associated with the clinical manifestations of the disease. This asex…
View article: Application of Machine Learning in a Rodent Malaria Model for Rapid, Accurate, and Consistent Parasite Counts
Application of Machine Learning in a Rodent Malaria Model for Rapid, Accurate, and Consistent Parasite Counts Open
Rodent malaria models serve as important preclinical antimalarial and vaccine testing tools. Evaluating treatment outcomes in these models often requires manually counting parasite-infected red blood cells (iRBCs), a time-consuming process…
View article: Immature dendritic cell-targeting mRNA vaccine expressing PfCSP enhances protective immune responses against Plasmodium liver infection
Immature dendritic cell-targeting mRNA vaccine expressing PfCSP enhances protective immune responses against Plasmodium liver infection Open
Resurgence in malaria has been noted in 2022 with 249 million clinical cases resulting in 608,000 deaths, mostly in children under five. Two vaccines, RTS, S, and more recently R21, targeting the circumsporozoite protein (CSP) are recommen…
View article: Application of machine learning in a rodent malaria model for rapid, accurate, and consistent parasite counts
Application of machine learning in a rodent malaria model for rapid, accurate, and consistent parasite counts Open
Rodent malaria models serve as important preclinical antimalarial and vaccine testing tools. Evaluating treatment outcomes in these models often requires manually counting parasite-infected red blood cells (iRBCs), a time-consuming process…
View article: <i>Plasmodium</i>RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion
<i>Plasmodium</i>RON11 triggers biogenesis of the merozoite rhoptry pair and is essential for erythrocyte invasion Open
Malaria is a global and deadly human disease caused by the apicomplexan parasites of the genus Plasmodium . Parasite proliferation within human red blood cells (RBC) is associated with the clinical manifestations of the disease. This asexu…
View article: Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies
Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies Open
View article: Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies
Structure guided mimicry of an essential P. falciparum receptor-ligand complex enhances cross neutralizing antibodies Open
Invasion of human red blood cells (RBCs) by Plasmodium falciparum (Pf) merozoites relies on the interaction between two parasite proteins, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) 1,2 . Antibodies to AMA1 confer l…
View article: Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities
Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities Open
Background The prognosis of patients with recurrent/refractory acute myelogenous leukemia (AML) remains poor and cell-based immunotherapies hold promise to improve outcomes. Natural Killer (NK) cells can elicit an antileukemic response via…
View article: Engineering CAR-NK cells to secrete IL15 sustains their anti-AML functionality, but is associated with systemic toxicities
Engineering CAR-NK cells to secrete IL15 sustains their anti-AML functionality, but is associated with systemic toxicities Open
Background The prognosis of patients with recurrent/refractory acute myelogenous leukemia (AML) remains poor and cell-based immunotherapies hold promise to improve outcomes. NK cells can elicit an anti-leukemic response via a repertoire of…
View article: Inside Cover: A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging (ChemBioChem 1/2017)
Inside Cover: A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging (ChemBioChem 1/2017) Open
The inside cover picture shows the concept of a new binary photocage that enables synchronous controlled release of two payloads linked to a single cage unit. This cage is based on photocleavable thioacetal ortho-nitrobenzaldehyde, and its…
View article: A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging
A Thioacetal Photocage Designed for Dual Release: Application in the Quantitation of Therapeutic Release by Synchronous Reporter Decaging Open
Despite the immense potential of existing photocaging technology, its application is limited by the paucity of advanced caging tools. Here, we report on the design of a novel thioacetal ortho ‐nitrobenzaldehyde (TNB) dual arm photocage tha…
View article: Modular Integration of Upconverting Nanocrystal–Dendrimer Composites for Folate Receptor‐Specific NIR Imaging and Light‐Triggered Drug Release
Modular Integration of Upconverting Nanocrystal–Dendrimer Composites for Folate Receptor‐Specific NIR Imaging and Light‐Triggered Drug Release Open
Upconversion nanocrystals (UCNs) display near‐infrared (NIR)‐responsive photoluminescent properties for NIR imaging and drug delivery. The development of effective strategies for UCN integration with other complementary nanostructures for …