Sebastián Dupraz
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View article: Neurovascular dynamics in the spinal cord from development to pathophysiology
Neurovascular dynamics in the spinal cord from development to pathophysiology Open
The vasculature is increasingly recognized as an active regulator of homeostasis and repair, beyond conventional roles in nutrient delivery. In the central nervous system, vascular cells adopt region-specific traits tailored to the distinc…
View article: Nanoscale dendritic shaft constrictions shape synaptic integration in fine caliber principal neuron dendrites
Nanoscale dendritic shaft constrictions shape synaptic integration in fine caliber principal neuron dendrites Open
Traditionally, theoretical studies typically described dendritic morphology as optimized for efficient synaptic voltage transfer from spines to the soma, implemented as a tubular design respecting Rall’s 3/2 rule for impedance matching at …
View article: Transplantation of dorsal root ganglia overexpressing the NaChBac sodium channel improves locomotion after complete SCI
Transplantation of dorsal root ganglia overexpressing the NaChBac sodium channel improves locomotion after complete SCI Open
View article: Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization
Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization Open
View article: Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain
Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain Open
View article: Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development
Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development Open
View article: Methods for culturing adult CNS neurons reveal a CNS conditioning effect
Methods for culturing adult CNS neurons reveal a CNS conditioning effect Open
Neuronal cultures provide a basis for reductionist insights that rely on molecular and pharmacological manipulation. However, the inability to culture mature adult CNS neurons limits our understanding of adult neuronal physiology. H…
View article: An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury
An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury Open
View article: <em>In Situ</em> Visualization of Axon Growth and Growth Cone Dynamics in Acute <em>Ex Vivo</em> Embryonic Brain Slice Cultures
<em>In Situ</em> Visualization of Axon Growth and Growth Cone Dynamics in Acute <em>Ex Vivo</em> Embryonic Brain Slice Cultures Open
During neuronal development, axons navigate the cortical environment to reach their final destinations and establish synaptic connections. Growth cones -the sensory structures located at the distal tips of developing axons- execute this pr…
View article: <em>In Situ</em> Visualization of Axon Growth and Growth Cone Dynamics in Acute <em>Ex Vivo</em> Embryonic Brain Slice Cultures
<em>In Situ</em> Visualization of Axon Growth and Growth Cone Dynamics in Acute <em>Ex Vivo</em> Embryonic Brain Slice Cultures Open
During neuronal development, axons navigate the cortical environment to reach their final destinations and establish synaptic connections. Growth cones -the sensory structures located at the distal tips of developing axons- execute this pr…
View article: RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury
RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury Open
View article: Faculty Opinions recommendation of Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration.
Faculty Opinions recommendation of Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration. Open
View article: RhoA Controls Axon Extension Independent of Specification in the Developing Brain
RhoA Controls Axon Extension Independent of Specification in the Developing Brain Open
View article: ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS
ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS Open
View article: The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system
The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system Open
The amyloid precursor protein ( APP ) is a type I transmembrane glycoprotein better known for its participation in the physiopathology of Alzheimer disease as the source of the beta amyloid fragment. However, the physiological functions of…
View article: The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS
The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS Open
View article: Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
Systemic administration of epothilone B promotes axon regeneration after spinal cord injury Open
Progress toward fixing a broken back? Axon regeneration after a spinal cord injury requires interference with neuronal mechanisms to promote axon extension and early suppression of scar formation. Microtubule stabilization could provide, i…