Sebastian F. Schoppmann
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View article: Lack of association between prior or concurrent malignancies and overall survival in gastroesophageal cancer: evidence from a large European single-center cohort
Lack of association between prior or concurrent malignancies and overall survival in gastroesophageal cancer: evidence from a large European single-center cohort Open
Background History of malignant disease is a common exclusion criterion in clinical cancer trials, yet data on the impact of cancer survivorship on outcome in gastroesophageal cancer patients are scarce. Methods Retrospective association a…
View article: Education and training of surgical residents in upper gastrointestinal surgery: a European survey
Education and training of surgical residents in upper gastrointestinal surgery: a European survey Open
Educating and training young surgeons is a complex challenge that requires a structured pathway. Upper gastrointestinal (UGI) surgery is becoming a highly attractive subspecialty, yet it is not universally recognized. Currently, there are …
View article: Lymphovascular Invasion (LVI) Correlates with Systemic Immune-Inflammation Index (SII) in Adenocarcinoma of the Gastroesophageal Junction (AEG): Implications for Prognostic Stratification
Lymphovascular Invasion (LVI) Correlates with Systemic Immune-Inflammation Index (SII) in Adenocarcinoma of the Gastroesophageal Junction (AEG): Implications for Prognostic Stratification Open
Adenocarcinoma of the gastroesophageal junction (AEG) is an aggressive cancer with rising incidence and poor long-term survival despite multimodal treatment. Reliable preoperative prognostic markers are lacking. Methods: The study is based…
View article: Austrian Society of Surgical Oncology consensus paper on the classification and treatment of anastomotic leaks after esophageal resections
Austrian Society of Surgical Oncology consensus paper on the classification and treatment of anastomotic leaks after esophageal resections Open
Summary Background Anastomotic leakage is still the most frequent cause of postoperative mortality following gastroesophageal surgery. This consensus paper contains the first classification and treatment recommendations from the Austrian S…
View article: The Milan Score is an Effective Manometric Tool to Predict Gastroesophageal Reflux in Patients With Laryngopharyngeal Symptoms
The Milan Score is an Effective Manometric Tool to Predict Gastroesophageal Reflux in Patients With Laryngopharyngeal Symptoms Open
Introduction According to Lyon 2.0, laryngopharyngeal symptoms (LPS) should undergo upfront pathophysiologic tests. The novel Milan score integrates esophagogastric junction (EGJ) morphology, ineffective esophageal motility, EGJ‐contractil…
View article: The Milan Score Predicts Objective Gastroesophageal Reflux Disease in Patients With Type 2 Esophagogastric Junction
The Milan Score Predicts Objective Gastroesophageal Reflux Disease in Patients With Type 2 Esophagogastric Junction Open
Introduction High‐resolution manometry (HRM) allows assessment of esophagogastric junction (EGJ) disruption. While type 3 EGJ predicts definitive gastroesophageal reflux disease (GERD), type 2 EGJ is less clearly implicated in GERD pathoge…
View article: Endoskopische und operative Therapie der gastroösophagealen Refluxkrankheit
Endoskopische und operative Therapie der gastroösophagealen Refluxkrankheit Open
Zusammenfassung Die gastroösophageale Refluxkrankheit (GERD) stellt nach wie vor eine klinische Herausforderung, insbesondere bei Patienten, die nicht auf eine konservative Therapie mit Protonenpumpenhemmern (PPI) ansprechen, dar. Seit Jah…
View article: Overexpression of Fibroblast Growth Factor 8 Is a Predictor of Impaired Survival in Esophageal Squamous Cell Carcinoma and Correlates with ALK/EML4 Alteration
Overexpression of Fibroblast Growth Factor 8 Is a Predictor of Impaired Survival in Esophageal Squamous Cell Carcinoma and Correlates with ALK/EML4 Alteration Open
FGF8, ALK, and EML4 have been identified as promising biomarkers in a number of malignancies. The aim of this study was to examine the prognostic role of FGF8, ALK, and EML4 in esophageal squamous cell carcinoma (ESCC). Methods: Consecutiv…
View article: Correction to: Association of family history with patient characteristics and prognosis in a large European gastroesophageal cancer cohort
Correction to: Association of family history with patient characteristics and prognosis in a large European gastroesophageal cancer cohort Open
View article: Improving treatment of people with gastro-esophageal reflux disease refractory to proton pump inhibitors
Improving treatment of people with gastro-esophageal reflux disease refractory to proton pump inhibitors Open
Proton pump inhibitors (PPIs) are the main treatment recommended and used for gastro-esophageal reflux disease (GERD). However, they fail to control symptoms in a substantial proportion of patients who have PPI-refractory GERD, which is de…
View article: Elevated fibrinogen-albumin ratio is an adverse prognostic factor for patients with primarily resected gastroesophageal adenocarcinoma
Elevated fibrinogen-albumin ratio is an adverse prognostic factor for patients with primarily resected gastroesophageal adenocarcinoma Open
View article: Association of family history with patient characteristics and prognosis in a large European gastroesophageal cancer cohort
Association of family history with patient characteristics and prognosis in a large European gastroesophageal cancer cohort Open
View article: Looking back on a gold standard: a systematic literature review of laparoscopic Nissen fundoplication as an anti-reflux treatment option
Looking back on a gold standard: a systematic literature review of laparoscopic Nissen fundoplication as an anti-reflux treatment option Open
Summary Background Laparoscopic Nissen fundoplication is considered the gold standard in surgical management of gastroesophageal reflux disease. Therefore, exhaustive scrutiny of the procedure is necessary. The aim of this study was to per…
View article: Elevated fibrinogen-albumin ratio is an adverse prognostic factor for patients with primarily resected gastroesophageal adenocarcinoma
Elevated fibrinogen-albumin ratio is an adverse prognostic factor for patients with primarily resected gastroesophageal adenocarcinoma Open
Purpose: Serum fibrinogen and albumin play important roles in systemic inflammation and are implicated in tumor progression. The fibrinogen-to-albumin ratio (FAR) has shown a prognostic impact in several malignancies. This study aims to as…
View article: Screening for oncogenic AF1q expression predicts disease recurrence in gastric cancer patients
Screening for oncogenic AF1q expression predicts disease recurrence in gastric cancer patients Open
AF1q associates with tumor progression and metastases upon WNT signaling. The downstream WNT target CD44 has demonstrated prognostic significance in gastric cancer (GC). This study evaluates the impact of AF1q on tumor stage and survival i…
View article: Multicentric short term and safety study of ineffective esophageal motility patients treated with RefluxStop device
Multicentric short term and safety study of ineffective esophageal motility patients treated with RefluxStop device Open
View article: Toupet fundoplication to prevent progression of scleroderma-associated interstitial lung damage: a study protocol
Toupet fundoplication to prevent progression of scleroderma-associated interstitial lung damage: a study protocol Open
View article: The effect of goal-directed crystalloid versus colloid administration on postoperative spirometry parameters: a substudy of a randomized controlled clinical trial
The effect of goal-directed crystalloid versus colloid administration on postoperative spirometry parameters: a substudy of a randomized controlled clinical trial Open
View article: The Milan score: A novel manometric tool for a more efficient diagnosis of gastro‐esophageal reflux disease
The Milan score: A novel manometric tool for a more efficient diagnosis of gastro‐esophageal reflux disease Open
Objective A definitive diagnosis of gastroesophageal reflux disease (GERD) depends on endoscopic and/or pH‐study criteria. However, high resolution manometry (HRM) can identify factors predicting GERD, such as ineffective esophageal motili…
View article: Safety and short-term efficacy of GERD patients with ineffective esophageal motility treated with RefluxStop™ device implantation – a multicentric observational study
Safety and short-term efficacy of GERD patients with ineffective esophageal motility treated with RefluxStop™ device implantation – a multicentric observational study Open
Background Gastroesophageal reflux disease (GERD) presents a general health problem with a variety of symptoms and an impairment of life quality. Conservative therapies do not offer sufficient symptom relief in up to 30% of patients. Espec…
View article: Systemic inflammatory biomarkers as prognostic tools in patients with gastroesophageal adenocarcinoma
Systemic inflammatory biomarkers as prognostic tools in patients with gastroesophageal adenocarcinoma Open
View article: Platelets as a prognostic factor for patients with adenocarcinoma of the gastroesophageal junction
Platelets as a prognostic factor for patients with adenocarcinoma of the gastroesophageal junction Open
Objective The aim of this study was to investigate the prognostic role of plasma platelet count (PLT), mean platelet volume (MPV), and the combined COP-MPV score in patients with resectable adenocarcinomas of the gastroesophageal junction.…
View article: Standardization of rectal cancer surgery and bowel preparation in Austria
Standardization of rectal cancer surgery and bowel preparation in Austria Open
View article: Preoperative BChE serves as a prognostic marker in patients with resectable AEG after neoadjuvant chemotherapy
Preoperative BChE serves as a prognostic marker in patients with resectable AEG after neoadjuvant chemotherapy Open
Background Diminished systemic serum butyrylcholinesterase (BChE), a biomarker for chronic inflammation, cachexia, and advanced tumor stage, has shown to play a prognostic role in various malignancies. The aim of this study was to investig…
View article: Is magnetic sphincter augmentation indicated in patients with laryngopharyngeal reflux?
Is magnetic sphincter augmentation indicated in patients with laryngopharyngeal reflux? Open
Up to 30% of patients with gastroesophageal reflux disease (GERD) suffer from laryngopharyngeal reflux (LPR) with symptoms, as chronic cough, laryngitis, or asthma. Besides life-style modifications and medical acid suppression, laparoscopi…
View article: Platelets as a prognostic factor for patients with adenocarcinoma of the gastroesophageal junction
Platelets as a prognostic factor for patients with adenocarcinoma of the gastroesophageal junction Open
Objective: Aim of this study was to investigate the prognostic role of plasma platelet count (PLT), mean platelet volume (MPV) and the combined COP-MPV score in patients with resectable adenocarcinomas of the gastroesophageal junction. Bac…
View article: Supplementary Tables 1-4 from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1
Supplementary Tables 1-4 from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1 Open
PDF file - 93K
View article: Supplemental Tables from MicroRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: Differences in Glandular Non-native Epithelium
Supplemental Tables from MicroRNA Profiles of Barrett's Esophagus and Esophageal Adenocarcinoma: Differences in Glandular Non-native Epithelium Open
Supplemental Table 1: Patient clinical and demographic characteristics. Supplemental Table 2: miRNAs differentially detected among esophageal adenocarcinoma and Barrett's esophagus. Supplemental Table 3: miRNAs differentially expressed amo…
View article: Supplementary Tables 1-4 from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1
Supplementary Tables 1-4 from MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1 Open
PDF file - 93K
View article: Data from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing
Data from Novel Clinically Relevant Genes in Gastrointestinal Stromal Tumors Identified by Exome Sequencing Open
Purpose: Chromosomal gains and losses resulting in altered gene dosage are known to be recurrent in gastrointestinal stromal tumors (GIST). The aim of our study was the identification of clinical relevant genes in these candidate re…