Sebastian Fürthauer
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View article: Centrosome Softening As A Mechanical Adaptation For Mitosis
Centrosome Softening As A Mechanical Adaptation For Mitosis Open
Centrosomes are microtubule-organizing centers important for mitotic spindle assembly and chromosome segregation. During mitosis, centrosomes are exposed to mechanical forces via the microtubules they nucleate, yet the material properties …
View article: Arrested coarsening, oscillations, and memory from a conserved phase separating nucleator in a self-straining cytoskeletal network
Arrested coarsening, oscillations, and memory from a conserved phase separating nucleator in a self-straining cytoskeletal network Open
How do phase separated cellular structures set their size? To elucidate this, we study the dynamics and steady states of a phase separating nucleator that is advected by the self-straining cytoskeletal network which it nucleates. We find (…
View article: Three types of actomyosin rings within a common cytoplasm exhibit distinct modes of contractility
Three types of actomyosin rings within a common cytoplasm exhibit distinct modes of contractility Open
Summary Actomyosin rings are specializations of the non-muscle actomyosin cytoskeleton that drive cell shape changes during division, wound healing, and other events. Contractile rings throughout phylogeny and in a range of cellular contex…
View article: Correction: Microtubule reorganization during female meiosis in C. elegans
Correction: Microtubule reorganization during female meiosis in C. elegans Open
View article: Spontaneous phase coordination and fluid pumping in model ciliary carpets
Spontaneous phase coordination and fluid pumping in model ciliary carpets Open
Ciliated tissues, such as in the mammalian lungs, brains, and reproductive tracts, are specialized to pump fluid. They generate flows by the collective activity of hundreds of thousands of individual cilia that beat in a striking metachron…
View article: Self-organized flows in phase-synchronizing active fluids
Self-organized flows in phase-synchronizing active fluids Open
Many active biological particles, such as swimming microorganisms or motor-proteins, do work on their environment by going though a periodic sequence of shapes. Interactions between particles can lead to the phase-synchronization of their …
View article: Active mechanics of sea star oocytes
Active mechanics of sea star oocytes Open
Actomyosin is a canonical example of an active material, driven out of equilibrium in part through the injection of energy by myosin motors. This influx of energy allows actomyosin networks to generate cellular-scale contractility, which u…
View article: How Cross-Link Numbers Shape the Large-Scale Physics of Cytoskeletal Materials
How Cross-Link Numbers Shape the Large-Scale Physics of Cytoskeletal Materials Open
Cytoskeletal networks are the main actuators of cellular mechanics, and a foundational example for active matter physics. In cytoskeletal networks, motion is generated on small scales by filaments that push and pull on each other via molec…
View article: A multiscale biophysical model gives quantized metachronal waves in a lattice of cilia
A multiscale biophysical model gives quantized metachronal waves in a lattice of cilia Open
Motile cilia are slender, hair-like cellular appendages that spontaneously oscillate under the action of internal molecular motors and are typically found in dense arrays. These active filaments coordinate their beating to generate metachr…
View article: How crosslink numbers shape the large-scale physics of cytoskeletal materials
How crosslink numbers shape the large-scale physics of cytoskeletal materials Open
Cytoskeletal networks are the main actuators of cellular mechanics, and a foundational example for active matter physics. In cytoskeletal networks, motion is generated on small scales by filaments that push and pull on each other via molec…
View article: Microtubule reorganization during female meiosis in C. elegans
Microtubule reorganization during female meiosis in C. elegans Open
Most female meiotic spindles undergo striking morphological changes while transitioning from metaphase to anaphase. The ultra-structure of meiotic spindles, and how changes to this structure correlate with such dramatic spindle rearrangeme…
View article: Decision letter: Learning developmental mode dynamics from single-cell trajectories
Decision letter: Learning developmental mode dynamics from single-cell trajectories Open
View article: Author response: Microtubule reorganization during female meiosis in C. elegans
Author response: Microtubule reorganization during female meiosis in C. elegans Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Most female meiotic spindles undergo strik…
View article: A hydraulic instability drives the cell death decision in the nematode germline
A hydraulic instability drives the cell death decision in the nematode germline Open
View article: A design framework for actively crosslinked filament networks
A design framework for actively crosslinked filament networks Open
Living matter moves, deforms, and organizes itself. In cells this is made possible by networks of polymer filaments and crosslinking molecules that connect filaments to each other and that act as motors to do mechanical work on the network…
View article: Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm
Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm Open
How bulk cytoplasm generates forces to separate post-anaphase microtubule (MT) asters in Xenopus laevis and other large eggs remains unclear. Previous models proposed that dynein-based, inward organelle transport generates length-dependent…
View article: Author response: Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm
Author response: Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm Open
View article: Co-movement of astral microtubules, organelles and F-actin suggests aster positioning by surface forces in frog eggs
Co-movement of astral microtubules, organelles and F-actin suggests aster positioning by surface forces in frog eggs Open
How bulk cytoplasm generates forces to separate post-anaphase microtubule (MT) asters in Xenopus laevis and other large eggs remains unclear. Previous models proposed dynein-based organelle transport generates length-dependent forces on as…
View article: Microtubule re-organization during female meiosis in<i>C. elegans</i>
Microtubule re-organization during female meiosis in<i>C. elegans</i> Open
The female meiotic spindles of most animals are acentrosomal and undergo striking morphological changes while transitioning from metaphase to anaphase. The ultra-structure of acentrosomal spindles, and how changes to this structure correla…
View article: Self-straining of actively crosslinked microtubule networks
Self-straining of actively crosslinked microtubule networks Open
View article: Actively crosslinked microtubule networks: mechanics, dynamics and filament sliding
Actively crosslinked microtubule networks: mechanics, dynamics and filament sliding Open
Cytoskeletal networks are foundational examples of active matter and central to self-organized structures in the cell. In vivo, these networks are active and heavily crosslinked. Relating their large-scale dynamics to properties of their c…
View article: Morphogenetic degeneracies in the actomyosin cortex.
Morphogenetic degeneracies in the actomyosin cortex. Open
One of the great challenges in biology is to understand the mechanisms by which morphogenetic processes arise from molecular activities. We investigated this problem in the context of actomyosin-based cortical flow in C. elegans zygotes, w…
View article: Author response: Morphogenetic degeneracies in the actomyosin cortex
Author response: Morphogenetic degeneracies in the actomyosin cortex Open
View article: C. Elegans Chromosomes Connect to Centrosomes by Anchoring into the Spindle Network
C. Elegans Chromosomes Connect to Centrosomes by Anchoring into the Spindle Network Open
View article: Connecting macroscopic dynamics with microscopic properties in active microtubule network contraction
Connecting macroscopic dynamics with microscopic properties in active microtubule network contraction Open
The cellular cytoskeleton is an active material, driven out of equilibrium by\nmolecular motor proteins. It is not understood how the collective behaviors of\ncytoskeletal networks emerge from the properties of the network's constituent\nm…
View article: C. elegans chromosomes connect to centrosomes by anchoring into the spindle network
C. elegans chromosomes connect to centrosomes by anchoring into the spindle network Open
The mitotic spindle ensures the faithful segregation of chromosomes. Here we combine the first large-scale serial electron tomography of whole mitotic spindles in early C. elegans embryos with live-cell imaging to reconstruct all microtubu…
View article: <i>C. elegans</i>chromosomes connect to centrosomes by anchoring into the spindle network
<i>C. elegans</i>chromosomes connect to centrosomes by anchoring into the spindle network Open
The mitotic spindle ensures the faithful segregation of chromosomes. To discover the nature of the crucial centrosome-to-chromosome connection during mitosis, we combined the first large-scale serial electron tomography of whole mitotic sp…
View article: Active contraction of microtubule networks
Active contraction of microtubule networks Open
Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the larg…
View article: Author response: Active contraction of microtubule networks
Author response: Active contraction of microtubule networks Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods Appendix References Decision letter Author response Article and author information Metrics Abstract Many cellular processes…