Sebastian Griewing
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View article: Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs
Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs Open
Activating PIK3CA mutations, present in up to 40% of hormone receptor-positive (HR + ), human epidermal growth factor receptor 2-negative (Her2 − ) breast cancer (BC) patients, can be effectively targeted with the alpha isoform-specific PI…
View article: ChatGPT, Google, or PINK? Who Provides the Most Reliable Information on Side Effects of Systemic Therapy for Early Breast Cancer?
ChatGPT, Google, or PINK? Who Provides the Most Reliable Information on Side Effects of Systemic Therapy for Early Breast Cancer? Open
Introduction: The survival in early breast cancer (BC) has been significantly improved thanks to numerous new drugs. Nevertheless, the information about the need for systemic therapy, especially chemotherapy, represents an additional stres…
View article: Current Developments from Silicon Valley – How Artificial Intelligence is Changing Gynecology and Obstetrics
Current Developments from Silicon Valley – How Artificial Intelligence is Changing Gynecology and Obstetrics Open
Artificial intelligence (AI) has become an omnipresent topic in the media. Lively discussions are being held on how AI could revolutionize the global healthcare landscape. The development of innovative AI models, including in the medical s…
View article: Proof-of-concept study of a small language model chatbot for breast cancer decision support – a transparent, source-controlled, explainable and data-secure approach
Proof-of-concept study of a small language model chatbot for breast cancer decision support – a transparent, source-controlled, explainable and data-secure approach Open
Purpose Large language models (LLM) show potential for decision support in breast cancer care. Their use in clinical care is currently prohibited by lack of control over sources used for decision-making, explainability of the decision-maki…
View article: Correction: Vignette-based comparative analysis of ChatGPT and specialist treatment decisions for rheumatic patients: results of the Rheum2Guide study
Correction: Vignette-based comparative analysis of ChatGPT and specialist treatment decisions for rheumatic patients: results of the Rheum2Guide study Open
View article: Vignette-based comparative analysis of ChatGPT and specialist treatment decisions for rheumatic patients: results of the Rheum2Guide study
Vignette-based comparative analysis of ChatGPT and specialist treatment decisions for rheumatic patients: results of the Rheum2Guide study Open
View article: Evolution of publicly available large language models for complex decision-making in breast cancer care
Evolution of publicly available large language models for complex decision-making in breast cancer care Open
Purpose This study investigated the concordance of five different publicly available Large Language Models (LLM) with the recommendations of a multidisciplinary tumor board regarding treatment recommendations for complex breast cancer pati…
View article: Awareness and intention-to-use of digital health applications, artificial intelligence and blockchain technology in breast cancer care
Awareness and intention-to-use of digital health applications, artificial intelligence and blockchain technology in breast cancer care Open
Emerging digital technologies promise to improve breast cancer care, however lack of awareness among clinicians often prevents timely adoption. This study aims to investigate current awareness and intention-to-use of three technologies amo…
View article: NGS-Guided Precision Oncology in Breast Cancer and Gynecological Tumors—A Retrospective Molecular Tumor Board Analysis
NGS-Guided Precision Oncology in Breast Cancer and Gynecological Tumors—A Retrospective Molecular Tumor Board Analysis Open
Background: Precision oncology treatments are being applied more commonly in breast and gynecological oncology through the implementation of Molecular Tumor Boards (MTBs), but real-world clinical outcome data remain limited. Methods: A ret…
View article: Discussion of hemodynamic optimization strategies and the canonical understanding of hemodynamics during biventricular mechanical support in cardiogenic shock: does the flow balance make the difference?
Discussion of hemodynamic optimization strategies and the canonical understanding of hemodynamics during biventricular mechanical support in cardiogenic shock: does the flow balance make the difference? Open
Background Mechanical circulatory support (MCS) devices may stabilize patients with severe cardiogenic shock (CS) following myocardial infarction (MI). However, the canonical understanding of hemodynamics related to the determination of th…
View article: Is there an association between endometriosis and subsequent breast cancer? A retrospective cohort study from Germany
Is there an association between endometriosis and subsequent breast cancer? A retrospective cohort study from Germany Open
Purpose Given the relatively high incidence of both endometriosis and breast cancer, investigating the potential connection between these gynecological diseases is of substantial clinical significance. However, there is no clear consensus …
View article: Challenging ChatGPT 3.5 in Senology—An Assessment of Concordance with Breast Cancer Tumor Board Decision Making
Challenging ChatGPT 3.5 in Senology—An Assessment of Concordance with Breast Cancer Tumor Board Decision Making Open
With the recent diffusion of access to publicly available large language models (LLMs), common interest in generative artificial-intelligence-based applications for medical purposes has skyrocketed. The increased use of these models by tec…
View article: Status quo and future directions of digitalization in gynecology and obstetrics in Germany: a survey of the commission Digital Medicine of the German Society for Gynecology and Obstetrics
Status quo and future directions of digitalization in gynecology and obstetrics in Germany: a survey of the commission Digital Medicine of the German Society for Gynecology and Obstetrics Open
View article: Current landscape of hospital information systems in gynecology and obstetrics in Germany: a survey of the commission Digital Medicine of the German Society for Gynecology and Obstetrics
Current landscape of hospital information systems in gynecology and obstetrics in Germany: a survey of the commission Digital Medicine of the German Society for Gynecology and Obstetrics Open
View article: Therapy delay due to COVID-19 pandemic among European women with breast cancer: prevalence and associated factors
Therapy delay due to COVID-19 pandemic among European women with breast cancer: prevalence and associated factors Open
Purpose This study investigates the impact of the COVID-19 pandemic on breast cancer (BC) care, analyzing treatment delays and factors associated with them. Methods This retrospective cross-sectional study analyzed data from the Oncology D…
View article: Resilience of Gynecological and Obstetric Inpatient Care in Central Germany in Times of Repetitive Socioeconomic Shocks—An Epidemiological Study Assessing Standardized Health Services Indicators and Economic Status According to the aG-DRG Catalog
Resilience of Gynecological and Obstetric Inpatient Care in Central Germany in Times of Repetitive Socioeconomic Shocks—An Epidemiological Study Assessing Standardized Health Services Indicators and Economic Status According to the aG-DRG Catalog Open
Sequential socioeconomic shocks, including the COVID-19 pandemic, economic recession, or energy and refugee crises in the face of violent conflicts, have led to the failure of healthcare systems in Europe. Against this background, the aim …
View article: Association between gout and subsequent breast cancer: a retrospective cohort study including 67,598 primary care patients in Germany
Association between gout and subsequent breast cancer: a retrospective cohort study including 67,598 primary care patients in Germany Open
View article: Initiation of Antiresorptive Drug Treatment during Endocrine Therapy for Breast Cancer—A Retrospective Cohort Study of 161,492 Patients in Germany
Initiation of Antiresorptive Drug Treatment during Endocrine Therapy for Breast Cancer—A Retrospective Cohort Study of 161,492 Patients in Germany Open
Background: The aim of this retrospective cohort study was to measure the proportion of women with an initial prescription of an antiresorptive drug (bisphosphonates or denosumab) during five years of endocrine breast cancer therapy. Metho…
View article: Association between Parkinson’s Disease Medication and the Risk of Lower Urinary Tract Infection (LUTI): A Retrospective Cohort Study
Association between Parkinson’s Disease Medication and the Risk of Lower Urinary Tract Infection (LUTI): A Retrospective Cohort Study Open
Background: The occurrence of autonomic dysfunctions (e.g., urological dysfunctions) is a common phenomenon during the course of Parkinson’s disease (PD) and resulting complications such as lower urinary tract infections (LUTI) are one of …
View article: Impact of the COVID-19 Pandemic on Gyne-Oncological Treatment—A Retrospective Single-Center Analysis of a German University Hospital with 30,525 Patients
Impact of the COVID-19 Pandemic on Gyne-Oncological Treatment—A Retrospective Single-Center Analysis of a German University Hospital with 30,525 Patients Open
The study pursues the objective of drawing a comparison between the data of gyne-oncology, gynecology, and obstetrics patient collectives of a German university hospital regarding the progression of patient number and corresponding treatme…
View article: Renal Protection and Hemodynamic Improvement by Impella® Microaxial Pump in Patients with Cardiogenic Shock
Renal Protection and Hemodynamic Improvement by Impella® Microaxial Pump in Patients with Cardiogenic Shock Open
Acute kidney injury is one of the most frequent and prognostically relevant complications in cardiogenic shock. The purpose of this study was to evaluate the potential effect of the Impella® pump on hemodynamics and renal organ perfusion i…
View article: Use Case Evaluation and Digital Workflow of Breast Cancer Care by Artificial Intelligence and Blockchain Technology Application
Use Case Evaluation and Digital Workflow of Breast Cancer Care by Artificial Intelligence and Blockchain Technology Application Open
This study aims at evaluating the use case potential of breast cancer care for artificial intelligence and blockchain technology application based on the patient data analysis at Marburg University Hospital and, thereupon, developing a dig…
View article: Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Cervical Cancer Screening in Gynecological Practices in Germany
Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Cervical Cancer Screening in Gynecological Practices in Germany Open
Purpose: the aim of this cross-sectional study was to analyze the impact of the COVID-19 pandemic on Cervical Cancer Screening (CCS) in gynecological practices in Germany. Methods: The basis of the analysis was the Uniform Evaluation Stand…
View article: Chronological Development of Cardiovascular Disease in Times of COVID-19: A Retrospective Analysis of Hospitalized Diseases of the Circulatory System and COVID-19 Patients of a German University Hospital
Chronological Development of Cardiovascular Disease in Times of COVID-19: A Retrospective Analysis of Hospitalized Diseases of the Circulatory System and COVID-19 Patients of a German University Hospital Open
This study aims at examining the chronological development of hospitalized cardiovascular and COVID-19 patients and comparing the effects on related sub-disciplines and main diagnoses for pre-pandemic (2017–2019) and pandemic (2020–2021) y…
View article: Persistence with tamoxifen and aromatase inhibitors in Germany: a retrospective cohort study with 284,383 patients
Persistence with tamoxifen and aromatase inhibitors in Germany: a retrospective cohort study with 284,383 patients Open
View article: Positive association between body height and breast cancer prevalence: a retrospective study with 135,741 women in Germany
Positive association between body height and breast cancer prevalence: a retrospective study with 135,741 women in Germany Open
Purpose The aim of this study was to analyze the prevalence of breast cancer in relation to body height and to investigate associations between body height and breast cancer in Germany. Methods This retrospective cohort study included 135,…
View article: Chronological development of in-patient oncology in times of COVID-19: a retrospective analysis of hospitalized oncology and COVID-19 patients of a German University Hospital
Chronological development of in-patient oncology in times of COVID-19: a retrospective analysis of hospitalized oncology and COVID-19 patients of a German University Hospital Open
View article: Impact of the COVID-19 Pandemic on Delivery of Gynecology and Obstetrics Services at a Maximum Care University Hospital in Germany
Impact of the COVID-19 Pandemic on Delivery of Gynecology and Obstetrics Services at a Maximum Care University Hospital in Germany Open
Zusammenfassung Einleitung Die COVID-19-Pandemie bedeutet einschneidende Maßnahmen für das nationale Gesundheitssystem. Dies bot den Anlass, die klinischen und ökonomischen Leistungsindikatoren der gynäkologischen und geburtshilflichen Ver…