Sebastian Hardt
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View article: Distinct autoreactive CD19– plasma cell subsets accumulate in lupus-prone mice
Distinct autoreactive CD19– plasma cell subsets accumulate in lupus-prone mice Open
View article: International Classification of Diseases-10–Based Risk Stratification and Implant Selection for Knee Arthroplasty Among Patients Who Have Psychiatric and Neurologic Comorbidities: A Registry-Based Analysis of 549,234 Cases
International Classification of Diseases-10–Based Risk Stratification and Implant Selection for Knee Arthroplasty Among Patients Who Have Psychiatric and Neurologic Comorbidities: A Registry-Based Analysis of 549,234 Cases Open
Psychiatric and neurologic comorbidities are heterogeneous, independent predictors of failure after TKA/UKA; implant design modifies risk. An International Classification of Diseases, Tenth Revision, German Modification-based, code plus-na…
View article: Postoperative weight-bearing restrictions and rehabilitation after periacetabular osteotomy: a systematic review
Postoperative weight-bearing restrictions and rehabilitation after periacetabular osteotomy: a systematic review Open
Aims This systematic review aimed to synthesize current evidence on postoperative rehabilitation strategies, particularly weight-bearing restrictions after periacetabular osteotomy (PAO). Methods A systematic review was conducted following…
View article: Prior osteosynthesis—unlike osteotomy—raises revision risk after total knee arthroplasty, predominantly via periprosthetic infection
Prior osteosynthesis—unlike osteotomy—raises revision risk after total knee arthroplasty, predominantly via periprosthetic infection Open
Purpose Previous knee surgery is discussed as a risk factor for total knee arthroplasty (TKA), yet most reports do not distinguish between osteotomy and osteosynthesis. The German Operationen‐ und Prozedurenschlüssel (OPS)‐based classifica…
View article: Methylomes of human CD4 and CD8 memory T lymphocytes reveal tissue-specific epigenetic signatures for maintenance and recall function
Methylomes of human CD4 and CD8 memory T lymphocytes reveal tissue-specific epigenetic signatures for maintenance and recall function Open
View article: Cementless one-stage hip revision arthroplasty with an injectable antibiotic bone graft substitute
Cementless one-stage hip revision arthroplasty with an injectable antibiotic bone graft substitute Open
Aims The classic, widely accepted approach for one-stage hip revision arthroplasty in patients with periprosthetic joint infection (PJI) is the cemented exchange. This approach provides stable implant anchoring despite bone defects after r…
View article: Impact of prior osteotomy and osteosynthesis on long-term outcomes after total hip arthroplasty
Impact of prior osteotomy and osteosynthesis on long-term outcomes after total hip arthroplasty Open
Aims Patients with a history of osteotomy or osteosynthesis pose distinct challenges in total hip arthroplasty (THA) due to altered anatomy and biomechanics. Although THA is an established intervention for degenerative hip disease, limited…
View article: Neurologic and psychiatric disorders as risk factors following hip arthroplasty: results from the German arthroplasty registry
Neurologic and psychiatric disorders as risk factors following hip arthroplasty: results from the German arthroplasty registry Open
Purpose We investigated whether neurologic and psychiatric disorders (ICD-10 F00–F99, G00–G99) increase postoperative complications and mortality after hip arthroplasty and identified subgroups with distinct complication patterns, includin…
View article: ILOBONE: A phase I/IIa randomized controlled trial to assess the safety and feasibility of local iloprost therapy for enhancing proximal humerus fracture healing– a pilot study design
ILOBONE: A phase I/IIa randomized controlled trial to assess the safety and feasibility of local iloprost therapy for enhancing proximal humerus fracture healing– a pilot study design Open
View article: Assessment of quality and readability of information provided by ChatGPT in relation to developmental dysplasia of the hip and periacetabular osteotomy
Assessment of quality and readability of information provided by ChatGPT in relation to developmental dysplasia of the hip and periacetabular osteotomy Open
This study evaluates the quality and readability of responses given by ChatGPT 4 relating to common patient queries on Developmental Dysplasia of the Hip (DDH) and Periacetabular Osteotomy (PAO). Frequently asked questions on DDH and PAO w…
View article: ILOBONE: A phase I/IIa randomized controlled trial to assess the safety and feasibility of local iloprost therapy for enhancing proximal humerus fracture healing – a pilot study design
ILOBONE: A phase I/IIa randomized controlled trial to assess the safety and feasibility of local iloprost therapy for enhancing proximal humerus fracture healing – a pilot study design Open
Background Proximal humerus fractures (PHFs) are the third most common fractures in elderly patients. Over 70% of PHFs in patients aged over 60 are displaced fractures, often necessitating surgical treatment. However, osteosynthesis is ass…
View article: From mobility to intimacy: assessing the effects of periacetabular osteotomy on sexual function in patients with hip dysplasia
From mobility to intimacy: assessing the effects of periacetabular osteotomy on sexual function in patients with hip dysplasia Open
Aims Developmental dysplasia of the hip (DDH) often leads to early osteoarthritis, causing pain and functional limitations that may impair sexual function. This study investigates the impact of periacetabular osteotomy (PAO) on sexual func…
View article: Impact of femoral head size on the localization of proximal femur fractures: Retrospective analysis of 400 cases
Impact of femoral head size on the localization of proximal femur fractures: Retrospective analysis of 400 cases Open
Larger femoral heads are associated with lateral fractures, whereas pertrochanteric fractures occur in older patients. Subtrochanteric fractures correlate with smaller femoral heads and advanced osteoarthritis.
View article: FP1.7 Outcomes and Return-to-Sports Rates in Patients With Borderline Hip Dysplasia After Periacetabular Osteotomy: A Case Series With 5-Year Follow-up
FP1.7 Outcomes and Return-to-Sports Rates in Patients With Borderline Hip Dysplasia After Periacetabular Osteotomy: A Case Series With 5-Year Follow-up Open
Background: The optimal surgical approach in patients with borderline hip dysplasia (BHD) remains controversial. Both hip arthroscopy and periacetabular osteotomy (PAO) are commonly employed in this patient population. Those who participat…
View article: EP2.38 Recovery of muscular tissue and functional results of patients treated with a gluteus maximus flap transfer due to chronic abductor deficiency
EP2.38 Recovery of muscular tissue and functional results of patients treated with a gluteus maximus flap transfer due to chronic abductor deficiency Open
Background: To evaluate the function of the abductor mechanism after a gluteus maximus flap transfer due to a degeneration of the muscles after hip arthroplasty, we analyzed the post-operative functional outcome as well as radiographic eff…
View article: Assessing the TNM Classification for Periprosthetic Joint Infections of the Knee: Predictive Validity for Functional and Subjective Outcomes
Assessing the TNM Classification for Periprosthetic Joint Infections of the Knee: Predictive Validity for Functional and Subjective Outcomes Open
Background: Periprosthetic joint infection (PJI) following knee arthroplasty can significantly compromise patient mobility and quality of life. The newly proposed TNM classification system, adapted from oncology, categorizes PJI severity b…
View article: The cemented stem in hip arthroplasty – state of the art technique and recommendations
The cemented stem in hip arthroplasty – state of the art technique and recommendations Open
The indication for femoral stem cementation should be made on a patient-specific basis, taking physical activity, femoral geometry, and bone tissue quality into account. Age alone should not be the sole justification for cementation. The D…
View article: Management of Intraoperative Acetabular Fractures in Total Hip Arthroplasty: A Current Concept Review
Management of Intraoperative Acetabular Fractures in Total Hip Arthroplasty: A Current Concept Review Open
Intraoperative acetabular fractures (IAFs), a complication seldomly encountered in total hip arthroplasty, are typically a result of the impact of insertion of a cementless press-fit cup. Factors that contribute to the risk of these types …
View article: Comparative analysis of femoral bone loss: uncemented vs. cemented aseptic stem loosening in first-time revision surgery—a retrospective evaluation of 215 patients
Comparative analysis of femoral bone loss: uncemented vs. cemented aseptic stem loosening in first-time revision surgery—a retrospective evaluation of 215 patients Open
View article: Recovery of muscular tissue and functional results of patients treated with a gluteus maximus flap transfer due to chronic abductor deficiency after total hip arthroplasty
Recovery of muscular tissue and functional results of patients treated with a gluteus maximus flap transfer due to chronic abductor deficiency after total hip arthroplasty Open
Background To evaluate the function of the abductor mechanism after a gluteus maximus flap transfer due to a degeneration of the muscles after hip arthroplasty, we analyzed the post-operative functional outcome as well as radiographic effe…
View article: Impact of fixation method on femoral bone loss: a retrospective evaluation of stem loosening in first-time revision total hip arthroplasty among two hundred and fifty five patients
Impact of fixation method on femoral bone loss: a retrospective evaluation of stem loosening in first-time revision total hip arthroplasty among two hundred and fifty five patients Open
View article: Success Rate After 2-Stage Spacer-Free Total Hip Arthroplasty Exchange and Risk Factors for Reinfection: A Prospective Cohort Study of 187 Patients
Success Rate After 2-Stage Spacer-Free Total Hip Arthroplasty Exchange and Risk Factors for Reinfection: A Prospective Cohort Study of 187 Patients Open
Reinfection rates after 2-stage spacer-free THA revision for PJI still remain high but are comparable to those including cement spacers. Patients who have had prior failed 2-stage implant exchanges or are infected by high-grade or difficul…
View article: The Subjective Hip Value is a Valid, Reliable, and Responsive Instrument for Assessing Hip Function in Primary Total Hip Arthroplasty
The Subjective Hip Value is a Valid, Reliable, and Responsive Instrument for Assessing Hip Function in Primary Total Hip Arthroplasty Open
View article: Cartilage Destruction by Hemophilic Arthropathy Can Be Prevented by Inhibition of the Ferroptosis Pathway in Human Chondrocytes
Cartilage Destruction by Hemophilic Arthropathy Can Be Prevented by Inhibition of the Ferroptosis Pathway in Human Chondrocytes Open
(1) Background: Around 50% of hemophilia patients develop severe arthropathy, with even subclinical hemorrhage in childhood potentially leading to intra-articular iron deposition, synovia proliferation, neoangiogenesis, and eventual damage…
View article: Outcomes and Return-to-Sports Rates in Patients With Borderline Hip Dysplasia After Periacetabular Osteotomy: A Case Series With 5-Year Follow-up
Outcomes and Return-to-Sports Rates in Patients With Borderline Hip Dysplasia After Periacetabular Osteotomy: A Case Series With 5-Year Follow-up Open
Background: The optimal surgical approach in patients with borderline hip dysplasia (BHD) remains controversial. Both hip arthroscopy and periacetabular osteotomy (PAO) are commonly employed in this patient population. Those who participat…
View article: Periacetabular osteotomy for symptomatic hip dysplasia in middle aged patients: does age alone matter?
Periacetabular osteotomy for symptomatic hip dysplasia in middle aged patients: does age alone matter? Open
View article: Gram negative periprosthetic hip infection: nearly 25% same pathogen infection persistence at a mean of 2 years
Gram negative periprosthetic hip infection: nearly 25% same pathogen infection persistence at a mean of 2 years Open
View article: Psychological status affects postoperative quality of life, function, and pain after periacetabular osteotomy
Psychological status affects postoperative quality of life, function, and pain after periacetabular osteotomy Open
Aims Psychological status may be an important predictor of outcome after periacetabular osteotomy (PAO). The aim of this study was to investigate the influence of psychological distress on postoperative health-related quality of life, join…
View article: Periacetabular Osteotomy with a Modified Fixation Technique Using K-Wires Shows Clinical Results Comparable to Screw Fixation at Mid-Term Follow-Up
Periacetabular Osteotomy with a Modified Fixation Technique Using K-Wires Shows Clinical Results Comparable to Screw Fixation at Mid-Term Follow-Up Open
Background: The optimal fixation technique in periacetabular osteotomy (PAO) remains controversial. Modified fixation with Kirschner wires (K-wires) was described as a feasible and safe alternative. However, clinical follow-up of patients …
View article: Is Elective Total Hip Arthroplasty Safe in Nonagenarians?
Is Elective Total Hip Arthroplasty Safe in Nonagenarians? Open
Background: An increasing number of elderly patients are becoming candidates for elective total hip arthroplasty (THA). Conflicting results exist with regard to the safety of THA in nonagenarians. The aims of this study were to evaluate po…