Sebastian Hempel
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View article: Predicting resectability after neoadjuvant chemotherapy for patients with borderline resectable pancreatic cancer: a single center, retrospective trial
Predicting resectability after neoadjuvant chemotherapy for patients with borderline resectable pancreatic cancer: a single center, retrospective trial Open
Background/Objectives Pancreatic ductal adeno carcinoma (PDAC) in its borderline resectable (BR) stage often limits the possibility of complete resection, currently the only potential path to a cure. Neoadjuvant chemotherapy seeks to downs…
View article: Pancreatoduodenectomy versus total pancreatectomy and simultaneous intraportal islet autotransplantation for periampullary cancer at high-risk of postoperative pancreatic fistula (XANDTX-trial): Protocol of a randomized controlled pilot trial
Pancreatoduodenectomy versus total pancreatectomy and simultaneous intraportal islet autotransplantation for periampullary cancer at high-risk of postoperative pancreatic fistula (XANDTX-trial): Protocol of a randomized controlled pilot trial Open
Introduction Pancreatic surgery remains associated with significant morbidity. Pancreatoduodenectomy (PD) with high-risk stigmata for postoperative pancreatic fistula (POPF) may delay or hinder administration of adjuvant therapy. Total pan…
View article: Does perioperative hydrocortisone reduce morbidity after pancreatoduodenectomy? A propensity score matched analysis
Does perioperative hydrocortisone reduce morbidity after pancreatoduodenectomy? A propensity score matched analysis Open
The use of steroids in pancreatic surgery may reduce complications through the anti-inflammatory potential. We aimed to evaluate the impact of hydrocortisone (HC) on postoperative morbidity after pancreatoduodenectomy (PD). The data were r…
View article: Glucose metabolism after distal pancreatectomy - deterioration of beta cell function becomes noticeable at an early stage: a retrospective cohort study
Glucose metabolism after distal pancreatectomy - deterioration of beta cell function becomes noticeable at an early stage: a retrospective cohort study Open
Background Distal pancreatectomy (DP) can worsen pancreatic endocrine function. Effects on glucose metabolism and underlying mechanisms after DP remains a topic of significant interest and not yet fully understood. This study aimed to exam…
View article: AutoFRS: an externally validated, annotation-free approach to computational preoperative complication risk stratification in pancreatic surgery – an experimental study
AutoFRS: an externally validated, annotation-free approach to computational preoperative complication risk stratification in pancreatic surgery – an experimental study Open
Background: The risk of postoperative pancreatic fistula (POPF), one of the most dreaded complications after pancreatic surgery, can be predicted from preoperative imaging and tabular clinical routine data. However, existing studies suffer…
View article: The Value of Blood T Cell Frequencies for Risk Prediction of Postoperative Complications in Pancreatic Cancer Surgery
The Value of Blood T Cell Frequencies for Risk Prediction of Postoperative Complications in Pancreatic Cancer Surgery Open
Objective: To quantify and characterize preoperative blood T cells in patients with pancreatic ductal adenocarcinoma (PDAC), who underwent tumor resection, and to determine their relevance as biomarkers for postoperative pancreas-specific …
View article: αvβ6-integrin targeted PET/CT imaging in pancreatic cancer patients using 68Ga-Trivehexin
αvβ6-integrin targeted PET/CT imaging in pancreatic cancer patients using 68Ga-Trivehexin Open
Purpose 68 Ga-Trivehexin is a PET tracer targeting αvβ6-integrin, a transmembrane receptor that is frequently expressed by pancreatic cancer cells. This study aimed to determine the biokinetics, image contrast, and acquisition parameters f…
View article: Bacterial shift and resistance pattern in pancreatic head resections after selective decontamination of the digestive tract – a propensity score-matched analysis
Bacterial shift and resistance pattern in pancreatic head resections after selective decontamination of the digestive tract – a propensity score-matched analysis Open
SDD in pancreatic head resection reduces bacterial load in the biliary tract, but it is associated with a shift toward more gram-negative species and higher rates of severe postoperative complications. Our findings suggest that SDD may neg…
View article: Concomitant metastatic head-and-neck cancer and pancreatic cancer assessed by αvβ6-integrin PET/CT using 68Ga-Trivehexin: incidental detection of a brain metastasis
Concomitant metastatic head-and-neck cancer and pancreatic cancer assessed by αvβ6-integrin PET/CT using 68Ga-Trivehexin: incidental detection of a brain metastasis Open
View article: Preoperative anaemia in distal pancreatectomy: a propensity-score matched analysis
Preoperative anaemia in distal pancreatectomy: a propensity-score matched analysis Open
View article: Textbook outcome after pancreatoduodenectomy and distal pancreatectomy with postoperative hyperamylasemia—a propensity score matching analysis
Textbook outcome after pancreatoduodenectomy and distal pancreatectomy with postoperative hyperamylasemia—a propensity score matching analysis Open
As a part of the definition for PPAP, POH is a predictive indicator associated with postoperative complications after PD but not after DP.
View article: Preoperative IL-8 levels as prognostic indicators of overall survival: an extended follow-up in a prospective cohort with colorectal liver metastases
Preoperative IL-8 levels as prognostic indicators of overall survival: an extended follow-up in a prospective cohort with colorectal liver metastases Open
View article: Development and Validation of a Model for Postpancreatectomy Hemorrhage Risk
Development and Validation of a Model for Postpancreatectomy Hemorrhage Risk Open
Importance Postpancreatectomy hemorrhage (PPH) due to postoperative pancreatic fistula (POPF) is a life-threatening complication after pancreatoduodenectomy. However, there is no prediction tool for early identification of patients at high…
View article: RAB27B expression in pancreatic cancer is predictive of poor survival but good response to chemotherapy
RAB27B expression in pancreatic cancer is predictive of poor survival but good response to chemotherapy Open
BACKGROUND: Pancreatic cancer is the 4th leading cause of cancer-related death with poor survival even after curative resection. RAB27A and RAB27B are key players in the exosome pathway where they play important roles in exosome secretion.…
View article: Systematic Review and Meta-analysis of the Role of Total Pancreatectomy as an Alternative to Pancreatoduodenectomy in Patients at High Risk for Postoperative Pancreatic Fistula
Systematic Review and Meta-analysis of the Role of Total Pancreatectomy as an Alternative to Pancreatoduodenectomy in Patients at High Risk for Postoperative Pancreatic Fistula Open
Objective: Examine the potential benefit of total pancreatectomy (TP) as an alternative to pancreatoduodenectomy (PD) in patients at high risk for postoperative pancreatic fistula (POPF). Summary Background Data: TP is mentioned as an alte…
View article: Selective Decontamination of the Digestive Tract in Pancreatic Head Resections—A Propensity Score-Matched Analysis
Selective Decontamination of the Digestive Tract in Pancreatic Head Resections—A Propensity Score-Matched Analysis Open
(1) Background: The postoperative morbidity rate after pancreatic head resection remains high, partly due to infectious complications. The primary aim of this study was to analyze the influence of selective decontamination of the digestive…
View article: Quality of life and metabolic outcomes after total pancreatectomy and simultaneous islet autotransplantation
Quality of life and metabolic outcomes after total pancreatectomy and simultaneous islet autotransplantation Open
Background Pancreas surgery remains technically challenging and is associated with considerable morbidity and mortality. Identification of predictive risk factors for complications have led to a stratified surgical approach and postoperati…
View article: Reply to: Letter to the Editor: More is More? Total Pancreatectomy for Periampullary Cancer as an Alternative in Patients with High-Risk Pancreatic Anastomosis: A Propensity Score-Matched Analysis, by Marchegiani, Giovanni et al.
Reply to: Letter to the Editor: More is More? Total Pancreatectomy for Periampullary Cancer as an Alternative in Patients with High-Risk Pancreatic Anastomosis: A Propensity Score-Matched Analysis, by Marchegiani, Giovanni et al. Open
View article: The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis
The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis Open
Background: Chronic pancreatitis (CP) often leads to recurrent pain as well as exocrine and/or endocrine pancreatic insufficiency. This study aimed to investigate the effect of pancreatic head resections on glucose metabolism in patients w…
View article: Short-term preoperative drainage is associated with improved postoperative outcomes compared to that of long-term biliary drainage in pancreatic surgery
Short-term preoperative drainage is associated with improved postoperative outcomes compared to that of long-term biliary drainage in pancreatic surgery Open
View article: Influence of the First Wave of the COVID-19 Pandemic on Cancer Care in a German Comprehensive Cancer Center
Influence of the First Wave of the COVID-19 Pandemic on Cancer Care in a German Comprehensive Cancer Center Open
Introduction: During the first wave of the COVID-19 pandemic in 2020, the German government implemented legal restrictions to avoid the overloading of intensive care units by patients with COVID-19. The influence of these effects on diagno…
View article: More is More? Total Pancreatectomy for Periampullary Cancer as an Alternative in Patients with High-Risk Pancreatic Anastomosis: A Propensity Score-Matched Analysis
More is More? Total Pancreatectomy for Periampullary Cancer as an Alternative in Patients with High-Risk Pancreatic Anastomosis: A Propensity Score-Matched Analysis Open
View article: Wound complications after primary and repeated midline, transverse and modified Makuuchi incision
Wound complications after primary and repeated midline, transverse and modified Makuuchi incision Open
There are 3 main types of incisions in major open, elective abdominal surgery: the midline incision (MI), the transverse incision (TI) and the modified Makuuchi incision (MMI). This study aimed to compare these approaches regarding wound c…
View article: Disease duration before surgical resection for chronic pancreatitis impacts long-term outcome
Disease duration before surgical resection for chronic pancreatitis impacts long-term outcome Open
Many patients with chronic pancreatitis (CP) undergo a step-up approach with interventional procedures as first-line treatment and resection reserved for later stages. The aim of this study was to identify predictive factors for a signific…
View article: Prognostic impact of para-aortic lymph node metastases in non-pancreatic periampullary cancer
Prognostic impact of para-aortic lymph node metastases in non-pancreatic periampullary cancer Open
View article: Drain Amylase or Lipase for the Detection of POPF—Adding Evidence to an Ongoing Discussion
Drain Amylase or Lipase for the Detection of POPF—Adding Evidence to an Ongoing Discussion Open
Objectives: A postoperative pancreatic fistula (POPF) is defined as a threefold increase in the amylase concentration in abdominal drains on or after the third postoperative day (POD). However, additional lipase fluid analysis is widely us…
View article: MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling
MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling Open
View article: <i>miR</i>-132 controls pancreatic beta cell proliferation and survival in mouse model through the <i>Pten/Akt/Foxo3</i> signaling
<i>miR</i>-132 controls pancreatic beta cell proliferation and survival in mouse model through the <i>Pten/Akt/Foxo3</i> signaling Open
Aim and hypothesis microRNAs (miRNAs) play an integral role in maintaining beta cell function and identity. Deciphering their targets and precise role, however, remains a challenge. In this study we aimed to identify miRNAs and their downs…
View article: Para-aortic lymph node metastases in pancreatic cancer should not be considered a watershed for curative resection
Para-aortic lymph node metastases in pancreatic cancer should not be considered a watershed for curative resection Open
View article: Performance of Lightweight Concrete based on Granulated Foamglass
Performance of Lightweight Concrete based on Granulated Foamglass Open
The paper presents an investigation of lightweight concretes properties, based on granulated foamglass (GFG-LWC) aggregates. The application of granulated foamglass (GFG) in concrete might significantly reduce the volume of waste glass and…