Sebastian Horstmann
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View article: Indoor residual spraying of experimental huts in Cameroon highlights the potential of Fludora® Fusion to control wild pyrethroid-resistant malaria vectors
Indoor residual spraying of experimental huts in Cameroon highlights the potential of Fludora® Fusion to control wild pyrethroid-resistant malaria vectors Open
Elevated resistance to pyrethroids has led to the introduction of novel insecticides including neonicotinoids. However, the efficacy of these new control products could be impacted by cross-resistance mechanisms from metabolic resistance t…
View article: Deltamethrin and Transfluthrin select for distinct transcriptomic responses in the malaria vector Anopheles gambiae.
Deltamethrin and Transfluthrin select for distinct transcriptomic responses in the malaria vector Anopheles gambiae. Open
Background The widespread use of pyrethroid insecticides in Africa has led to the development of strong resistance in Anopheles mosquitoes. Introducing new active ingredients can contribute to overcome this phenomenon and ensure the effect…
View article: Semi-field evaluation of the space spray efficacy of Fludora Co-Max EW against wild insecticide-resistant Aedes aegypti and Culex quinquefasciatus mosquito populations from Abidjan, Côte d’Ivoire
Semi-field evaluation of the space spray efficacy of Fludora Co-Max EW against wild insecticide-resistant Aedes aegypti and Culex quinquefasciatus mosquito populations from Abidjan, Côte d’Ivoire Open
Background Space spraying of insecticides is still an important means of controlling Aedes and Culex mosquitoes and arboviral diseases. This study evaluated the space spray efficacy of Fludora Co-Max EW, (water-based insecticide space spra…
View article: Semi-field evaluation of the space spray efficacy of Fludora Co-Max EW against wild insecticide-resistant Aedes aegypti and Culex quinquefasciatus mosquito populations from Abidjan, Côte d’Ivoire
Semi-field evaluation of the space spray efficacy of Fludora Co-Max EW against wild insecticide-resistant Aedes aegypti and Culex quinquefasciatus mosquito populations from Abidjan, Côte d’Ivoire Open
Background : Space spraying of insecticides is still an important mean of controlling Aedes and Culex mosquitoes and arboviral diseases. This study evaluated the space spray efficacy of Fludora Co-Max EW (a combination of flupyradifurone a…
View article: Semi-field evaluation of the space spray efficacy of Fludora Co-Max EW against wild insecticide-resistant <i>Aedes aegypti</i> and <i>Culex quinquefasciatus</i> mosquito populations from Abidjan, Côte d’Ivoire
Semi-field evaluation of the space spray efficacy of Fludora Co-Max EW against wild insecticide-resistant <i>Aedes aegypti</i> and <i>Culex quinquefasciatus</i> mosquito populations from Abidjan, Côte d’Ivoire Open
Background Space spraying of insecticides is still an important mean of controlling Aedes and Culex mosquitoes and arboviral diseases. This study evaluated the space spray efficacy of Fludora Co-Max EW (a combination of flupyradifurone and…
View article: Residual efficacy of Fludora Fusion against Anopheles arabiensis in simple huts in Ethiopia
Residual efficacy of Fludora Fusion against Anopheles arabiensis in simple huts in Ethiopia Open
Emergence and spread of malaria vectors resistant to the available insecticides required a new and efficacious insecticide. Residual efficacy of Fludora ® Fusion was evaluated against insecticide susceptible Anopheles arabiensis in ten cir…
View article: Assessing the anti-resistance potential of public health vaporizer formulations and insecticide mixtures with pyrethroids using transgenic Drosophila lines
Assessing the anti-resistance potential of public health vaporizer formulations and insecticide mixtures with pyrethroids using transgenic Drosophila lines Open
Background Insecticide resistance—and especially pyrethroid resistance—is a major challenge for vector control in public health. The use of insecticide mixtures utilizing alternative modes of action, as well as new formulations facilitatin…
View article: Neonicotinoid and pyrethroid combination: A tool to manage insecticide resistance in malaria vectors? Insights from experimental evolution
Neonicotinoid and pyrethroid combination: A tool to manage insecticide resistance in malaria vectors? Insights from experimental evolution Open
Background The introduction of neonicotinoids for managing insecticide resistance in mosquitoes is of high interest as they interact with a biochemical target not previously used in public health. In this concern, Bayer developed a combina…
View article: Residual Efficacy of Fludora® Fusion Against Anopheles Arabiensis in Simple Huts in Ethiopia
Residual Efficacy of Fludora® Fusion Against Anopheles Arabiensis in Simple Huts in Ethiopia Open
Emergence and spread of malaria vectors resistant to the available insecticides required a new and efficacious insecticide. Residual efficacy of Fludora ® Fusion was evaluated against insecticide susceptible Anopheles arabiensis in ten cir…
View article: Towards understanding transfluthrin efficacy in a pyrethroid-resistant strain of the malaria vector Anopheles funestus with special reference to cytochrome P450-mediated detoxification
Towards understanding transfluthrin efficacy in a pyrethroid-resistant strain of the malaria vector Anopheles funestus with special reference to cytochrome P450-mediated detoxification Open
Malaria vector control interventions rely heavily on the application of insecticides against anopheline mosquitoes, in particular the fast-acting pyrethroids that target insect voltage-gated sodium channels (VGSC). Frequent applications of…
View article: A low technology emanator treated with the volatile pyrethroid transfluthrin confers long term protection against outdoor biting vectors of lymphatic filariasis, arboviruses and malaria
A low technology emanator treated with the volatile pyrethroid transfluthrin confers long term protection against outdoor biting vectors of lymphatic filariasis, arboviruses and malaria Open
Transfluthrin-treated hessian emanators provide safe, affordable, long-term protection against several different pathogen-transmitting mosquito taxa that attack humans outdoors, where they are usually active and cannot be protected by bed …
View article: Discovery of Rigidified ?,?-Unsaturated Imines as New Resistance-breaking Insecticides for Malaria Vector Control
Discovery of Rigidified ?,?-Unsaturated Imines as New Resistance-breaking Insecticides for Malaria Vector Control Open
During our continuous search for new resistance-breaking insecticides applicable to malaria vector control, a new class of ?,?-unsaturated imines was identified by applying the principle of conformational rigidification as a powerful tool …
View article: Contact Bioassays with Phenoxybenzyl and Tetrafluorobenzyl Pyrethroids against Target-Site and Metabolic Resistant Mosquitoes
Contact Bioassays with Phenoxybenzyl and Tetrafluorobenzyl Pyrethroids against Target-Site and Metabolic Resistant Mosquitoes Open
The results of this study suggest that transfluthrin has the potential to control P450-mediated metabolically resistant mosquitoes because the structural formula of transfluthrin differs from that of the tested pyrethroids, which are used …