Sebastian Jaksch
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View article: PortGISANS: nested mirror optics for a portable GISANS adapter
PortGISANS: nested mirror optics for a portable GISANS adapter Open
View article: High-Density Inverted Micellar Intermediates Promote Membrane Fusion of Cationic Liposomes in Drug Delivery
High-Density Inverted Micellar Intermediates Promote Membrane Fusion of Cationic Liposomes in Drug Delivery Open
Liposomes have become increasingly popular as carriers for pharmaceutically relevant molecules such as nucleic acids, proteins, or anticancer drugs. The bottleneck in delivering such vehicles is their inefficient endosomal uptake by target…
View article: Gaussian model of fluctuating membrane and its scattering properties
Gaussian model of fluctuating membrane and its scattering properties Open
A mathematical model is developed to jointly analyze elastic and inelastic scattering data of fluctuating membranes within a single theoretical framework. The model builds on a nonhomogeneously clipped time-dependent Gaussian random field.…
View article: Review of: "Electron Tunneling in Ferritin and Its Potential Influence on Myelin and Cardiomyocytes"
Review of: "Electron Tunneling in Ferritin and Its Potential Influence on Myelin and Cardiomyocytes" Open
View article: A Gaussian model of fluctuating membrane and its scattering properties
A Gaussian model of fluctuating membrane and its scattering properties Open
A mathematical model is developed, to jointly analyze elastic and inelastic scattering data of fluctuating membranes within a single theoretical framework. The model builds on a non-homogeneously clipped time-dependent Gaussian random fiel…
View article: Timescales of Cell Membrane Fusion Mediated by SARS-CoV2 Spike Protein and its Receptor ACE2
Timescales of Cell Membrane Fusion Mediated by SARS-CoV2 Spike Protein and its Receptor ACE2 Open
In this manuscript we describe the investigation of the SARS-CoV2 membrane fusion timescale by means of small-angle neutron scattering (SANS) using hydrogen/deuterium contrast variation. After the successful production of virus-like vesicl…
View article: Polarisation Development at the European Spallation Source
Polarisation Development at the European Spallation Source Open
To meet the ever-increasing user demand, eleven of the fifteen European Spallation Source (ESS) instruments under construction aim to offer polarised neutrons for user experiments. They include an imaging instrument, a SANS instruments, tw…
View article: The GISANS instrument at the HBS
The GISANS instrument at the HBS Open
This manuscript describes a concept of a grazing incidence small-angle neutron scattering (GISANS) instrument for the high brilliance source (HBS). The HBS being a compact pulsed neutron source using a moderate energy proton accelerator wh…
View article: <i>MembraneDyn</i>: simulating the dynamics of supported membrane stacks on the nanosecond timescale
<i>MembraneDyn</i>: simulating the dynamics of supported membrane stacks on the nanosecond timescale Open
The static structure factor and the undulation dynamics of a solid-supported membrane stack have previously been calculated by Romanov and Ul'yanov [Romanov & Ul'yanov (2002). Phys. Rev. E , 66 , 061701]. Based on this prior work, the calc…
View article: Recent Advances in Small-Angle Neutron Scattering
Recent Advances in Small-Angle Neutron Scattering Open
Over the decades, small-angle neutron scattering has became a definitive method for structural investigation on the mesoscale between a few Angstrom up to a few 100 nm. This makes it an indispensable tool for non-destructive material inv…
View article: Ionic Liquid (EmimAc)-Water Mixture Confined in Nanoporous Glass Matrices Studied With High-Resolution Neutron Spectroscopy
Ionic Liquid (EmimAc)-Water Mixture Confined in Nanoporous Glass Matrices Studied With High-Resolution Neutron Spectroscopy Open
We report on the structure and diffusion behaviour of the various constituent molecules in ionic liquid (IL) mixtures under confinement in nanoporous glasses. X-Ray diffraction measurements indicate that the ions adopt a lamellar arrangeme…
View article: Recent Advances in Small-Angle Neutron Scattering
Recent Advances in Small-Angle Neutron Scattering Open
Small-angle scattering, and its neutron expression small-angle neutron scattering (SANS), has developed into an invaluable tool for the investigation of microscopic and mesoscopic structures in recent decades [...]
View article: Multiple scattering and resolution effects in small-angle neutron scattering experiments calculated and corrected by the software package <i>MuScatt</i>
Multiple scattering and resolution effects in small-angle neutron scattering experiments calculated and corrected by the software package <i>MuScatt</i> Open
This article deals with multiple scattering effects that are important for the method of small-angle neutron scattering (SANS). It considers three channels for the coherent elastic, the incoherent elastic and the incoherent inelastic scatt…
View article: Flexible Sample Environments for the Investigation of Soft Matter at the European Spallation Source: Part III—The Macroscopic Foam Cell
Flexible Sample Environments for the Investigation of Soft Matter at the European Spallation Source: Part III—The Macroscopic Foam Cell Open
The European Spallation Source (ESS), which is under construction in Lund (Sweden), will be the leading and most brilliant neutron source and aims at starting user operation at the end of 2023. Among others, two small angle neutron scatter…
View article: Influence of NaCl on the Structure and Dynamics of Phospholipid Layers
Influence of NaCl on the Structure and Dynamics of Phospholipid Layers Open
We present a structural and dynamical analysis of the influence of NaCl on multilayer stacks of phospholipids on a solid surface. To this end, multilayer stacks of phospholipids (L-α-phosphatidylcholine, abbreviated as SoyPC) are investiga…
View article: Flexible Sample Environment for the Investigation of Soft Matter at the European Spallation Source: Part II—The GISANS Setup
Flexible Sample Environment for the Investigation of Soft Matter at the European Spallation Source: Part II—The GISANS Setup Open
The FlexiProb project is a joint effort of three soft matter groups at the Universities of Bielefeld, Darmstadt, and Munich with scientific support from the European Spallation Source (ESS), the small-K advanced diffractometer (SKADI) beam…
View article: Flexible Sample Environments for the Investigation of Soft Matter at the European Spallation Source: Part I—The In Situ SANS/DLS Setup
Flexible Sample Environments for the Investigation of Soft Matter at the European Spallation Source: Part I—The In Situ SANS/DLS Setup Open
As part of the development of the new European Spallation Source (ESS) in Lund (Sweden), which will provide the most brilliant neutron beams worldwide, it is necessary to provide different sample environments with which the potential of th…
View article: Technical Specification of the Small-Angle Neutron Scattering Instrument SKADI at the European Spallation Source
Technical Specification of the Small-Angle Neutron Scattering Instrument SKADI at the European Spallation Source Open
Small-K Advanced DIffractometer (SKADI is a Small-Angle Neutron Scattering (SANS) instrument to be constructed at the European Spallation Source (ESS). SANS instruments allow investigations of the structure of materials in the size regime …
View article: Response of a Li-glass/multi-anode photomultiplier detector to collimated thermal-neutron beams
Response of a Li-glass/multi-anode photomultiplier detector to collimated thermal-neutron beams Open
View article: Flexible Sample Environments for the Investigation of Soft Matter at the European Spallation Source: Part I—The In Situ SANS/DLS Setup
Flexible Sample Environments for the Investigation of Soft Matter at the European Spallation Source: Part I—The In Situ SANS/DLS Setup Open
As part of the development of the new European Spallation Source (ESS) in Lund (Sweden), which will provide the most brilliant neutron beams worldwide, it is necessary to provide different sample environments with which the potential of th…
View article: Flexible Sample Environments for the Investigation of Soft Matter at the European Spallation Source: Part III—The Macroscopic Foam Cell
Flexible Sample Environments for the Investigation of Soft Matter at the European Spallation Source: Part III—The Macroscopic Foam Cell Open
The European Spallation Source (ESS), which is under construction in Lund (Sweden), will be the leading and most brilliant neutron source and aims at starting user operation at the end of 2023. Among others, two small angle neutron scatter…
View article: Drug-Induced Morphology Switch in Drug Delivery Systems Based on Poly(2-oxazoline)s
Drug-Induced Morphology Switch in Drug Delivery Systems Based on Poly(2-oxazoline)s Open
Defined aggregates of polymers such as polymeric micelles are of great importance in the development of pharmaceutical formulations. The amount of drug that can be formulated by a drug delivery system is an important issue, and most drug d…
View article: Response of a Li-glass/multi-anode photomultiplier detector to focused proton and deuteron beams
Response of a Li-glass/multi-anode photomultiplier detector to focused proton and deuteron beams Open
The response of a position-sensitive Li-glass based scintillation detector to\nfocused beams of 2.5 MeV protons and deuterons has been investigated. The beams\nwere scanned across the detector in 0.5 mm horizontal and vertical steps\nperpe…
View article: Probing the Complex Loading-Dependent Structural Changes in Ultrahigh Drug-Loaded Polymer Micelles by Small-Angle Neutron Scattering
Probing the Complex Loading-Dependent Structural Changes in Ultrahigh Drug-Loaded Polymer Micelles by Small-Angle Neutron Scattering Open
Drug-loaded polymer micelles or nanoparticles are being continuously explored in the fields of drug delivery and nanomedicine. Commonly, a simple core-shell structure is assumed, in which the core incorporates the drug and the corona provi…
View article: The instrument suite of the European Spallation Source
The instrument suite of the European Spallation Source Open
View article: Probing the Complex Loading Dependent Structural Changes in Ultra-High Drug Loaded Polymer Micelles by Small-Angle Neutron Scattering
Probing the Complex Loading Dependent Structural Changes in Ultra-High Drug Loaded Polymer Micelles by Small-Angle Neutron Scattering Open
Drug loaded polymer micelles or nanoparticles are being continuously explored in the fields of drug delivery and nanomedicine. Commonly, a simple core-shell structure is assumed, in which the core incorporates the drug and the corona provi…
View article: Probing the Complex Loading Dependent Structural Changes in Ultra-High Drug Loaded Polymer Micelles by Small-Angle Neutron Scattering
Probing the Complex Loading Dependent Structural Changes in Ultra-High Drug Loaded Polymer Micelles by Small-Angle Neutron Scattering Open
Drug loaded polymer micelles or nanoparticles are being continuously explored in the fields of drug delivery and nanomedicine. Commonly, a simple core-shell structure is assumed, in which the core incorporates the drug and the corona provi…
View article: Tunable viscosity modification with diluted particles: when particles decrease the viscosity of complex fluids
Tunable viscosity modification with diluted particles: when particles decrease the viscosity of complex fluids Open
While spherical particles are the most studied viscosity modifiers, they are well known only to increase viscosities, in particular at low concentrations of approx. 1%. Extended studies and theories on non-spherical particles in simple flu…
View article: Phospholipid membrane dynamics at the solid–liquid interface studied with grazing incidence neutron spin echo spectroscopy
Phospholipid membrane dynamics at the solid–liquid interface studied with grazing incidence neutron spin echo spectroscopy Open
Neutron spin echo spectroscopy has been used under grazing incidence conditions to study the dynamics of SoyPC phospholipid membranes at the solid-liquid interface. The use of advanced neutron optical components such as a neutron prism and…
View article: Influence of Environmental Conditions on the Fusion of Cationic Liposomes with Living Mammalian Cells
Influence of Environmental Conditions on the Fusion of Cationic Liposomes with Living Mammalian Cells Open
Lipid-based nanoparticles, also called vesicles or liposomes, can be used as carriers for drugs or many types of biological macromolecules, including DNA and proteins. Efficiency and speed of cargo delivery are especially high for carrier …