Sebastian Kehrloesser
YOU?
Author Swipe
View article: Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree
Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree Open
The transcription factor p63 shares a high sequence identity with the tumour suppressor p53 which manifests itself in high structural similarity and preference for DNA sequences. Mutations in the DNA binding domain (DBD) of p53 have been s…
View article: Cell-of-origin–specific proteomics of extracellular vesicles
Cell-of-origin–specific proteomics of extracellular vesicles Open
The ability to assign cellular origin to low-abundance secreted factors in extracellular vesicles (EVs) would greatly facilitate the analysis of paracrine-mediated signaling. Here, we report a method, named selective isolation of extracell…
View article: Analysing the attributes of Comprehensive Cancer Centres and Cancer Centres across Europe to identify key hallmarks
Analysing the attributes of Comprehensive Cancer Centres and Cancer Centres across Europe to identify key hallmarks Open
There is a persistent variation in cancer outcomes among and within European countries suggesting (among other causes) inequalities in access to or delivery of high‐quality cancer care. European policy (EU Cancer Mission and Europe’s Beati…
View article: Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain
Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain Open
View article: CHK2 sets the stage for CK1 in oocyte quality control
CHK2 sets the stage for CK1 in oocyte quality control Open
View article: Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome
Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome Open
The p63 gene encodes a master regulator of epidermal commitment, development, and differentiation. Heterozygous mutations in the C-terminal domain of the p63 gene can cause ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome…
View article: Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2
Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2 Open
View article: Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family
Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family Open
View article: Structural Evolution and Dynamics of the p53 Proteins
Structural Evolution and Dynamics of the p53 Proteins Open
The family of the p53 tumor suppressive transcription factors includes p73 and p63 in addition to p53 itself. Given the high degree of amino-acid-sequence homology and structural organization shared by the p53 family members, they display …
View article: Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level
Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level Open
Mammalian oocytes are arrested in the dictyate stage of meiotic prophase I for long periods of time, during which the high concentration of the p53 family member TAp63α sensitizes them to DNA damage-induced apoptosis. TAp63α is kept in an …
View article: Author response: Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level
Author response: Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mammalian oocytes are arreste…