Sebastian Klapa
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View article: 10 Fragen an Sebastian Klapa zur MANDARA-Studie
10 Fragen an Sebastian Klapa zur MANDARA-Studie Open
View article: Transition from psoriasis to psoriatic arthritis is characterized by distinct alterations in peripheral blood Tc17, Th17 and CD4+ TEM cells
Transition from psoriasis to psoriatic arthritis is characterized by distinct alterations in peripheral blood Tc17, Th17 and CD4+ TEM cells Open
Objective Cellular mechanisms driving transition from psoriasis to psoriatic arthritis have remained largely elusive. Thus, we investigated changes within the peripheral blood T cell compartment associated with the transition phase. Method…
View article: Advancing research on regulatory autoantibodies targeting GPCRs: Insights from the 5th international symposium
Advancing research on regulatory autoantibodies targeting GPCRs: Insights from the 5th international symposium Open
The 5th International Symposium on Regulatory Autoantibodies Targeting GPCR (RAB-GPCRs) advanced the understanding of the significant role played by autoantibodies targeting G-protein-coupled receptors (GPCRs) in various human diseases. On…
View article: POS0858 INCREASED RISK FOR CARDIAC AND VASCULAR MORBIDITY IN GIANT CELL ARTERITIS (GCA): LARGE-SCALE PROPENSITY-MATCHED GLOBAL RETROSPECTIVE COHORT STUDY
POS0858 INCREASED RISK FOR CARDIAC AND VASCULAR MORBIDITY IN GIANT CELL ARTERITIS (GCA): LARGE-SCALE PROPENSITY-MATCHED GLOBAL RETROSPECTIVE COHORT STUDY Open
View article: POS0082 EXPLORING THE GENETIC BASIS OF CLINICAL HETEROGENEITY IN GIANT CELL ARTERITIS
POS0082 EXPLORING THE GENETIC BASIS OF CLINICAL HETEROGENEITY IN GIANT CELL ARTERITIS Open
View article: POS0861 BEYOND IgG: EXPLORING THE ADDITIVE VALUE OF ANTI-MPO IgM IN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS (AAV)
POS0861 BEYOND IgG: EXPLORING THE ADDITIVE VALUE OF ANTI-MPO IgM IN ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS (AAV) Open
View article: First-line biological versus conventional synthetic disease-modifying antirheumatic drug therapy in adult-onset Still's disease: a multicentre, retrospective, propensity weighted cohort study
First-line biological versus conventional synthetic disease-modifying antirheumatic drug therapy in adult-onset Still's disease: a multicentre, retrospective, propensity weighted cohort study Open
None.
View article: Real-world outcomes of rituximab- and cyclophosphamide-based induction therapy regimens alone and in combination over 24 months in ANCA-associated vasculitis
Real-world outcomes of rituximab- and cyclophosphamide-based induction therapy regimens alone and in combination over 24 months in ANCA-associated vasculitis Open
RTX alone was similarly effective to RTX/CYC combination and CYC-AZA therapy in AAV patients, including those with severe renal involvement.
View article: Decreased concentrations of C5a complement receptor antibodies are associated with relapse in eosinophilic granulomatosis with polyangiitis (EGPA)
Decreased concentrations of C5a complement receptor antibodies are associated with relapse in eosinophilic granulomatosis with polyangiitis (EGPA) Open
View article: Avacopan with combined cyclophosphamide and rituximab for induction therapy in severe ANCA-associated vasculitis: retrospective observational study of 30 patients in two German referral centres
Avacopan with combined cyclophosphamide and rituximab for induction therapy in severe ANCA-associated vasculitis: retrospective observational study of 30 patients in two German referral centres Open
In this observational study, avacopan as GC-sparing agent appeared safe and efficacious in combination with RTX and CYC for remission induction in severe ANCA-associated vasculitis. In this subgroup, prospective studies are needed to deter…
View article: Increased serum soluble interleukin-2 receptor concentrations are linked to high-sensitivity troponin T and disease progression in systemic sclerosis
Increased serum soluble interleukin-2 receptor concentrations are linked to high-sensitivity troponin T and disease progression in systemic sclerosis Open
sIL-2R concentrations reflect disease severity, particularly cardiac damage, and early disease progression, and suggest a potential role for disease and therapy monitoring. Thus, sIL-2R should be further evaluated as a biomarker in SSc in …
View article: The Immersion-Induced Pulmonary Edema in Swimming and Diving
The Immersion-Induced Pulmonary Edema in Swimming and Diving Open
Staying in or underwater can lead to acute pulmonary complaints, which clinically present as an acute immersion-induced pulmonary edema (IPE), particular in strenuous swimming (SIPE) or diving (DIPE). The IPE presents as a cardiac pulmonar…
View article: Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study
Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study Open
Institute of Health Carlos III, Spanish Ministry of Science and Innovation, UK Medical Research Council, and National Institute for Health and Care Research.
View article: Myeloperoxidase-specific antineutrophil cytoplasmic antibody-associated vasculitis
Myeloperoxidase-specific antineutrophil cytoplasmic antibody-associated vasculitis Open
View article: First-Line Biological vs. Conventional Therapy in Adult-Onset Still's Disease a Multicentre, Retrospective, Propensity Weighted Analysis
First-Line Biological vs. Conventional Therapy in Adult-Onset Still's Disease a Multicentre, Retrospective, Propensity Weighted Analysis Open
View article: POS1161 RITUXIMAB VS. COMBINATION OF RITUXIMAB AND CYCLOPHOSPHAMIDE INDUCTION THERAPY FOR ANCA-ASSOCIATED VASCULITIS: A RETROSPECTIVE STUDY
POS1161 RITUXIMAB VS. COMBINATION OF RITUXIMAB AND CYCLOPHOSPHAMIDE INDUCTION THERAPY FOR ANCA-ASSOCIATED VASCULITIS: A RETROSPECTIVE STUDY Open
View article: OP0102 IDENTIFICATION OF NEW RISK LOCI AND PATHWAYS INVOLVED IN GCA PATHOGENESIS BY A GENOME-WIDE STUDY
OP0102 IDENTIFICATION OF NEW RISK LOCI AND PATHWAYS INVOLVED IN GCA PATHOGENESIS BY A GENOME-WIDE STUDY Open
View article: Analysis of Single- and Double-Stranded DNA Damage in Osteoblastic Cells after Hyperbaric Oxygen Exposure
Analysis of Single- and Double-Stranded DNA Damage in Osteoblastic Cells after Hyperbaric Oxygen Exposure Open
(1) Background: Hyperbaric oxygen (HBO) exposure induces oxidative stress that may lead to DNA damage, which has been observed in human peripheral blood lymphocytes or non-human cells. Here, we investigated the impact of hyperbaric conditi…
View article: Low Concentrations of C5a Complement Receptor Antibodies Are Linked to Disease Activity and Relapse in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis
Low Concentrations of C5a Complement Receptor Antibodies Are Linked to Disease Activity and Relapse in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis Open
Objective To examine concentrations of circulating antibodies targeting C3a and C5a complement receptors in antineutrophil cytoplasmic autoantibody (ANCA)–associated vasculitis (AAV) and analyze their association with disease activity. Met…
View article: Correction to: Diving ergospirometry with suspended weights: breathing- and fin-swimming style matter
Correction to: Diving ergospirometry with suspended weights: breathing- and fin-swimming style matter Open
View article: Diving ergospirometry with suspended weights: breathing- and fin-swimming style matter
Diving ergospirometry with suspended weights: breathing- and fin-swimming style matter Open
View article: A 56-Year-Old Woman with Chronic Hepatitis C Liver Disease and Meningitis due to Streptococcus equi subsp. Zooepidemicus
A 56-Year-Old Woman with Chronic Hepatitis C Liver Disease and Meningitis due to Streptococcus equi subsp. Zooepidemicus Open
Streptococcus equi subsp. zooepidemicus (S. equi subsp. zooepidemicus), which carries the Lancefield group C antigen, is an uncommon human pathogen. It is considered an opportunistic commensal of the equine upper respiratory tract and caus…
View article: Granulomatous Inflammation in ANCA-Associated Vasculitis
Granulomatous Inflammation in ANCA-Associated Vasculitis Open
ANCA-associated vasculitis (AAV) comprises granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). While systemic vasculitis is a hallmark of all AAV, GPA is charact…
View article: Expansion of CD161 expressing CD8+ single-positive and CD4+CD8+ double-positive PR3-specific T-cells in granulomatosis with polyangiitis
Expansion of CD161 expressing CD8+ single-positive and CD4+CD8+ double-positive PR3-specific T-cells in granulomatosis with polyangiitis Open
View article: The conundrum of using hyperoxia in COVID-19 treatment strategies: may intermittent therapeutic hyperoxia play a helpful role in the expression of the surface receptors ACE2 and Furin in lung tissue via triggering of HIF-1α?
The conundrum of using hyperoxia in COVID-19 treatment strategies: may intermittent therapeutic hyperoxia play a helpful role in the expression of the surface receptors ACE2 and Furin in lung tissue via triggering of HIF-1α? Open
View article: AB0496 AUTOANTIBODIES TARGETING COMPLEMENT RECEPTORS 3A AND 5A1 ARE DECREASED IN ANCA-ASSOCIATED VASCULITIS AND CORRELATE WITH HIGHER RELAPSE RATE.
AB0496 AUTOANTIBODIES TARGETING COMPLEMENT RECEPTORS 3A AND 5A1 ARE DECREASED IN ANCA-ASSOCIATED VASCULITIS AND CORRELATE WITH HIGHER RELAPSE RATE. Open
View article: Senior competitive ballroom dancers underestimate theirexertion in final rounds training
Senior competitive ballroom dancers underestimate theirexertion in final rounds training Open
Knowledge about individual strain in competitive ballroom dancing is limited, particular for senior couples. We evaluated the exertion during a simulated final round, covering all five tournament ballroom dances. Heartrate, blood-lactate, …
View article: SAT0021 ELEVATED NUMBERS OF C-TYPE LECTIN CD161 POSITIVE PR3-SPECIFIC T-CELLS IN GPA
SAT0021 ELEVATED NUMBERS OF C-TYPE LECTIN CD161 POSITIVE PR3-SPECIFIC T-CELLS IN GPA Open
View article: 197. INCREASED EXPRESSION OF THE COSTIMULATORY C-TYPE LECTIN (CD161) ON CIRCULATING PR3-SPECIFIC CD8+ and CD4+CD8+ T-CELLS IN GPA
197. INCREASED EXPRESSION OF THE COSTIMULATORY C-TYPE LECTIN (CD161) ON CIRCULATING PR3-SPECIFIC CD8+ and CD4+CD8+ T-CELLS IN GPA Open
View article: 207. ANTI-PROTEINASE 3 IMMUNOGLOBULIN VARIABLE REGION LIGHT CHAIN GENES AND INCREASED FREQUENCY OF FAB GLYCOSYLATION SITES IN INFLAMED TISSUE OF ANCA-ASSOCIATED VASCULITIS
207. ANTI-PROTEINASE 3 IMMUNOGLOBULIN VARIABLE REGION LIGHT CHAIN GENES AND INCREASED FREQUENCY OF FAB GLYCOSYLATION SITES IN INFLAMED TISSUE OF ANCA-ASSOCIATED VASCULITIS Open
patients with history of relapse showed higher Th17 response to MPO/ PR3 (p ¼ 0.047) compared to patients without history of relapse.In addition, remission patients with persistence of hematuria also presented higher responsiveness compare…