Explanipedia

Large language models for automatable real-world performance monitoring of diagnostic decision support systems: a comparison to manual doctor panel review in a prospective clinical study Open

Fabienne Cotte, Marcel Schmude, Philipp Bode, Oula Suliman, Filipa Dias Lourenço , et al. · 2025

Background Diagnostic decision support systems (DDSS) are increasingly deployed at scale, yet their diagnostic accuracy is insufficiently monitored once integrated into care. Traditional post-market surveillance relies on clinician review,…

Assessing Economic and Operational Feasibility of a Designed and Lab Demonstrated Robotic Platform for Omnichannel Logistics Open

Joyjit Bhowmick, Sebastian Koehler, G. Arndt, Georg Fischer, Manmit Padhy , et al. · 2024

THE ASSOCIATIONS OF SOCIOECONOMIC POSITION WITH STRUCTURAL BRAIN DAMAGE AND CONNECTIVITY AND COGNITION Open

Anouk F.J. Geraets, Miranda T. Schram, Sebastian Koehler, Jacobus F.A. Jansen, Martin P.J. van Boxtel , et al. · 2023

Socioeconomic inequalities in the risk for cognitive impairment have been reported, which might partly act through structural brain damage and connectivity. This study investigated the extent to which the association of early-life socioeco…

The Ontology of Biological Attributes (OBA)—computational traits for the life sciences Open

Ray Stefancsik, James P. Balhoff, Meghan A. Balk, Robyn L. Ball, Susan M. Bello , et al. · 2023

The Ontology of Biological Attributes (OBA) - Computational Traits for the Life Sciences Open

Ray Stefancsik, James P. Balhoff, Meghan A. Balk, Robyn L. Ball, Susan M. Bello , et al. · 2023

Existing phenotype ontologies were originally developed to represent phenotypes that manifest as a character state in relation to a wild-type or other reference. However, these do not include the phenotypic trait or attribute categories re…

A Simple Standard for Sharing Ontological Mappings (SSSOM) Open

Nicolas Matentzoglu, James P. Balhoff, Susan M. Bello, Chris Bizon, Matthew Brush , et al. · 2022

Despite progress in the development of standards for describing and exchanging scientific information, the lack of easy-to-use standards for mapping between different representations of the same or similar objects in different databases po…

Study design of FINGER‐NL: A multidomain lifestyle intervention in Dutch older adults to prevent cognitive decline Open

Marissa D. Zwan, Kay Deckers, Jurgen A.H.R. Claassen, Joukje M. Oosterman, Rianne A.A. de Heus , et al. · 2021

Background Previous multidomain lifestyle intervention trials to prevent cognitive decline in non‐demented elderly have found conflicting effects, with positive findings including the multidomain FINnish GERiatric intervention (FINGER) stu…

White matter network structure as a substrate of cognitive brain reserve in cerebral small‐vessel disease: The Maastricht Study Open

Nathan De Jong, Walter H. Backes, Jacobus F.A. Jansen, Martin P.J. van Boxtel, Miranda T. Schram , et al. · 2021

Method The Maastricht Study is a population‐based cohort study with extensive phenotyping, enriched for type‐2 diabetes. Cognitive test scores, structural connectivity data, and 3T MRI were available for n=4798 participants (mean age(±SD)=…

The association of depression with structural brain markers and cognitive impairment: The Maastricht study Open

Anouk F.J. Geraets, Miranda T. Schram, Jacobus F.A. Jansen, Annemarie Koster, Pieter C. Dagnelie , et al. · 2020

Background The risk of dementia is doubled in depression. However, the underlying etiology remains unclear. Clinical studies suggest that depression is related to brain atrophy and cerebral small vessel disease (cSVD), which are themselves…

Correlations of plasma kynurenines with CSF levels, and their relation to markers of Alzheimer’s disease pathology, diagnostic phases and cognitive performance Open

Lieke Bakker, Sebastian Koehler, Kyonghwan Choe, Daniël L.A. van den Hove, Günter Kenis , et al. · 2020

Background Finding novel biomarkers for Alzheimer’s disease (AD) for prediction, diagnosis or disease monitoring is a key research area. The kynurenine pathway(KP) consists of different metabolites of the essential amino acid tryptophan th…

The prevalence of young onset dementia: A systematic review and meta‐analysis Open

Stevie Hendriks, Kirsten Peetoom, Frans R.J. Verhey, Marjolein de Vugt, Sebastian Koehler · 2020

Background Onset of dementia before the age of 65 years is usually referred to as young onset dementia (YOD). Out of the total prevalence of dementia, it is estimated that 6‐9% are accounted for by YOD, but data to build robust estimates o…

Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index Open

Kay Deckers, Sebastian Koehler, Tiia Ngandu, Frans R.J. Verhey, Miia Kivipelto , et al. · 2020

Background Individuals in early dementia prevention trials may differ in how much they benefit from the interventions depending on their initial level of dementia risk. Using a composite risk score comprising health‐ and lifestyle factors …

P1‐291: THE ASSOCIATION BETWEEN AFFECTIVE SYMPTOMS AND ALZHEIMER'S DISEASE BIOMARKERS ACROSS THE DISEASE SPECTRUM Open

Leonie Banning, Inez H.G.B. Ramakers, Sebastian Koehler, Esther E. Bron, Frans R.J. Verhey , et al. · 2019

Affective symptoms occur in nearly all patients with Alzheimer's disease (AD) over the disease course and have profound prognostic consequences. The etiology of affective symptoms in AD is unclear. The aim of the current study is to examin…

O4‐06‐05: PROMOTING A BRAIN‐HEALTHY LIFESTYLE FOR REDUCING THE RISK OF COGNITIVE DECLINE AND DEMENTIA: LIBRA AND THE MIJNBREINCOACH (’MYBRAINCOACH’) PUBLIC HEALTH CAMPAIGN Open

Sebastian Koehler, Irene Heger, Kay Deckers, Marjolein de Vugt, Frans R.J. Verhey , et al. · 2019

Preventing or delaying dementia is a public health priority, but requires awareness in the target population and tailored strategies. We developed the ‘’LIfestyle for BRAin Health’’ (LIBRA) index to capture lifestyle-related dementia risk …

P2‐544: RELATIONSHIP BETWEEN EDUCATION, APOLIPOPROTEIN EPSILON 4 (<i>APOE*4</i>) AND COGNITIVE IMPAIRMENT IN DIVERSE ETHNO‐REGIONAL GROUPS: THE COSMIC COLLABORATION Open

Steve R. Makkar, Darren M. Lipnicki, Nicole A. Kochan, John D. Crawford, Henry Brodaty , et al. · 2019

Greater years of education are associated with a lower incidence of dementia and reduced magnitude of cognitive decline in late adulthood. Unclear is whether this association is linear or nonlinear, and whether there is a threshold level o…

[O1–01–04]: EARLY VASCULAR COGNITIVE IMPAIRMENT PREDICTS THE COURSE OF DEPRESSION AND APATHY AFTER STROKE: THE CASPER STUDY Open

Elles Douven, Sebastian Koehler, Syenna H.J. Schievink, Robert J. van Oostenbrugge, Julie Staals , et al. · 2017

Previous studies have found associations between cognitive impairment and depression and apathy after stroke, but due to the lack of longitudinal data, it remains unclear how changes in cognition influence the level of apathy and depressio…

k-BOOM: A Bayesian approach to ontology structure inference, with applications in disease ontology construction Open

Chris Mungall, Sebastian Koehler, Peter N. Robinson, Ian Holmes, Melissa Haendel · 2016

One strategy for building ontologies covering domains such as disease or anatomy is to weave together existing knowledge sources (databases, vocabularies and ontologies) into single cohesive whole. A first step in this process is to genera…

Combinations of Service Use Types of People With Early Cognitive Disorders Open

Niels Janssen, Ron Handels, Sebastian Koehler, Inez H.G.B. Ramakers, Renske Hamel , et al. · 2016

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