Sebastian Meller
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View article: Comparison of Virtual Non-Contrast Images Generated by Spectral Detector Computed Tomography and Conventional Computed Tomography Images of Histologically Confirmed Hepatic Pathologies in 28 Dogs
Comparison of Virtual Non-Contrast Images Generated by Spectral Detector Computed Tomography and Conventional Computed Tomography Images of Histologically Confirmed Hepatic Pathologies in 28 Dogs Open
Spectral detector computed tomography (SDCT) is an innovative imaging technique in veterinary medicine that utilises simultaneous data acquisition at different energy levels using two rows of detectors. This technique provides several inte…
View article: Comparison of the accuracy of conventional impression technique and an intraoral scanning system after crown preparation in canine teeth of dogs: a cadaver study
Comparison of the accuracy of conventional impression technique and an intraoral scanning system after crown preparation in canine teeth of dogs: a cadaver study Open
Objective This study aimed to compare digital impressions obtained by an intraoral scanner (IOS) with the dimensions of the corresponding stone model produced from conventional impressions and the original tooth to assess the accuracy of I…
View article: Computed Tomography Volumetric Measurements of Adrenal Glands in 26 Dogs Under One Year of Age: A Retrospective Study
Computed Tomography Volumetric Measurements of Adrenal Glands in 26 Dogs Under One Year of Age: A Retrospective Study Open
Limited data exist regarding the size and volume of adrenal glands in puppies; therefore, the present research aims to describe volumetric and traditional measurements of adrenal glands in computed tomography (CT) images of 26 dogs under 1…
View article: Spectral detector computed tomography imaging of histologically confirmed splenic pathologies in 30 canine patients: a comparison of virtual non-contrast images and true unenhanced images
Spectral detector computed tomography imaging of histologically confirmed splenic pathologies in 30 canine patients: a comparison of virtual non-contrast images and true unenhanced images Open
Introduction Spectral detector computed tomography (SDCT), a cutting-edge technique in veterinary medicine, offers various options for characterizing soft tissues. One such option is the virtual non-contrast (VNC) algorithm, which reconstr…
View article: Public perception of medical detection dogs and other COVID-19 testing strategies
Public perception of medical detection dogs and other COVID-19 testing strategies Open
The COVID-19 pandemic led to social restrictions, severely impacting many sectors, including the cultural and gastronomic sectors. To restore normality, various testing approaches were proposed, but public opinion and acceptance of these t…
View article: Application of a novel three-day repetitive transcranial magnetic stimulation protocol for the treatment of drug-resistant epilepsy in dogs: single-blinded randomised sham-controlled clinical trial
Application of a novel three-day repetitive transcranial magnetic stimulation protocol for the treatment of drug-resistant epilepsy in dogs: single-blinded randomised sham-controlled clinical trial Open
While the efficacy of repetitive transcranial magnetic stimulation (rTMS) has been explored in humans and, to a lesser extent, in dogs with epilepsy, further clinical studies are required to assess the potential antiseizure effect of this …
View article: Correlation of Mechanical Thresholds, Glasgow Composite Measure Pain Scale, and Sharp and Wheeler Grading Scale in Dogs with Acute Thoracolumbar Disc Extrusions
Correlation of Mechanical Thresholds, Glasgow Composite Measure Pain Scale, and Sharp and Wheeler Grading Scale in Dogs with Acute Thoracolumbar Disc Extrusions Open
In dogs with intervertebral disc extrusion (IVDE), the Glasgow Composite Measure Pain Scale—Short Form (GCMPS) and the Sharp and Wheeler Grading Scale (SWGS) are routinely used in the evaluation of pain (GCMPS) and neurological function (S…
View article: Canine Clinical Gait Analysis for Orthopedic and Neurological Disorders: An Inertial Deep-Learning Approach
Canine Clinical Gait Analysis for Orthopedic and Neurological Disorders: An Inertial Deep-Learning Approach Open
Canine gait analysis using wearable inertial sensors is gaining attention in veterinary clinical settings, as it provides valuable insights into a range of mobility impairments. Neurological and orthopedic conditions cannot always be easil…
View article: Evaluation of virtual non-contrast detector-based spectral CT images in comparison to true unenhanced images in 20 rabbits
Evaluation of virtual non-contrast detector-based spectral CT images in comparison to true unenhanced images in 20 rabbits Open
Introduction Spectral detector Computed Tomography (SDCT) enables generation of virtual non-contrast (VNC) images derived from a post-contrast scan, as previously investigated in healthy dogs. This technique is especially promising for awa…
View article: Scent dogs identify SARS-CoV-2-infections in respiratory samples from experimentally infected ferrets and hamsters—a pilot study
Scent dogs identify SARS-CoV-2-infections in respiratory samples from experimentally infected ferrets and hamsters—a pilot study Open
Rapid and sensitive diagnostic measures are a pre-requisite for the control of SARS-CoV-2 outbreaks. Dogs detect SARS-CoV-2-infected human individuals with high speed due to their extraordinary olfactory acuity. In the post-pandemic phase …
View article: Automated landmark-based cat facial analysis and its applications
Automated landmark-based cat facial analysis and its applications Open
Facial landmarks, widely studied in human affective computing, are beginning to gain interest in the animal domain. Specifically, landmark-based geometric morphometric methods have been used to objectively assess facial expressions in cats…
View article: Automated video-based pain recognition in cats using facial landmarks
Automated video-based pain recognition in cats using facial landmarks Open
View article: Canine idiopathic generalized tremor syndrome, immune-mediated?
Canine idiopathic generalized tremor syndrome, immune-mediated? Open
Idiopathic generalized tremor syndrome is a disorder characterized by an acute onset of full-body tremors, sometimes accompanied by vestibulo-cerebellar signs, that is responsive to treatment with corticosteroids. Although considered to ha…
View article: Comparative subcutaneous and submuscular implantation of an electroencephalography device for long term electroencephalographic monitoring in dogs
Comparative subcutaneous and submuscular implantation of an electroencephalography device for long term electroencephalographic monitoring in dogs Open
Background Implantable electroencephalography (EEG) recording devices have been used for ultra-long-term epilepsy monitoring both in clinical and home settings in people. Objective and accurate seizure detection and recording at home could…
View article: Behavioral comorbidities treatment by fecal microbiota transplantation in canine epilepsy: a pilot study of a novel therapeutic approach
Behavioral comorbidities treatment by fecal microbiota transplantation in canine epilepsy: a pilot study of a novel therapeutic approach Open
Introduction Anxiety and cognitive dysfunction are frequent, difficult to treat and burdensome comorbidities in human and canine epilepsy. Fecal microbiota transplantation (FMT) has been shown to modulate behavior in rodent models by alter…
View article: Re-evaluating the placebo response in recent canine dietary epilepsy trials
Re-evaluating the placebo response in recent canine dietary epilepsy trials Open
View article: Canine Electroencephalography Electrode Positioning Using a Neuronavigation System
Canine Electroencephalography Electrode Positioning Using a Neuronavigation System Open
Background: Studies in people suggest that surface electroencephalography (EEG) electrode positions vary across participants and that the consistency of these positions is electrode-, region-, and examiner-dependent. The aim was to investi…
View article: Comparing standard screening questionnaires of canine behavior for assessment of cognitive dysfunction
Comparing standard screening questionnaires of canine behavior for assessment of cognitive dysfunction Open
Background Canine cognitive dysfunction (CCD) is a common, yet underdiagnosed neurodegenerative disease affecting older dogs. Treatment is most effective when started early, so identifying mild cognitive decline in the earlier stages of th…
View article: Fecal supernatants from dogs with idiopathic epilepsy activate enteric neurons
Fecal supernatants from dogs with idiopathic epilepsy activate enteric neurons Open
Introduction Alterations in the composition and function of the gut microbiome have been reported in idiopathic epilepsy (IE), however, interactions of gut microbes with the enteric nervous system (ENS) in this context require further stud…
View article: The Postictal Phase in Canine Idiopathic Epilepsy: Semiology, Management, and Impact on the Quality of Life from the Owners’ Perspective
The Postictal Phase in Canine Idiopathic Epilepsy: Semiology, Management, and Impact on the Quality of Life from the Owners’ Perspective Open
Background: Dogs with idiopathic epilepsy experience not only the preictal and ictal seizure phases but also the postictal phase. To date, research has primarily focused on the preictal and ictal semiology and therapeutic control of ictal …
View article: Automated Landmark-Based Cat Facial Analysis and its Applications
Automated Landmark-Based Cat Facial Analysis and its Applications Open
Facial landmarks, widely studied in human affective computing, are beginning to gain interest in the animal domain. Specifically, landmark-based geometric morphometric methods have been used to objectively assess facial expressions in cats…
View article: Epilepsy is more than a simple seizure disorder: Parallels between human and canine cognitive and behavioural comorbidities
Epilepsy is more than a simple seizure disorder: Parallels between human and canine cognitive and behavioural comorbidities Open
Psychiatric and cognitive comorbidities have been known to play a major role in human epilepsy for a long time. People with epilepsy (PWE) frequently express signs of varying psychiatric and cognitive disorders affecting their quality and …
View article: Automated Pain Recognition in Cats using Facial Landmarks: Dynamics Matter
Automated Pain Recognition in Cats using Facial Landmarks: Dynamics Matter Open
Affective states are reflected in the facial expressions of all mammals. Facial behaviors linked to pain have attracted most of the attention so far in non-human animals, leading to the development of numerous instruments for evaluating pa…
View article: Epilepsy is more than a simple seizure disorder: Causal relationships between epilepsy and its comorbidities
Epilepsy is more than a simple seizure disorder: Causal relationships between epilepsy and its comorbidities Open
This review draws connections between the pathogenesis of canine epilepsy and its most commonly recognised comorbidities: cognitive impairment (CI), attention deficit hyperactivity disorder (ADHD)-like behaviour, fear and anxiety. Uni/bidi…
View article: Virtual non-contrast images of detector-based spectral computed tomography in dogs: a promising alternative to true non-contrast images in veterinary medicine
Virtual non-contrast images of detector-based spectral computed tomography in dogs: a promising alternative to true non-contrast images in veterinary medicine Open
Introduction In veterinary medicine, abdominal computer tomographic (CT) examinations regularly require a minimum of two scans, with a native scan (true unenhanced, TUE) as a reference for the subsequent contrast-enhanced CT scan (CECT). S…
View article: BrachySound: machine learning based assessment of respiratory sounds in dogs
BrachySound: machine learning based assessment of respiratory sounds in dogs Open
View article: Evaluation of the Submaximal Treadmill-Based Fitness Test in Six Brachycephalic Breeds—A Follow-Up Study
Evaluation of the Submaximal Treadmill-Based Fitness Test in Six Brachycephalic Breeds—A Follow-Up Study Open
Brachycephalic obstructive airway syndrome (BOAS) in dogs challenges veterinary surgeons both with a complex clinical picture as well as wide-ranging ways to diagnose the disease, often not easily implemented nor standardised in clinical p…
View article: BrachySound: Machine Learning Based Assessment of Respiratory Sounds in Dogs
BrachySound: Machine Learning Based Assessment of Respiratory Sounds in Dogs Open
The early and accurate diagnosis of brachycephalic obstructive airway syndrome (BOAS) in dogs is pivotal for effective treatment and enhanced canine well-being. Owners often do underestimate the severity of BOAS in their dogs. In addition,…
View article: Out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective
Out-of-hospital rescue medication in dogs with emergency seizure disorders: an owner perspective Open
Background Emergency seizure disorders such as status epilepticus and cluster seizures are unlikely to cease spontaneously while prolonged seizure activity become progressively more resistant to treatment. Early administration of rescue me…
View article: Long-lasting antiseizure effects of chronic intrasubthalamic convection-enhanced delivery of valproate
Long-lasting antiseizure effects of chronic intrasubthalamic convection-enhanced delivery of valproate Open
Intracerebral drug delivery is an experimental approach for the treatment of drug-resistant epilepsies that allows for pharmacological intervention in targeted brain regions. Previous studies have shown that targeted pharmacological inhibi…