Sebastian Mueller
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View article: Critical flicker frequency improves after alcohol detoxification and is associated with liver stiffness
Critical flicker frequency improves after alcohol detoxification and is associated with liver stiffness Open
BACKGROUND Critical flicker frequency (CFF) is a quantitative tool for assessing hepatic encephalopathy (HE), particularly minimal HE, which is associated with poor prognosis in liver cirrhosis. Alcohol-related liver disease (ALD) is a lea…
View article: Pharmacological Modulation of Liver and Spleen Stiffness in a Cirrhotic Rat Model
Pharmacological Modulation of Liver and Spleen Stiffness in a Cirrhotic Rat Model Open
In conclusion, combined LS and SS measurements may provide valuable non-invasive insights into patient responses and adherence to PH-lowering therapies.
View article: Hypoxia Longitudinally Correlates with Initial Extrinsic and Subsequent Intrinsic Vascularization of Collagen Elastin Matrix-Embedded Arteriovenous Loops in Experimental Rats
Hypoxia Longitudinally Correlates with Initial Extrinsic and Subsequent Intrinsic Vascularization of Collagen Elastin Matrix-Embedded Arteriovenous Loops in Experimental Rats Open
Purpose Tissue engineering techniques that allow the growth of vascularized tissue are currently being developed and characterized with the help of animal models such as the rat arteriovenous loop (AVL), a microvascular vessel loop that is…
View article: Evidence for alcohol-mediated hemolysis and erythrophagocytosis
Evidence for alcohol-mediated hemolysis and erythrophagocytosis Open
View article: Direct Ingestion of Oxidized Red Blood Cells (Efferocytosis) by Hepatocytes
Direct Ingestion of Oxidized Red Blood Cells (Efferocytosis) by Hepatocytes Open
We here demonstrate that hepatocytes can directly ingest and degrade oxidized RBCs through efferocytosis, a process that can be also triggered by ethanol, heme and bilirubin. Our findings are highly suggestive for a novel mechanism of hepa…
View article: Identification of diagnostic markers and molecular clusters of cuproptosis-related genes in alcohol-related liver disease based on machine learning and experimental validation
Identification of diagnostic markers and molecular clusters of cuproptosis-related genes in alcohol-related liver disease based on machine learning and experimental validation Open
View article: A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry
A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry Open
Background: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-associated cirrhosis by comparing …
View article: Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression
Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression Open
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirr…
View article: Functional and Radiologic Outcomes of Degenerative Versus Traumatic Full-Thickness Rotator Cuff Tears Involving the Supraspinatus Tendon
Functional and Radiologic Outcomes of Degenerative Versus Traumatic Full-Thickness Rotator Cuff Tears Involving the Supraspinatus Tendon Open
Background: Arthroscopic rotator cuff repair (ARCR) is among the most commonly performed orthopaedic procedures. Several factors—including age, sex, and tear severity—have been identified as predictors for outcome after repair. The influen…
View article: Confounders of Serum Phosphatidylethanol: Role of Red Blood Cell Turnover and Cirrhosis
Confounders of Serum Phosphatidylethanol: Role of Red Blood Cell Turnover and Cirrhosis Open
We here demonstrate that alcohol elimination is decreased in patients with liver cirrhosis. In patients with cirrhosis, PEth levels are both affected in opposite directions by enhanced red blood cell turnover and elevated alcohol levels. O…
View article: Liver stiffness in pregnant women with intrahepatic cholestasis of pregnancy: A case control study
Liver stiffness in pregnant women with intrahepatic cholestasis of pregnancy: A case control study Open
Metabolic-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases worldwide. In recent years, the occurrence rate of MAFLD has been on the rise, mainly due to lifestyle changes, high-calorie diets, and imbal…
View article: Accuracy of spleen stiffness measurement for the diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a systematic review and individual patient data meta-analysis
Accuracy of spleen stiffness measurement for the diagnosis of clinically significant portal hypertension in patients with compensated advanced chronic liver disease: a systematic review and individual patient data meta-analysis Open
View article: Non‐invasive diagnosis of alcohol‐related steatohepatitis in patients ongoing alcohol withdrawal based on cytokeratin 18 and transient elastography
Non‐invasive diagnosis of alcohol‐related steatohepatitis in patients ongoing alcohol withdrawal based on cytokeratin 18 and transient elastography Open
Summary Background and Aims The diagnosis of alcoholic steatohepatitis (ASH) is based on liver biopsy, which is costly and invasive with non‐negligible morbidity. The aim of this study was to evaluate the accuracy of circulating cytokerati…
View article: PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL
PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL Open
The single nucleotide polymorphism I148M of the lipase patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an unfavorable prognosis in alcoholic and non-alcoholic steatohepatitis (ASH, NASH), with progression to live…
View article: Editorial: Alcohol-associated liver disease—From pathogenesis to treatment
Editorial: Alcohol-associated liver disease—From pathogenesis to treatment Open
EDITORIAL article Front. Physiol., 20 October 2022Sec. Gastrointestinal Sciences Volume 13 - 2022 | https://doi.org/10.3389/fphys.2022.1060812
View article: Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study
Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study Open
Objective Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in …
View article: Novel insights into alcoholic liver disease: Iron overload, iron sensing and hemolysis
Novel insights into alcoholic liver disease: Iron overload, iron sensing and hemolysis Open
The liver is the major target organ of continued alcohol consumption at risk and resulting alcoholic liver disease (ALD) is the most common liver disease worldwide. The underlying molecular mechanisms are still poorly understood despite de…
View article: Cell-to-Cell Communications in Alcohol-Associated Liver Disease
Cell-to-Cell Communications in Alcohol-Associated Liver Disease Open
This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to liver injury development. The information exchange between various cell types may promote en…
View article: Clinical, histological and molecular profiling of different stages of alcohol-related liver disease
Clinical, histological and molecular profiling of different stages of alcohol-related liver disease Open
Objective Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and …
View article: The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis
The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis Open
The host genetic background for hepatocellular carcinoma (HCC) is incompletely understood. We aimed to determine if four germline genetic polymorphisms, rs429358 in apolipoprotein E ( APOE ), rs2642438 in mitochondrial amidoxime reducing c…
View article: Bone morphogenetic protein 6–mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron-sensing pathway in vitro
Bone morphogenetic protein 6–mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron-sensing pathway in vitro Open
Liver sinusoidal endothelial cell-derived bone morphogenetic protein 6 (BMP6) and the BMP6-small mothers against decapentaplegic homolog (SMAD) signaling pathway are essential for the expression of hepcidin, the secretion of which is consi…
View article: Direct modulation of hepatocyte hepcidin signaling by iron
Direct modulation of hepatocyte hepcidin signaling by iron Open
Iron directly blocks hepatocellular hepcidin signaling through the BMP/SMAD pathway but independent of STAT3. This mechanism may contribute to continued iron overload in many pathophysiological conditions ultimately causing a vicious cycle…
View article: A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers
A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers Open
View article: Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice
Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice Open
Mouse models are frequently used to study chronic liver diseases (CLDs). To assess their translational relevance, we quantified the similarity of commonly used mouse models to human CLDs based on transcriptome data. Gene‐expression data fr…
View article: New Therapeutic Approach for Intestinal Fibrosis Through Inhibition of pH-Sensing Receptor GPR4
New Therapeutic Approach for Intestinal Fibrosis Through Inhibition of pH-Sensing Receptor GPR4 Open
Background Patients suffering from inflammatory bowel diseases (IBDs) express increased mucosal levels of pH-sensing receptors compared with non-IBD controls. Acidification leads to angiogenesis and extracellular matrix remodeling. We aime…
View article: H2O2-mediated autophagy during ethanol metabolism
H2O2-mediated autophagy during ethanol metabolism Open
View article: Non-invasive Biomarkers of Liver Inflammation and Cell Death in Response to Alcohol Detoxification
Non-invasive Biomarkers of Liver Inflammation and Cell Death in Response to Alcohol Detoxification Open
Introduction Alcohol-related liver disease (ALD) represents the most common liver disease worldwide, however, the underlying molecular mechanisms are still poorly understood. Namely centrilobular inflammation and programmed cell death are …
View article: Markers of Intestinal Permeability Are Rapidly Improved by Alcohol Withdrawal in Patients with Alcohol-Related Liver Disease
Markers of Intestinal Permeability Are Rapidly Improved by Alcohol Withdrawal in Patients with Alcohol-Related Liver Disease Open
Changes in intestinal microbiome and barrier function are critical in the development of alcohol-related liver disease (ALD). Here, we determined the effects of a one-week alcohol withdrawal on parameters of intestinal barrier function in …
View article: S3-Leitlinie „Screening, Diagnose und Behandlung alkoholbezogener Störungen“
S3-Leitlinie „Screening, Diagnose und Behandlung alkoholbezogener Störungen“ Open
Zusammenfassung. Zielsetzung: Alkoholkonsum ist in Deutschland mit erheblichen gesundheitlichen und wirtschaftlichen Folgen assoziiert. Neben der Prävention spielen die Früherkennung und differentielle Behandlung von Betroffenen eine bedeu…
View article: Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis
Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis Open