Sebastian Musundi
YOU?
Author Swipe
View article: Exploring the P. falciparum antigens associated with reduced risk of malaria in pregnancy
Exploring the P. falciparum antigens associated with reduced risk of malaria in pregnancy Open
Plasmodium falciparum infection in pregnancy leads to substantial maternal and infant morbidity and mortality. Such an infection may result in placental malaria (PM) due to P. falciparum -infected red blood cells adhering to the placenta v…
View article: Full genome characterization of a Kenyan G8P[14] rotavirus strain suggests artiodactyl-to-human zoonotic transmission
Full genome characterization of a Kenyan G8P[14] rotavirus strain suggests artiodactyl-to-human zoonotic transmission Open
Background Rotavirus infections are a major cause of severe gastroenteritis in children. Human rotavirus strains with the unconventional G8P[14] genotype have sporadically been detected in diarrheic patients in different parts of the world…
View article: The genome sequence of varicella-zoster virus ( <i>Varicellovirus humanalpha3</i> ) obtained by metagenomics from a patient presenting with an exanthem rash
The genome sequence of varicella-zoster virus ( <i>Varicellovirus humanalpha3</i> ) obtained by metagenomics from a patient presenting with an exanthem rash Open
Here, we report a partial genome sequence of varicella-zoster virus, recovered through metagenomic sequencing from a skin lesion sample collected from a 31-year-old male from Mombasa, Kenya, in August 2024. Phylogenetic analysis placed thi…
View article: Development of Monoclonal Antibodies Against SARS-CoV-2 Nucleocapsid Protein for COVID-19 Antigen Detection
Development of Monoclonal Antibodies Against SARS-CoV-2 Nucleocapsid Protein for COVID-19 Antigen Detection Open
Background The coronavirus disease 2019 (COVID-19) pandemic underscored the global need for reliable diagnostic tools with quick turnaround time for effective patient management and mitigation of virus spread. This study aimed to express s…
View article: Emergence and transmission dynamics of the FY.4 Omicron variant in Kenya
Emergence and transmission dynamics of the FY.4 Omicron variant in Kenya Open
The recombinant FY.4 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant was first reported in Kenya in March 2023 and was the dominant circulating variant between April and July 2023. The variant was characterized by two …
View article: Emergence and transmission dynamics of the FY.4 Omicron variant in Kenya
Emergence and transmission dynamics of the FY.4 Omicron variant in Kenya Open
The recombinant FY.4 SARS-CoV-2 variant was first reported in Kenya in March 2023 and was the dominant circulating variant between April and July 2023. The variant was characterised by two important mutations: Y451H in the receptor binding…
View article: Genetic variation of the Plasmodium falciparum circumsporozoite protein in parasite isolates from Homabay County in Kenya
Genetic variation of the Plasmodium falciparum circumsporozoite protein in parasite isolates from Homabay County in Kenya Open
The Plasmodium falciparum Circumsporozoite Protein (PfCSP) has been used in developing the RTS,S, and R21 malaria vaccines. However, genetic polymorphisms within Pfcsp compromise the effectiveness of the vaccine. Thus, it is essential to c…
View article: Identification of conserved cross-species B-cell linear epitopes in human malaria: a subtractive proteomics and immuno-informatics approach targeting merozoite stage proteins
Identification of conserved cross-species B-cell linear epitopes in human malaria: a subtractive proteomics and immuno-informatics approach targeting merozoite stage proteins Open
Human malaria, caused by five Plasmodium species ( P. falciparum, P. vivax, P. malariae, P. ovale , and P. knowlesi ), remains a significant global health burden. While most interventions target P. falciparum , the species associated with …
View article: Metatranscriptomic analysis of wastewater sites reveals a high abundance of antimicrobial resistance genes from hospital wastewater
Metatranscriptomic analysis of wastewater sites reveals a high abundance of antimicrobial resistance genes from hospital wastewater Open
Objective This study analyzed the metatranscriptome of wastewater samples from different sites with a focus of identifying antibiotic resistance genes and the bacterial community. Methods Twenty-four wastewater samples were collected from …
View article: Identification of conserved cross-species B-cell linear epitopes in human malaria: A subtractive proteomics and immuno-informatics approach targeting merozoite stage proteins
Identification of conserved cross-species B-cell linear epitopes in human malaria: A subtractive proteomics and immuno-informatics approach targeting merozoite stage proteins Open
Human malaria, caused by five Plasmodium species ( P. falciparum, P. vivax, P. malariae, P. ovale , and P. knowlesi ), remains a significant global health burden. While most interventions target P. falciparum , the species associated with …
View article: Application of nanopore sequencing to identify antimicrobial resistance genes, mobile genetic elements and virulence factors in clinical isolates
Application of nanopore sequencing to identify antimicrobial resistance genes, mobile genetic elements and virulence factors in clinical isolates Open
The global health challenge posed by the emergence of antibiotic resistance pathogen is further exacerbated in African countries by the indiscriminate use of antibiotics, poor surveillance and lack of stewardship programs. To address this …
View article: Open Science in Kenya: Where Are We?
Open Science in Kenya: Where Are We? Open
According to the United Nations Educational, Scientific, and Cultural Organization (UNESCO), Open Science is the movement to make scientific research and data accessible to all. It has great potential for advancing science. At its core, it…
View article: Open Science in Kenya: Where are we?
Open Science in Kenya: Where are we? Open
According to the United Nations Educational, Scientific, and Cultural Organization (UNESCO), Open Science is the movement to make scientific research and data accessible to all. It has great potential for advancing science. At its core, it…
View article: Expression profile of odorant receptors in brain, gut and reproductive tissues in male and female Glossina morsitans morsitans
Expression profile of odorant receptors in brain, gut and reproductive tissues in male and female Glossina morsitans morsitans Open
Glossina morsitans morsitans are vectors of Animal African Trypanosomiasis (nagana) and Human African Trypanosomiasis (sleeping sickness). Glossina uses odorant receptors (Ors) expressed within the olfactory receptor neurons to identify ch…