Sebastian R. Merker
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View article: Extracellular vesicles from pancreatic cancer and its tumour microenvironment promote increased Schwann cell migration
Extracellular vesicles from pancreatic cancer and its tumour microenvironment promote increased Schwann cell migration Open
Background Pancreatic ductal adenocarcinoma (PDAC) exhibits a high frequency of neural invasion (NI). Schwann cells (SCs) have been shown to be reprogrammed to facilitate cancer cell migration and invasion into nerves. Since extracellular …
View article: Acquired epithelial WNT secretion drives niche independence of developing gastric cancer
Acquired epithelial WNT secretion drives niche independence of developing gastric cancer Open
Recent studies have shed light on the signaling pathways required for gastric tissue maintenance and how aberrations in these key pathways lead to gastric cancer development. Although it has been shown that the WNT pathway is important for…
View article: Sensitization of Patient-Derived Colorectal Cancer Organoids to Photon and Proton Radiation by Targeting DNA Damage Response Mechanisms
Sensitization of Patient-Derived Colorectal Cancer Organoids to Photon and Proton Radiation by Targeting DNA Damage Response Mechanisms Open
Pathological complete response (pCR) has been correlated with overall survival in several cancer entities including colorectal cancer. Novel total neoadjuvant treatment (TNT) in rectal cancer has achieved pathological complete response in …
View article: Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations
Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations Open
Using a stomach-specific CreERT2 system, we created mice that develop tumors with morphologic similarities to subtypes of human gastric cancer. These tumors have different patterns of local growth, metastasis, and response to therapeutic a…
View article: Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells Open
View article: Human gastric cancer modelling using organoids
Human gastric cancer modelling using organoids Open
Objective Gastric cancer is the second leading cause of cancer-related deaths and the fifth most common malignancy worldwide. In this study, human and mouse gastric cancer organoids were generated to model the disease and perform drug test…
View article: Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells Open
View article: Looking BAK again: Is an old acquaintance of innate immunity involved in the detection of herbivores?
Looking BAK again: Is an old acquaintance of innate immunity involved in the detection of herbivores? Open
The membrane-based receptor-like kinase BAK1 has been reported to interact with a number of other membrane-based receptors to contribute to a variety of signaling responses to exogenous and endogenous cues. These include brassinosteroid ho…
View article: Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability
Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability Open
The moderate anticancer effect of arginine deprivation in clinical trials has been linked to an induced argininosuccinate synthetase (ASS1) expression in initially ASS1-negative tumors, and ASS1-positive cancers are anticipated as non-resp…