Sebastian Rühling
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View article: Automated extraction of vertebral bone mineral density from imaging with various scan parameters: a cadaver study with correlation to quantitative computed tomography
Automated extraction of vertebral bone mineral density from imaging with various scan parameters: a cadaver study with correlation to quantitative computed tomography Open
Purpose To investigate lumbar vertebral volumetric bone mineral density (vBMD) from ex vivo opportunistic multi-detector computed tomography (MDCT) scans using different protocols, and compare it to dedicated quantitative CT (QCT) values f…
View article: Simulated low-dose multi-detector computed tomography: spatial effects on surrogate parameters of bone strength at the proximal femur
Simulated low-dose multi-detector computed tomography: spatial effects on surrogate parameters of bone strength at the proximal femur Open
Sparse sampling with SIR may enable drastic reductions of radiation exposure (up to 90% of original doses) for opportunistically measuring image-based surrogate parameters of bone strength.
View article: Opportunistic osteoporosis screening in intraoperative CT can accurately identify patients with low volumetric bone mineral density and osteoporosis during spine surgery
Opportunistic osteoporosis screening in intraoperative CT can accurately identify patients with low volumetric bone mineral density and osteoporosis during spine surgery Open
Purpose To evaluate the accuracy of opportunistic measurements of volumetric bone mineral density (vBMD) in intraoperative multi-detector CT (MDCT) scans, using preoperative MDCT as the reference. Methods This retrospective, single-center …
View article: Cervicothoracic volumetric bone mineral density assessed by opportunistic QCT may be a reliable marker for osteoporosis in adults
Cervicothoracic volumetric bone mineral density assessed by opportunistic QCT may be a reliable marker for osteoporosis in adults Open
Cervicothoracic vBMD may allow for determination of osteoporosis and prediction of VFs.
View article: The identification of low-pathogenic bacteria on removed spinal implants and implications for antimicrobial prophylaxis
The identification of low-pathogenic bacteria on removed spinal implants and implications for antimicrobial prophylaxis Open
View article: Reproducibility of CT-based opportunistic vertebral volumetric bone mineral density measurements from an automated segmentation framework
Reproducibility of CT-based opportunistic vertebral volumetric bone mineral density measurements from an automated segmentation framework Open
View article: Sex differences and age-related changes in vertebral body volume and volumetric bone mineral density at the thoracolumbar spine using opportunistic QCT
Sex differences and age-related changes in vertebral body volume and volumetric bone mineral density at the thoracolumbar spine using opportunistic QCT Open
Objectives To quantitatively investigate the age- and sex-related longitudinal changes in trabecular volumetric bone mineral density (vBMD) and vertebral body volume at the thoracolumbar spine in adults. Methods We retrospectively included…
View article: Long-term reproducibility of opportunistically assessed vertebral bone mineral density and texture features in routine clinical multi-detector computed tomography using an automated segmentation framework
Long-term reproducibility of opportunistically assessed vertebral bone mineral density and texture features in routine clinical multi-detector computed tomography using an automated segmentation framework Open
Opportunistic assessment of texture features in a single scanner environment using the presented CNN-based framework yields substantial reproducibility, outperforming vBMD reproducibility. Lowest scan-rescan variability was found for highe…
View article: Cost-effectiveness of opportunistic QCT-based osteoporosis screening for the prediction of incident vertebral fractures
Cost-effectiveness of opportunistic QCT-based osteoporosis screening for the prediction of incident vertebral fractures Open
Objectives Opportunistic quantitative computed tomography (oQCT) derived from non-dedicated routine CT has demonstrated high accuracy in diagnosing osteoporosis and predicting incident vertebral fractures (VFs). We aimed to investigate the…
View article: Incidental vertebral fracture prediction using neuronal network-based automatic spine segmentation and volumetric bone mineral density extraction from routine clinical CT scans
Incidental vertebral fracture prediction using neuronal network-based automatic spine segmentation and volumetric bone mineral density extraction from routine clinical CT scans Open
Objectives To investigate vertebral osteoporotic fracture (VF) prediction by automatically extracted trabecular volumetric bone mineral density (vBMD) from routine CT, and to compare the model with fracture prevalence-based prediction mode…
View article: DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact
DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact Open
The atypical protein tyrosine phosphatase enzyme, dual-specificity phosphate 15 (DUSP15) is thought to be activated by myelin regulatory factor (MyRF) and to have a role in oligodendrocyte differentiation. Here, we assess whether Dusp15 is…
View article: Proposed diagnostic volumetric bone mineral density thresholds for osteoporosis and osteopenia at the cervicothoracic spine in correlation to the lumbar spine
Proposed diagnostic volumetric bone mineral density thresholds for osteoporosis and osteopenia at the cervicothoracic spine in correlation to the lumbar spine Open
View article: Automated detection of the contrast phase in MDCT by an artificial neural network improves the accuracy of opportunistic bone mineral density measurements
Automated detection of the contrast phase in MDCT by an artificial neural network improves the accuracy of opportunistic bone mineral density measurements Open
View article: Patient-Specific Virtual Spine Straightening and Vertebra Inpainting: An Automatic Framework for Osteoplasty Planning
Patient-Specific Virtual Spine Straightening and Vertebra Inpainting: An Automatic Framework for Osteoplasty Planning Open
View article: Automated Opportunistic Osteoporosis Screening in Routine Computed Tomography of the Spine: Comparison With Dedicated Quantitative CT
Automated Opportunistic Osteoporosis Screening in Routine Computed Tomography of the Spine: Comparison With Dedicated Quantitative CT Open
Opportunistic osteoporosis screening in nondedicated routine computed tomography (CT) is of increasing importance. The purpose of this study was to compare lumbar volumetric bone mineral density (vBMD) assessed by a convolutional neural ne…