Sebastian Scheich
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View article: 327 | LONG‐TERM OUTCOME OF PATIENTS WITH RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA ACHIEVING CR USING BISPECIFIC ANTIBODIES
327 | LONG‐TERM OUTCOME OF PATIENTS WITH RELAPSED/REFRACTORY LARGE B‐CELL LYMPHOMA ACHIEVING CR USING BISPECIFIC ANTIBODIES Open
View article: Strategies for CRISPR-based knock-ins in primary human B cells and lymphoma cell lines
Strategies for CRISPR-based knock-ins in primary human B cells and lymphoma cell lines Open
Since its advent about ten years ago, the CRISPR-Cas9 system has been frequently used in biomedical applications. It has advanced various fields, and CRISPR-Cas9-based therapeutics have shown promising results in the treatment of specific …
View article: Inflammatory signaling pathways play a role in SYK inhibitor resistant AML
Inflammatory signaling pathways play a role in SYK inhibitor resistant AML Open
Trials have shown promising clinical activity of the selective SYK inhibitor entospletinib in patients with high expressing HOXA9/MEIS1 acute leukemias. As the development of resistance mechanisms is a common problem in the use of targeted…
View article: Epidemiology and outcomes of Candida spp. bloodstream infections in cancer patients: a comparative retrospective study from a German tertiary cancer center
Epidemiology and outcomes of Candida spp. bloodstream infections in cancer patients: a comparative retrospective study from a German tertiary cancer center Open
View article: Risk factors and outcome of Pseudomonas aeruginosa bloodstream infections (PABSI) in hematological patients: a single center retrospective cohort study
Risk factors and outcome of Pseudomonas aeruginosa bloodstream infections (PABSI) in hematological patients: a single center retrospective cohort study Open
Purpose Bloodstream infections caused by Pseudomonas aeruginosa (PABSI) in hematological patients are associated with high morbidity and mortality. We investigated the epidemiology, risk factors, and outcomes of PABSI at our center. Method…
View article: Risk factors and outcome of Pseudomonas aeruginosa bloodstream infections (PABSI) in hematological patients: A single center retrospective cohort study
Risk factors and outcome of Pseudomonas aeruginosa bloodstream infections (PABSI) in hematological patients: A single center retrospective cohort study Open
Purpose: Bloodstream infections caused by Pseudomonas aeruginosa (PABSI) in hematological patients are associated with high morbidity and mortality. We investigated the epidemiology, risk factors, and outcomes of PABSI at our center. Metho…
View article: Supplementary Table S2 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Table S2 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Disease score with corresponding features for the top disease per gene
View article: Supplementary Table S1 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Table S1 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Candidate gene list of selective dependencies identified analyzing DepMap dependency screen data
View article: Supplementary Figure S8 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S8 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
ATP1B1 expression across hematopoietic lineages
View article: Supplementary Figure S2 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S2 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
KO validation using TIDE PCR and cell cycle analysis
View article: Supplementary Material from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Material from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Merged file_supplementary figures and tables with legend
View article: Supplementary Table S3 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Table S3 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
MV4-11 and NB4 BioID_ATP1B1 and BioID_ATP1B3 results
View article: Supplementary Figure S9 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S9 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
ATP1B1 expression in CCLE highlighting Ewing sarcoma cell lines
View article: Supplementary Figure S10 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S10 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Cell viability assay in OCI-AML3 CTRL and TP53-KO cells treated with Nutlin-3.
View article: Supplementary Figure S4 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S4 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
NB4_BioID results
View article: Supplementary Figure S1 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S1 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Candidate gene selection based on the introduced features
View article: Supplementary Figure S7 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S7 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Isoform expression of ATP1B1
View article: Supplementary Figure S6 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S6 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
GSEA enrichments for the most significant biological processes Gene Ontology terms in ATP1B1 dependent and not dependent cell lines
View article: Supplementary Figure S3 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S3 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
In vivo data and validation of MV4-11_LUC cell models
View article: Data from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Data from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
Tissue-specific differences in the expression of paralog genes, which are not essential in most cell types due to the buffering effect of the partner pair, can make for highly selective gene dependencies. To identify selective paralogous t…
View article: Supplementary Figure S5 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Figure S5 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
ATP1B1 expression in CCLE and Treehouse data base
View article: Supplementary Table S4 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
Supplementary Table S4 from Targeting the Sodium–Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia Open
ATP1B1 gene expression across the BloodSpot.eu normal human hematopoiesis samples
View article: Supplementary Tables S1-S12 from Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
Supplementary Tables S1-S12 from Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas Open
Table S1. Brunello library sgRNA normalized read counts of IRF4 sorted CRISPR screens. Table S2. Segregation score of IRF4 sorted CRISPR screens. Table S3. Glycoproteomics in STT3A or STT3B KO cells. Table S4. Brunello sgRNA Library Normal…
View article: Supplementary Figures S1-10 from Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
Supplementary Figures S1-10 from Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas Open
Supplemental Figure 1. IRF4-GFP knock-in reporter cell lines. Supplemental Figure 2. IRF4-GFP CRISPR screen in adult T-cell lymphoma and screen controls. Supplemental Figure 3. The OST is essential for DLBCL. Supplemental Figure 4. The rol…
View article: Supplementary Tables S1-S12 from Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
Supplementary Tables S1-S12 from Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas Open
Table S1. Brunello library sgRNA normalized read counts of IRF4 sorted CRISPR screens. Table S2. Segregation score of IRF4 sorted CRISPR screens. Table S3. Glycoproteomics in STT3A or STT3B KO cells. Table S4. Brunello sgRNA Library Normal…
View article: Supplementary Figures S1-10 from Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
Supplementary Figures S1-10 from Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas Open
Supplemental Figure 1. IRF4-GFP knock-in reporter cell lines. Supplemental Figure 2. IRF4-GFP CRISPR screen in adult T-cell lymphoma and screen controls. Supplemental Figure 3. The OST is essential for DLBCL. Supplemental Figure 4. The rol…
View article: Supplementary Figure S14 from Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma
Supplementary Figure S14 from Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma Open
Inhibition of neddylation increases expression of BCR subunits
View article: Supplementary Figure S9 from Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma
Supplementary Figure S9 from Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma Open
Mutation of CD79A and CD79B glycosylated residues does not alter sensitivity to MMAE
View article: Supplementary Figure S10 from Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma
Supplementary Figure S10 from Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma Open
KLHL6 loss does not score as a negative regulator of surface CD79B or Pola-V sensitivity in CRISPR screens of ABC DLBCL cell lines and KLHL6 loss does not sensitize to MMAE
View article: Supplementary Table 1 from Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma
Supplementary Table 1 from Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma Open
CRISPR Screen Scores