Sebastian Sitaru
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View article: The dual non-competitive CXCR1/2 inhibitor ladarixin impairs neutrophil extravasation without altering intravascular adhesion
The dual non-competitive CXCR1/2 inhibitor ladarixin impairs neutrophil extravasation without altering intravascular adhesion Open
In many acute and chronic inflammatory disorders, recruitment of neutrophils plays a critical role in preventing disease severity and ensuring survival. On the other hand, neutrophil accumulation during inflammation can also favor disease …
View article: Public Information Needs and Interest in Specific Food and Drug Allergy Disorders in Germany (2022–2024): Google Search Engine Analysis
Public Information Needs and Interest in Specific Food and Drug Allergy Disorders in Germany (2022–2024): Google Search Engine Analysis Open
Background The prevalence of food and drug allergies has been steadily increasing in Germany. These conditions not only impair the quality of life of those affected but also place an additional burden on the health care system. At the same…
View article: Beyond Fitzpatrick: automated artificial intelligence-based skin tone analysis in dermatological patients
Beyond Fitzpatrick: automated artificial intelligence-based skin tone analysis in dermatological patients Open
Human skin tone is influenced by genetic, environmental, and cultural factors and plays a key role in dermatology due to variation in disease presentation across skin tones. The widely used Fitzpatrick scale, based on UV response, classifi…
View article: Remote evaluation of general skin diseases using three-dimensional total body photography: An observer agreement study
Remote evaluation of general skin diseases using three-dimensional total body photography: An observer agreement study Open
Despite being limited by recruitment bias, our study proves the feasibility of diagnosing general skin diseases with tele-3D TBP including a high physicians' and patients' acceptance. Further studies are needed to delineate its role in fut…
View article: Tracking Public Interest in Rare Diseases and Eosinophilic Disorders in Germany: Web Search Analysis
Tracking Public Interest in Rare Diseases and Eosinophilic Disorders in Germany: Web Search Analysis Open
Background Eosinophilia and hypereosinophilic syndrome (HES) are rare disorders grouped under the term hypereosinophilic disorders. They are diagnosed based on an increased number of eosinophils. They can also cause serious symptoms, inclu…
View article: Population-related needs and interest in food and drug allergies: a Google search engine analysis of specific allergy disorders in Germany (2022-2024) (Preprint)
Population-related needs and interest in food and drug allergies: a Google search engine analysis of specific allergy disorders in Germany (2022-2024) (Preprint) Open
BACKGROUND The prevalence of food and drug allergies is steadily increasing in Germany. Not only do those affected feel that their quality of life is restricted, but this also places an additional burden on the healthcare system. At the s…
View article: Emergence of <i>Trichophyton tonsurans</i>—A Retrospective Multicentre Study of the Dermatophyte Spectrum in Germany
Emergence of <i>Trichophyton tonsurans</i>—A Retrospective Multicentre Study of the Dermatophyte Spectrum in Germany Open
Background In mid‐2024, German media reported increasing fungal infections by Trichophyton tonsurans linked to visits to barbershops. However, epidemiological data confirming a rise in tinea capitis and tinea corporis due to Trichophyton t…
View article: Überbrückung der Versorgungslücke durch Telemedizin: Pilotstudie zur Akzeptanz und Nutzung der Teledermatologie bei Urtikaria
Überbrückung der Versorgungslücke durch Telemedizin: Pilotstudie zur Akzeptanz und Nutzung der Teledermatologie bei Urtikaria Open
Zusammenfassung Hintergrund Die chronische spontane Urtikaria (CSU) beeinträchtigt die Lebensqualität der Patienten erheblich. Trotz Fortschritten bei Diagnose und Therapie ist die Behandlung immer noch unzureichend. Die Telemedizin bietet…
View article: Objective actinic keratosis assessment by standardized clinical photography tool
Objective actinic keratosis assessment by standardized clinical photography tool Open
View article: Concomitant sarcoidosis, psoriasis, and eczema – immune patterns on the skin
Concomitant sarcoidosis, psoriasis, and eczema – immune patterns on the skin Open
Sarcoidosis is a rare and elusive chronic inflammatory disease. It can manifest itself in any organ, but preferentially affects the lungs and the skin. Our case of an elderly woman with cutaneous and pulmonary sarcoidosis presented with ex…
View article: Digitalising the past decades: automated ICD-10 coding of unstructured free text dermatological diagnoses
Digitalising the past decades: automated ICD-10 coding of unstructured free text dermatological diagnoses Open
Background Current digital medical databases record systematically coded diagnoses, but many legacy databases are full of hand-written, free text diagnoses, which can only be meaningfully analysed after mapping them to a coding system. Whi…
View article: Bridging the gap through telemedicine: Pilot study on the acceptance and use of teledermatology for urticaria
Bridging the gap through telemedicine: Pilot study on the acceptance and use of teledermatology for urticaria Open
Summary Background Chronic spontaneous urticaria (CSU) significantly impairs patients' quality of life. Despite advances in diagnosis and therapy, treatment is still unsatisfactory. Telemedicine offers a promising solution to improve treat…
View article: Next generation mycological diagnosis: Artificial intelligence‐based classifier of the presence of <i>Malassezia</i> yeasts in tape strip samples
Next generation mycological diagnosis: Artificial intelligence‐based classifier of the presence of <i>Malassezia</i> yeasts in tape strip samples Open
Background Malassezia yeasts are almost universally present on human skin worldwide. While they can cause diseases such as pityriasis versicolor, their implication in skin homeostasis and pathophysiology of other dermatoses is still unclea…
View article: Transforming Health Care Through Chatbots for Medical History-Taking and Future Directions: Comprehensive Systematic Review
Transforming Health Care Through Chatbots for Medical History-Taking and Future Directions: Comprehensive Systematic Review Open
Background The integration of artificial intelligence and chatbot technology in health care has attracted significant attention due to its potential to improve patient care and streamline history-taking. As artificial intelligence–driven c…
View article: Burden of atopic dermatitis in Europe: A population‐centred approach leveraging web search data in 21 European countries
Burden of atopic dermatitis in Europe: A population‐centred approach leveraging web search data in 21 European countries Open
Background The complexity, high prevalence, and substantial personal and socioeconomic burden collectively render atopic dermatitis (AD) a major public health concern. Using crowdsourced Internet data has the potential to provide unique in…
View article: Dilemmas of nomenclature: Web search analysis reveals European preferences in atopic skin diseases
Dilemmas of nomenclature: Web search analysis reveals European preferences in atopic skin diseases Open
Atopic dermatitis (AD) or atopic eczema (AE) is a complex chronic inflammatory skin disease with a high prevalence and disease burden.1 The nomenclature for this condition has long been the subject of controversial debate within the medica…
View article: Transforming Health Care Through Chatbots for Medical History-Taking and Future Directions: Comprehensive Systematic Review (Preprint)
Transforming Health Care Through Chatbots for Medical History-Taking and Future Directions: Comprehensive Systematic Review (Preprint) Open
BACKGROUND The integration of artificial intelligence and chatbot technology in health care has attracted significant attention due to its potential to improve patient care and streamline history-taking. As artificial intelligence–driven …
View article: Automatische Körperteil‐Identifikation in dermatologischen klinischen Bildern durch maschinelles Lernen
Automatische Körperteil‐Identifikation in dermatologischen klinischen Bildern durch maschinelles Lernen Open
Zusammenfassung Hintergrund Dermatologische Erkrankungen sind in allen Bevölkerungsgruppen weit verbreitet. Das betroffene Körperteil ist für ihre Diagnose, Therapie und Forschung von Bedeutung. Die automatische Identifizierung der abgebil…
View article: Social media to monitor prevalent diseases: Hay fever and Twitter activity in Germany
Social media to monitor prevalent diseases: Hay fever and Twitter activity in Germany Open
To the Editor, Allergic rhinitis (AR), also known as hay fever, is the most common allergic disease worldwide, affecting up to 30% of the global population.1 The analysis of publicly available, population-based data can be beneficial for n…
View article: Automatic body part identification in real‐world clinical dermatological images using machine learning
Automatic body part identification in real‐world clinical dermatological images using machine learning Open
Summary Background Dermatological conditions are prevalent across all population sub‐groups. The affected body part is of importance to their diagnosis, therapy, and research. The automatic identification of body parts in dermatological cl…
View article: Therapeutic inhibition of CXCR1/2: where do we stand?
Therapeutic inhibition of CXCR1/2: where do we stand? Open
View article: Assessing the national burden of allergic asthma by web-search data, pollen counts, and drug prescriptions in Germany and Sweden
Assessing the national burden of allergic asthma by web-search data, pollen counts, and drug prescriptions in Germany and Sweden Open
Our analysis offers population-level insights about this complex disease by reporting its needs and establishing the correlation to pollen counts, which enables a targeted approach in the public health management of allergic asthma. Local …
View article: Outlier detection in dermatology: Performance of different convolutional neural networks for binary classification of inflammatory skin diseases
Outlier detection in dermatology: Performance of different convolutional neural networks for binary classification of inflammatory skin diseases Open
Background Artificial intelligence (AI) and convolutional neural networks (CNNs) represent rising trends in modern medicine. However, comprehensive data on the performance of AI practices in clinical dermatologic images are non‐existent. F…
View article: Nonfungible tokens (NFTs) in dermatology and health care: A guide for health care professionals
Nonfungible tokens (NFTs) in dermatology and health care: A guide for health care professionals Open
A nonfungible token (NFT) represents an arbitrary piece of information, which can be created and exchanged on a blockchain, a type of public ledger secured by cryptographic algorithms. NFTs offer the possibility of leveraging blockchain te…
View article: Successful treatment of pyoderma gangrenosum with Janus kinase 1/2 inhibition
Successful treatment of pyoderma gangrenosum with Janus kinase 1/2 inhibition Open
Pyoderma gangrenosum (PG) is a rare, autoinflammatory disease leading to painful, hard‐to‐treat ulcers. Besides systemic glucocorticoids, a plethora of classic immunosuppressants, biologics and small molecules have been reported to improve…
View article: Munich atopy prediction study (MAPS): protocol for a prospective birth cohort addressing clinical and molecular risk factors for atopic dermatitis in early childhood
Munich atopy prediction study (MAPS): protocol for a prospective birth cohort addressing clinical and molecular risk factors for atopic dermatitis in early childhood Open
Introduction The pathogenesis of atopic diseases is highly complex, and the exact mechanisms leading to atopic dermatitis (AD) onset in infants remain mostly enigmatic. In addition to an interdependent network of components of skin develop…
View article: Netzwerkanalysen als nützliche Ergänzung konventioneller Statistik
Netzwerkanalysen als nützliche Ergänzung konventioneller Statistik Open
View article: CXCR1/2 inhibition in neutrophil recruitment
CXCR1/2 inhibition in neutrophil recruitment Open
Neutrophile Granulozyten spielen eine entscheidende Rolle im angeborenen Immunsystem und sind die ersten Zellen, die bei akuter Entzündung ins Gewebe rekrutiert werden. Dafür migrieren sie aus den Gefäßen ins Gewebe. Selectine sind zuständ…