Explanipedia

EndoCompass Project: Research Roadmap for Growth Disorders Open

M. Tauber, Sébastien G. Bouret, Assumpta Caixàs, Andrew Dauber, Éloïse Giabicani , et al. · 2025

Background: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal im…

Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period Open

Pierre-Yves Barelle, Fabienne Schaller, Émilie Caron, Philippe Ciofi, Françoise Muscatelli , et al. · 2025

The hypothalamus is crucial for regulating essential bodily functions, including energy balance. It is an exceedingly complex and heterogeneous brain region that contains a variety of neuronal systems that are interconnected with each othe…

Metabolic hormones, artificial sweeteners and the development of hypothalamic circuits controlling appetite Open

Sébastien G. Bouret · 2025

International audience

EndoCompass project: research roadmap for growth disorders Open

Evelien Gevers, Anita C. S. Hokken‐Koelega, M. Tauber, Gerhard Binder, Elena G. Bochukova , et al. · 2025

Background Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impa…

Vesicle-mediated oxytocin release drives melanocortin circuit maturation during a neonatal critical period Open

Pierre-Yves Barelle, Fabienne Schaller, Soyoung Park, Émilie Caron, Jessica Klucznik , et al. · 2025

The hypothalamus is crucial for regulating essential bodily functions, including energy balance. It is an exceedingly complex and heterogeneous brain region that contains a variety of neuronal systems that are interconnected with each othe…

Investigation of a mouse model of Prader-Willi Syndrome with combined disruption of Necdin and Magel2 Open

Pierre-Yves Barelle, Alicia Sicardi, Fabienne Schaller, Julie Buron, Denis Becquet , et al. · 2025

Prader-Willi syndrome (PWS) is a multigenic disorder caused by the loss of 7 contiguous paternally expressed genes. Mouse models with inactivation of all PWS genes are lethal. KO mouse models for each candidate gene have been generated, bu…

Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits Open

Judith Estrada-Meza, Jasmine Videlo, Clara Bron, Adeline Duchampt, C. Saint-Béat , et al. · 2024

A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons Open

Laura Kuczynski-Noyau, Sixtine Karmann, Paolo Alberton, Inés Martínez‐Corral, Sreekala S. Nampoothiri , et al. · 2024

Investigation of a Novel Mouse Model of Prader-Willi Syndrome with Invalidation ofNecdinandMagel2 Open

Pierre-Yves Barelle, Alicia Sicardi, Fabienne Schaller, Julie Buron, Denis Becquet , et al. · 2024

Prader-Willi syndrome (PWS) is a multigenic disorder caused by the loss of seven contiguous paternally expressed genes. Mouse models with inactivation of all PWS genes are lethal. Knockout (KO) mouse models for each candidate gene were gen…

Maternal low-calorie sweetener consumption rewires hypothalamic melanocortin circuits via a gut microbial co-metabolite pathway Open

Soyoung Park, Amine Mohamed Belfoul, Marialetizia Rastelli, Alice Jang, Magali Monnoye , et al. · 2023

The prevalence of obesity and type 2 diabetes is growing at an alarming rate, including among pregnant women. Low-calorie sweeteners (LCSs) have increasingly been used as an alternative to sugar to deliver a sweet taste without the excessi…

The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology Open

Marcela Parra-Vargas, Sébastien G. Bouret, Jens C. Brüning, Egberto Gaspar de Moura, Theodore Garland , et al. · 2023

Below, we briefly describe the scientific evidence supporting the impact of litter size on adult physiology and outline a series of recommendations and guidelines to be implemented by investigators, funding agencies, editors in scientific …

Molecular control of the development of hypothalamic neurons involved in metabolic regulation Open

Sophie Croizier, Sébastien G. Bouret · 2022

Developmental programming of hypothalamic melanocortin circuits Open

Sébastien G. Bouret · 2022

Neonatal leptin antagonism improves metabolic programming of postnatally overnourished mice Open

Gustav Colldén, Émilie Caron, Sébastien G. Bouret · 2022

Signalisation impliquant la neuropiline dans les neurones sécrétant la GnRH Open

Charlotte Vanacker, Sébastien G. Bouret, Paolo Giacobini, Vincent Prévot · 2021

La survie d’une espèce dépend de deux processus intimement liés : la reproduction, d’une part, et l’équilibre entre les besoins énergétiques et l’approvisionnement en sources d’énergie par l’alimentation, d’autre part. Ces deux processus s…

Signalisation impliquant la neuropiline dans les neurones sécrétant la GnRH: Son rôle dans le déclenchement de la puberté Open

Charlotte Vanacker, Sébastien G. Bouret, Paolo Giacobini, Vincent Prévot · 2021

International audience

Defective autophagy in Sf1 neurons perturbs the metabolic response to fasting and causes mitochondrial dysfunction Open

Bérengère Coupé, Corinne Leloup, Kwame Asiedu, Julien Maillard, Luc Pénicaud , et al. · 2021

Defective Autophagy inSf1Neurons Perturbs the Metabolic Response to Fasting and Causes Mitochondrial Dysfunction Open

Bérengère Coupé, Corinne Leloup, Julien Maillard, Luc Pénicaud, Tamas L. Horváth , et al. · 2020

Objective The ventromedial nucleus of the hypothalamus (VMH) is a critical component of the forebrain pathways that regulate energy homeostasis. It also plays an important role in the metabolic response to fasting. However, the mechanisms …

Neuropilin‐1 expression in GnRH neurons regulates prepubertal weight gain and sexual attraction Open

Charlotte Vanacker, Sara Trova, Sonal Shruti, Filippo Casoni, Andrea Messina , et al. · 2020

Rebaudioside affords hepatoprotection ameliorating sugar sweetened beverage- induced nonalcoholic steatohepatitis Open

Dong Xi, Jashdeep Bhattacharjee, Rosa-Maria Salazar-Gonzalez, Soyoung Park, Alice Jang , et al. · 2020

Sugar-sweetened beverage consumption is a known independent risk factor for nonalcoholic steatohepatitis (NASH). Non-caloric sweeteners (NCS) are food additives providing sweetness without calories and are considered safe and/or not metabo…

The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates Open

Soyoung Park, Aleek Aintablian, Bérengère Coupé, Sébastien G. Bouret · 2020

SAT-LB104 Maternal Non-Nutritive Sweeteners Consumption Perturbs Development of Melanocortin Circuits Causing Long-Term Metabolic Alterations in the Offspring Open

So‐Young Park, Alice Jang, Josephine Lowy, Sébastien G. Bouret · 2020

Maternal Non-Nutritive Sweeteners Consumption Perturbs Development of Melanocortin Circuits Causing Long-Term Metabolic Alterations in the Offspring Soyoung Park1, Alice Jang1, Josephine Lowy1, Sebastien G Bouret2 1Developmental Neuroscien…

Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring Open

Soyoung Park, Alice Jang, Sébastien G. Bouret · 2020

The steady increase in the prevalence of obesity and associated type II diabetes mellitus is a major health concern, particularly among children. Maternal obesity represents a risk factor that contributes to metabolic perturbations in the …

Non-nutritive Sweeteners Induce Hypothalamic ER Stress Causing Abnormal Axon Outgrowth Open

Soyoung Park, Sunjay Sethi, Sébastien G. Bouret · 2019

With the prevalence of obesity, non-nutritive sweeteners (NNS) have been widely used as sugar substitutes as they deliver a sweet taste without excessive caloric load. However, it is increasingly recognized that NNS are not inert compounds…

Hypothalamic Structural and Functional Imbalances in Anorexia Nervosa Open

V. Florent, Marc Baroncini, Patrice Jissendi‐Tchofo, Renaud Lopes, Matthieu Vanhoutte , et al. · 2019

The hypothalamus contains integrative systems that support life, including physiological processes such as food intake, energy expenditure, and reproduction. Here, we show that anorexia nervosa (AN) patients, contrary to normal weight and …

Maternal Obesity-Induced Endoplasmic Reticulum Stress Causes Metabolic Alterations and Abnormal Hypothalamic Development in the Offspring Open

So‐Young Park, Alice Jang, Sébastien G. Bouret · 2019

The steady increase in the prevalence obesity and associated type II diabetes is a major health concern, particularly among children. Maternal obesity represents a risk factor that contributes to metabolic perturbations in the offspring. E…

OR12-1 Leptin Is Transported across the Mouse Placenta Open

Soyoung Park, Alice Jang, Hsiao‐Huei Wu, Alexandre Bonnin, Sébastien G. Bouret · 2019

The placenta is critical for mother-fetus physiological communication. It is particularly sensitive to changes in the nutritional and hormonal environments and can contribute to the programming of metabolic syndrome. Recent data, including…

Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice Open

Nicholas C. Woodward, Amanda L. Crow, Yang Zhang, Sam Epstein, Jaana Hartiala , et al. · 2019

Emerging evidence from epidemiological and animal studies suggests that exposure to traffic-related air pollutants and particulate matter less than 2.5 µm in diameter (PM 2.5 ) contributes to development of obesity and related metabolic ab…

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance Open

Agatha A. van der Klaauw, Sophie Croizier, Edson Mendes de Oliveira, Lukas Kurt Josef Stadler, Soyoung Park , et al. · 2019

Supplementary Material for: Hypothalamic Structural and Functional Imbalances in Anorexia Nervosa Open

V. Florent, Marc Baroncini, Patrice Jissendi‐Tchofo, Renaud Lopes, Matthieu Vanhoutte , et al. · 2019

The hypothalamus contains integrative systems that support life, including physiological processes such as food intake, energy expenditure, and reproduction. Here, we show that anorexia nervosa (AN) patients, contrary to normal weight and …

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