Sébastien Goutal
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View article: Premature aging and neuropathic behaviours induced by an acute low-dose exposure to a sarin surrogate
Premature aging and neuropathic behaviours induced by an acute low-dose exposure to a sarin surrogate Open
Acute poisoning from organophosphorus (OP) compounds induced a cholinergic toxidrome. Neurological complications may manifest weeks after the initial exposure, including muscle weakness and progressive loss of sensitivity. These symptoms m…
View article: Decreased opioid receptor availability and impaired neurometabolic coupling as signatures of morphine tolerance in male rats: A positron emission tomography study
Decreased opioid receptor availability and impaired neurometabolic coupling as signatures of morphine tolerance in male rats: A positron emission tomography study Open
Translational neuroimaging techniques are needed to address the impact of opioid tolerance on brain function and quantitatively monitor the impaired neuropharmacological response to opioids at the CNS level. A multiparametric PET study was…
View article: Brain glucose metabolism as a neuronal substrate of the abnormal behavioral response to stress in the mdx mouse, a model of Duchenne muscular dystrophy
Brain glucose metabolism as a neuronal substrate of the abnormal behavioral response to stress in the mdx mouse, a model of Duchenne muscular dystrophy Open
Duchenne muscular dystrophy (DMD) is associated with a range of cognitive and behavioral problems. Brain-related comorbidities show clinical heterogeneity depending on the position of the mutation within the multi-promoter dystrophin (DMD)…
View article: Imaging quantitative changes in blood-brain barrier permeability using [<sup>18</sup>F]2-fluoro-2-deoxy-sorbitol ([<sup>18</sup>F]FDS) PET in relation to glial cell recruitment in a mouse model of endotoxemia
Imaging quantitative changes in blood-brain barrier permeability using [<sup>18</sup>F]2-fluoro-2-deoxy-sorbitol ([<sup>18</sup>F]FDS) PET in relation to glial cell recruitment in a mouse model of endotoxemia Open
The quantitative relationship between the disruption of the blood-brain barrier (BBB) and the recruitment of glial cells was explored in a mouse model of endotoxemia. [ 18 F]2-Fluoro-2-deoxy-sorbitol ([ 18 F]FDS) PET imaging was used as a …
View article: Brain PET imaging using <sup>11</sup>C-flumazenil and <sup>11</sup>C-buprenorphine does not support the hypothesis of a mutual interaction between buprenorphine and benzodiazepines at the neuroreceptor level
Brain PET imaging using <sup>11</sup>C-flumazenil and <sup>11</sup>C-buprenorphine does not support the hypothesis of a mutual interaction between buprenorphine and benzodiazepines at the neuroreceptor level Open
Among opioids, buprenorphine presents a favorable safety profile with a limited risk of respiratory depression. However, fatalities have been reported when buprenorphine is combined to a benzodiazepine. Potentiation of buprenorphine intera…
View article: Targeted Attacks: Redefining Spear Phishing and Business Email Compromise
Targeted Attacks: Redefining Spear Phishing and Business Email Compromise Open
In today's digital world, cybercrime is responsible for significant damage to organizations, including financial losses, operational disruptions, or intellectual property theft. Cyberattacks often start with an email, the major means of co…
View article: Parametric imaging of P-glycoprotein function at the blood-brain barrier using kE,brain-maps generated from [11C]metoclopramide PET data in rats, nonhuman primates and humans
Parametric imaging of P-glycoprotein function at the blood-brain barrier using kE,brain-maps generated from [11C]metoclopramide PET data in rats, nonhuman primates and humans Open
Purpose PET imaging using [ 11 C]metoclopramide revealed the importance of P-glycoprotein (P-gp, ABCB1) in mediating the brain-to-blood efflux of substrates across the blood-brain barrier (BBB). In this work, the elimination rate constant …
View article: Validation of a pharmacological imaging challenge using 11C-buprenorphine and 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography to study the effects of buprenorphine to the rat brain
Validation of a pharmacological imaging challenge using 11C-buprenorphine and 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography to study the effects of buprenorphine to the rat brain Open
Aim Buprenorphine mainly acts as an agonist of mu-opioid receptors (mu-OR). High dose buprenorphine does not cause respiratory depression and can be safely administered to elicit typical opioid effects and explore pharmacodynamics. Acute b…
View article: Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging
Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging Open
Crizotinib is a tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer, but it is inefficient on brain metastases. Crizotinib is a substrate of the P-glycoprotein, and non-invasive nuclear imaging can be used to…
View article: Impact of Cytochrome Induction or Inhibition on the Plasma and Brain Kinetics of [11C]metoclopramide, a PET Probe for P-Glycoprotein Function at the Blood-Brain Barrier
Impact of Cytochrome Induction or Inhibition on the Plasma and Brain Kinetics of [11C]metoclopramide, a PET Probe for P-Glycoprotein Function at the Blood-Brain Barrier Open
[11C]metoclopramide PET imaging provides a sensitive and translational tool to explore P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological diseases are often treated with cytochrome (CYP) modulators …
View article: Abnormal Expression of Synaptic and Extrasynaptic GABAA Receptor Subunits in the Dystrophin-Deficient mdx Mouse
Abnormal Expression of Synaptic and Extrasynaptic GABAA Receptor Subunits in the Dystrophin-Deficient mdx Mouse Open
Duchenne muscular dystrophy (DMD) is a neurodevelopmental disorder primarily caused by the loss of the full-length Dp427 dystrophin in both muscle and brain. The basis of the central comorbidities in DMD is unclear. Brain dystrophin plays …
View article: Comparison of the Blood–Brain Barrier Transport and Vulnerability to P-Glycoprotein-Mediated Drug–Drug Interaction of Domperidone versus Metoclopramide Assessed Using In Vitro Assay and PET Imaging
Comparison of the Blood–Brain Barrier Transport and Vulnerability to P-Glycoprotein-Mediated Drug–Drug Interaction of Domperidone versus Metoclopramide Assessed Using In Vitro Assay and PET Imaging Open
Domperidone and metoclopramide are widely prescribed antiemetic drugs with distinct neurological side effects. The impact of P-glycoprotein (P-gp)-mediated efflux at the blood–brain barrier (BBB) on brain exposure and BBB permeation was co…
View article: Isotopic Radiolabeling of the Antiretroviral Drug [18F]Dolutegravir for Pharmacokinetic PET Imaging
Isotopic Radiolabeling of the Antiretroviral Drug [18F]Dolutegravir for Pharmacokinetic PET Imaging Open
Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegrav…
View article: Pharmacokinetic Imaging Using 99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats
Pharmacokinetic Imaging Using 99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats Open
Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. 99mTc-mebrofenin is a non-metabolized substrate of transporters expressed at the diff…
View article: Impact of Donepezil on Brain Glucose Metabolism Assessed Using [18F]2-Fluoro-2-deoxy-D-Glucose Positron Emission Tomography Imaging in a Mouse Model of Alzheimer’s Disease Induced by Intracerebroventricular Injection of Amyloid-Beta Peptide
Impact of Donepezil on Brain Glucose Metabolism Assessed Using [18F]2-Fluoro-2-deoxy-D-Glucose Positron Emission Tomography Imaging in a Mouse Model of Alzheimer’s Disease Induced by Intracerebroventricular Injection of Amyloid-Beta Peptide Open
Graphical Abstract [ 18 F]2-fluoro-2-deoxy-D-glucose ([ 18 F]FDG) PET imaging was performed in a mouse model of Alzheimer’s disease to investigate the impact of donepezil on brain glucose metabolism.
View article: [18F]2-Fluoro-2-deoxy-sorbitol PET Imaging for Quantitative Monitoring of Enhanced Blood-Brain Barrier Permeability Induced by Focused Ultrasound
[18F]2-Fluoro-2-deoxy-sorbitol PET Imaging for Quantitative Monitoring of Enhanced Blood-Brain Barrier Permeability Induced by Focused Ultrasound Open
Focused ultrasound in combination with microbubbles (FUS) provides an effective means to locally enhance the delivery of therapeutics to the brain. Translational and quantitative imaging techniques are needed to noninvasively monitor and o…
View article: [18F]2-fluoro-2-deoxy-sorbitol PET Imaging for Quantitative Estimation of Blood-brain Barrier Permeability in vivo
[18F]2-fluoro-2-deoxy-sorbitol PET Imaging for Quantitative Estimation of Blood-brain Barrier Permeability in vivo Open
Purpose The non-transported and non-metabolized sorbitol derivative [18F]2-fluoro-2-deoxy-sorbitol ([18F]FDS) can be straightforwardly obtained from chemical reduction of commercial [18F]2-deoxy-2-fluoro-D-…
View article: The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain
The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain Open
View article: The Pharmacokinetics of [18F]UCB-H Revisited in The Healthy Non-Human Primate Brain
The Pharmacokinetics of [18F]UCB-H Revisited in The Healthy Non-Human Primate Brain Open
Background Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used in vivo in rodent…
View article: Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [<sup>11</sup>C]erlotinib
Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [<sup>11</sup>C]erlotinib Open
P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict at the blood–brain barrier (BBB) the brain distribution of the majority of currently known molecularly targeted anticancer drugs. To improve brain delivery of dua…
View article: Comparative test-retest variability of outcome parameters derived from brain [18F]FDG PET studies in non-human primates
Comparative test-retest variability of outcome parameters derived from brain [18F]FDG PET studies in non-human primates Open
[18F]FDG test-retest studies in NHP protocols need to be conducted under well-standardized experimental conditions to assess and select the most reliable and reproducible quantification approach. Furthermore, the choice of the quantificati…
View article: Text Data Augmentation: Towards better detection of spear-phishing emails
Text Data Augmentation: Towards better detection of spear-phishing emails Open
Text data augmentation, i.e., the creation of new textual data from an existing text, is challenging. Indeed, augmentation transformations should take into account language complexity while being relevant to the target Natural Language Pro…
View article: Text Data Augmentation: Towards better detection of spear-phishing\n emails
Text Data Augmentation: Towards better detection of spear-phishing\n emails Open
Text data augmentation, i.e., the creation of new textual data from an\nexisting text, is challenging. Indeed, augmentation transformations should take\ninto account language complexity while being relevant to the target Natural\nLanguage …
View article: Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease
Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease Open
View article: Longitudinal characterization of cognitive and motor deficits in an excitotoxic lesion model of striatal dysfunction in non-human primates
Longitudinal characterization of cognitive and motor deficits in an excitotoxic lesion model of striatal dysfunction in non-human primates Open
View article: Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease
Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease Open
View article: Physical blood-brain barrier disruption induced by focused ultrasound does not overcome the transporter-mediated efflux of erlotinib
Physical blood-brain barrier disruption induced by focused ultrasound does not overcome the transporter-mediated efflux of erlotinib Open
View article: Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats
Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats Open
View article: P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of<sup>11</sup>C-Metoclopramide Across the Blood–Brain Barrier: A PET Study on Nonhuman Primates
P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of<sup>11</sup>C-Metoclopramide Across the Blood–Brain Barrier: A PET Study on Nonhuman Primates Open
PET imaging using radiolabeled avid substrates of the ATP-binding cassette (ABC) transporter P-glycoprotein (ABCB1) has convincingly revealed the role of this major efflux transporter in limiting the influx of its substrates from blood int…
View article: Positron Emission Tomography Imaging Reveals an Importance of Saturable Liver Uptake Transport for the Pharmacokinetics of Metoclopramide
Positron Emission Tomography Imaging Reveals an Importance of Saturable Liver Uptake Transport for the Pharmacokinetics of Metoclopramide Open
Positron emission tomography (PET) imaging using [ 11 C]metoclopramide, a P-glycoprotein (P-gp) substrate, was used to investigate the contribution of transport processes to metoclopramide liver clearance. The liver kinetics obtained after…