Sébastien Schaub
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View article: MUFASA: A Continuous-Time Stochastic Framework for Realistic Fluorescence Microscopy Simulation
MUFASA: A Continuous-Time Stochastic Framework for Realistic Fluorescence Microscopy Simulation Open
We present MUFASA (Multi-Protocol Unified Fluorescence-based Advanced Simulation Algorithm), a physically grounded, continuous-time simulator for super-resolution fluorescence microscopy. By modeling fluorophore dynamics using continuous-t…
View article: CSF flow measurement in the mesencephalic aqueduct using 2D cine phase-contrast MRI in dogs with communicating internal hydrocephalus, ventriculomegaly, and physiologic ventricular spaces
CSF flow measurement in the mesencephalic aqueduct using 2D cine phase-contrast MRI in dogs with communicating internal hydrocephalus, ventriculomegaly, and physiologic ventricular spaces Open
Background Brachycephalic dogs are overrepresented with ventricular enlargement. Cerebrospinal fluid (CSF) flow dynamics are not completely understood. MRI techniques have been used for the visualization of CSF dynamics including phase-con…
View article: 3D Image Super-Resolution By Fluorophore Fluctuations And Ma-Tirf Microscopy Reconstruction (3D-Col0Rme)
3D Image Super-Resolution By Fluorophore Fluctuations And Ma-Tirf Microscopy Reconstruction (3D-Col0Rme) Open
International audience
View article: Physics-Inspired Generative Adversarial Modelling for Fluctuation-Based Super-Resolution Microscopy
Physics-Inspired Generative Adversarial Modelling for Fluctuation-Based Super-Resolution Microscopy Open
International audience
View article: Response of two temperate scleractinian corals to projected ocean warming and marine heatwaves
Response of two temperate scleractinian corals to projected ocean warming and marine heatwaves Open
The Mediterranean Sea is a hotspot of global change, particularly exposed to ocean warming and the increasing occurrence of marine heatwaves (MHWs). However, experiments based on long-term temperature data from the field are scarce. Here, …
View article: The <i>−KTS</i> splice variant of WT1 is essential for ovarian determination in mice
The <i>−KTS</i> splice variant of WT1 is essential for ovarian determination in mice Open
Sex determination in mammals depends on the differentiation of the supporting lineage of the gonads into Sertoli or pregranulosa cells that govern testis and ovary development, respectively. Although the Y-linked testis-determining gene Sr…
View article: Microtubule reorganization during mitotic cell division in the dinoflagellate<i>Ostreospis</i>cf.<i>ovata</i>
Microtubule reorganization during mitotic cell division in the dinoflagellate<i>Ostreospis</i>cf.<i>ovata</i> Open
Dinoflagellates are marine organisms that undergo seasonal explosive proliferation events known as algal blooms. Vegetative cell proliferation is a main contributing factor in these events. However, mechanistical understanding of mitosis a…
View article: Supplementary Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma
Supplementary Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma Open
Supplemental Figures S1 - S7 Supplemental Tables S1 - S17
View article: Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma
Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma Open
Inherent immune suppression represents a major challenge in the treatment of human cancer. The extracellular matrix molecule tenascin-C promotes cancer by multiple mechanisms, yet the roles of tenascin-C in tumor immunity are incompletely …
View article: Supplementary Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma
Supplementary Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma Open
Supplemental Figures S1 - S7 Supplemental Tables S1 - S17
View article: Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma
Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma Open
Inherent immune suppression represents a major challenge in the treatment of human cancer. The extracellular matrix molecule tenascin-C promotes cancer by multiple mechanisms, yet the roles of tenascin-C in tumor immunity are incompletely …
View article: Figure S4 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figure S4 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
F-actin and fibronectin stainings in M238P and M238R cells
View article: Figure S4 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figure S4 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
F-actin and fibronectin stainings in M238P and M238R cells
View article: Figure S8 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figure S8 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
BRAF inhibition drives collagen deposition and stiffening in M229 xenograft melanoma tumor
View article: Supplementary Table S1 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Supplementary Table S1 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
The table displays MS analysis of the matrisome between parental and BRAFi resistant melanoma cells
View article: Supplementary Table S1 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Supplementary Table S1 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
The table displays MS analysis of the matrisome between parental and BRAFi resistant melanoma cells
View article: Figure S7 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figure S7 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
Drug-protective effect of M229R melanoma cells-derived ECM
View article: Figure S1 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figure S1 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
Mesenchymal signature of BRAFi resistant melanoma cells
View article: Figures S2 and S3 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figures S2 and S3 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
Morphology and focal adhesions complexes of parental and BRAFi-resistant cells on hydrogels of various stiffness
View article: Figure S7 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figure S7 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
Drug-protective effect of M229R melanoma cells-derived ECM
View article: Figure S8 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figure S8 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
BRAF inhibition drives collagen deposition and stiffening in M229 xenograft melanoma tumor
View article: Supplementary Methods from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Supplementary Methods from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
Supplementary Methods
View article: Supplementary Methods from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Supplementary Methods from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
Supplementary Methods
View article: Data from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Data from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
Aberrant extracellular matrix (ECM) deposition and stiffening is a physical hallmark of several solid cancers and is associated with therapy failure. BRAF-mutant melanomas treated with BRAF and MEK inhibitors almost invariably develop resi…
View article: Figure S1 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figure S1 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
Mesenchymal signature of BRAFi resistant melanoma cells
View article: Figures S5 and S6 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figures S5 and S6 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
BRAF and MEK inhibition induces F-actin remodeling, YAP/MRTF activation and focal adhesion assembly in BRAF-mutant melanoma cells
View article: Figures S5 and S6 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figures S5 and S6 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
BRAF and MEK inhibition induces F-actin remodeling, YAP/MRTF activation and focal adhesion assembly in BRAF-mutant melanoma cells
View article: Data from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Data from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
Aberrant extracellular matrix (ECM) deposition and stiffening is a physical hallmark of several solid cancers and is associated with therapy failure. BRAF-mutant melanomas treated with BRAF and MEK inhibitors almost invariably develop resi…
View article: Figures S2 and S3 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
Figures S2 and S3 from A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma Open
Morphology and focal adhesions complexes of parental and BRAFi-resistant cells on hydrogels of various stiffness
View article: Fluorescence image deconvolution microscopy via generative adversarial learning (FluoGAN)
Fluorescence image deconvolution microscopy via generative adversarial learning (FluoGAN) Open
We propose FluoGAN, an unsupervised hybrid approach combining the physical modelling of fluorescence microscopy timelapse acquisitions with a generative adversarial learning procedure for the problem of image deconvolution. Differently fro…