Sebastian Maurer‐Stroh
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View article: Fish isoallergens and variants: database compilation, in silico allergenicity prediction challenges, and epitope-based threshold optimization
Fish isoallergens and variants: database compilation, in silico allergenicity prediction challenges, and epitope-based threshold optimization Open
Introduction Fish is a major food allergy trigger with a complex variety of allergenic protein isoforms and vast species diversity exhibiting variable allergenicity. This is the first study to systematically compile fish isoallergen and va…
View article: Nuclear-cytoplasmic translocation of MCIDAS couples transcription with massive de novo centriole biogenesis in multiciliated cells
Nuclear-cytoplasmic translocation of MCIDAS couples transcription with massive de novo centriole biogenesis in multiciliated cells Open
Multiciliated cells (MCCs) bear numerous motile cilia that drive fluid flow, but how numerous centrioles for multiciliation are generated has remained unresolved. Here, we report that the "master" MCC transcriptional regulator, MCIDAS, moo…
View article: Wastewater surveillance for early pathogen detection in Asia
Wastewater surveillance for early pathogen detection in Asia Open
Wastewater surveillance (WS) has emerged as an important population-based surveillance tool for early pathogen detection to inform timely public health action. Despite global guidance to initiate WS programming in Asia, the priorities and …
View article: Investigating the effectiveness of multimodal data in forecasting SARS-COV-2 case surges
Investigating the effectiveness of multimodal data in forecasting SARS-COV-2 case surges Open
The COVID-19 pandemic response relied heavily on statistical and machine learning models to predict key outcomes such as case prevalence and fatality rates. These predictions were instrumental in enabling timely public health interventions…
View article: Non-synonymous ERG11 mutations in <i>M. restricta</i> and <i>M. arunalokei</i> : impact on azole susceptibility
Non-synonymous ERG11 mutations in <i>M. restricta</i> and <i>M. arunalokei</i> : impact on azole susceptibility Open
Malassezia are commensal lipid-dependent yeasts and opportunistic pathogens that cause superficial mycoses and systemic infection. Azole antifungals target cell wall ergosterol synthesis and are the first line of antifungal treatment. ERG1…
View article: SARS-CoV-2: lessons in virus mutation prediction and pandemic preparedness
SARS-CoV-2: lessons in virus mutation prediction and pandemic preparedness Open
The COVID-19 pandemic has prompted an unprecedented global response. In particular, extraordinary efforts have been dedicated toward monitoring and predicting variant emergence due to its huge impact, particularly for vaccine escape. Broad…
View article: Pathogen genomics for surveillance and outbreak investigations
Pathogen genomics for surveillance and outbreak investigations Open
Advances in sequencing technology have enabled whole genome sequencing of microorganisms, allowing their rapid identification and characterisation and measure of relatedness to the highest resolution possible. This facilitates the tracking…
View article: Rediscovering publicly available single-cell data with the DISCO platform
Rediscovering publicly available single-cell data with the DISCO platform Open
Single-cell RNA sequencing (scRNA-seq) has emerged as the key technique for studying transcriptomics at the single-cell level. In our previous work, we presented the DISCO database (https://www.immunesinglecell.org/) that integrates public…
View article: Using pathogen genomics to predict antigenic changes of influenza H3N2 virus
Using pathogen genomics to predict antigenic changes of influenza H3N2 virus Open
Influenza viruses evolve their antigenic phenotype in response to immune-driven selection, necessitating regular updates to the antigens used in influenza vaccines. Characterising antigenic change of influenza virus currently requires inte…
View article: A Machine Learning-Guided Approach to Navigate the Substrate Activity Scope of Galactose Oxidase: Application in the Conversion of Pharmaceutically Relevant Bulky Secondary Alcohols
A Machine Learning-Guided Approach to Navigate the Substrate Activity Scope of Galactose Oxidase: Application in the Conversion of Pharmaceutically Relevant Bulky Secondary Alcohols Open
Biocatalysis is increasingly being adopted in industry for producing important chemicals in a selective, efficient, and sustainable way. Engineering an enzyme can often confer it with an altered chemical scope, making it accessible to new …
View article: The Allergen Profile of Two Edible Insect Species—<i>Acheta domesticus</i> and <i>Hermetia illucens</i>
The Allergen Profile of Two Edible Insect Species—<i>Acheta domesticus</i> and <i>Hermetia illucens</i> Open
Scope Edible insect proteins are increasingly introduced as an alternative sustainable food source to address the world's need to feed the growing population. Tropomyosin is the main insect allergen; however, additional potential allergens…
View article: Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1)
Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) Open
The findings suggest imprinting of antibody responses that is shaped by the first vaccination (WT spike). Previous infection also affects the boosting effect of follow-up vaccination. Studies are needed to understand how to induce a robust…
View article: Positive-strand RNA viruses—a Keystone Symposia report
Positive-strand RNA viruses—a Keystone Symposia report Open
Positive-strand RNA viruses have been the cause of several recent outbreaks and epidemics, including the Zika virus epidemic in 2015, the SARS outbreak in 2003, and the ongoing SARS-CoV-2 pandemic. On June 18–22, 2022, researchers focusing…
View article: Towards multi-omics synthetic data integration
Towards multi-omics synthetic data integration Open
Across many scientific disciplines, the development of computational models and algorithms for generating artificial or synthetic data is gaining momentum. In biology, there is a great opportunity to explore this further as more and more b…
View article: Identification and semi-quantification of protein allergens in complex mixtures using proteomic and AllerCatPro 2.0 bioinformatic analyses: a proof-of-concept investigation
Identification and semi-quantification of protein allergens in complex mixtures using proteomic and AllerCatPro 2.0 bioinformatic analyses: a proof-of-concept investigation Open
The demand for botanicals and natural substances in consumer products has increased in recent years. These substances usually contain proteins and these, in turn, can pose a risk for immunoglobulin E (IgE)-mediated sensitization and allerg…
View article: Variant-Specific IgA Protects Against Omicron Infection
Variant-Specific IgA Protects Against Omicron Infection Open
Background The emergence of rapidly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, coupled with waning vaccine-induced immunity, has contributed to the rise of vaccine breakthrough infections. It is crucial…
View article: Genome-wide association study of heart failure in a multiethnic south-east asian cohort
Genome-wide association study of heart failure in a multiethnic south-east asian cohort Open
NMRC Heart failure (HF) is a leading cause of morbidity and mortality worldwide (1). While existing genome-wide association studies (GWAS) have yielded many different loci and causal genes, most of such studies has been conducted in Europe…
View article: Redirecting immune, lipid, and metabolic drivers of early cardiovascular disease: the RESET cohort study and randomized trial
Redirecting immune, lipid, and metabolic drivers of early cardiovascular disease: the RESET cohort study and randomized trial Open
Collaborative Grant funded programme that brings together a nationwide community of cardiovascular (CVD), metabolic, and digital health researchers, as well as clinicians across primary and tertiary care to study the immune, lipid and meta…
View article: Identifying repurposed drugs with moderate anti-influenza virus activity through computational prioritization of drug-target pairs
Identifying repurposed drugs with moderate anti-influenza virus activity through computational prioritization of drug-target pairs Open
Influenza A virus (IAV) causes up to five million cases of severe illness and half a million deaths worldwide each year. While there are a few clinically approved drugs for treating IAV, they are challenged by the rapid evolution of the vi…
View article: Application of AllerCatPro 2.0 for protein safety assessments of consumer products
Application of AllerCatPro 2.0 for protein safety assessments of consumer products Open
Foreign proteins are potentially immunogenic, and a proportion of these are able to induce immune responses that result in allergic sensitization. Subsequent exposure of sensitized subjects to the inducing protein can provoke a variety of …
View article: Artificial intelligence innovation in healthcare: Relevance of reporting guidelines for clinical translation from bench to bedside
Artificial intelligence innovation in healthcare: Relevance of reporting guidelines for clinical translation from bench to bedside Open
Artificial intelligence (AI) and digital innovation are transforming healthcare. Technologies such as machine learning in image analysis, natural language processing in medical chatbots and electronic medical record extraction have the pot…
View article: Erratum to “Impact of delta variant and vaccination on SARS-CoV-2 secondary attack rate among household close contacts” [The Lancet Regional Health – Western Pacific 17 (2021) 100299]
Erratum to “Impact of delta variant and vaccination on SARS-CoV-2 secondary attack rate among household close contacts” [The Lancet Regional Health – Western Pacific 17 (2021) 100299] Open
[This corrects the article DOI: 10.1016/j.lanwpc.2021.100299.].