Sébastien Violot
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View article: TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream
TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream Open
Tissue-nonspecific alkaline phosphatase (TNAP) is primarily known for its role in skeletal mineralization, through the hydrolysis of inorganic pyrophosphate (PPi). Here we demonstrate that TNAP-knockout mice exhibit liver steato…
View article: A new bacterial phospholipase D with specificity for phosphatidylethanolamine over phosphatidylcholine
A new bacterial phospholipase D with specificity for phosphatidylethanolamine over phosphatidylcholine Open
Phospholipases D (PLDs) are key enzymes involved in numerous processes in all living organisms. PLD catalyzes, notably, the hydrolysis of different phospholipids (PLs) generating phosphatidic acid (PA). PA is an important moiety at the cro…
View article: Structural and Functional Integration of Tissue-Nonspecific Alkaline Phosphatase Within the Alkaline Phosphatase Superfamily: Evolutionary Insights and Functional Implications
Structural and Functional Integration of Tissue-Nonspecific Alkaline Phosphatase Within the Alkaline Phosphatase Superfamily: Evolutionary Insights and Functional Implications Open
Phosphatases are enzymes that catalyze the hydrolysis of phosphate esters. They play critical roles in diverse biological processes such as extracellular nucleotide homeostasis, transport of molecules across membranes, intracellular signal…
View article: GMP Synthetase: Allostery, Structure, and Function
GMP Synthetase: Allostery, Structure, and Function Open
Glutamine amidotransferases (GATs) catalyze the hydrolysis of glutamine and transfer the generated ammonia to diverse metabolites. The two catalytic activities, glutaminolysis and the subsequent amination of the acceptor substrate, happen …
View article: Purine containing carbonucleoside phosphonate analogues as novel chemotype for Plasmodium falciparum Inhibition
Purine containing carbonucleoside phosphonate analogues as novel chemotype for Plasmodium falciparum Inhibition Open
View article: Purine Containing Carbonucleoside Phosphonate Analogues as Novel Chemotype for Plasmodium Falciparum Inhibition
Purine Containing Carbonucleoside Phosphonate Analogues as Novel Chemotype for Plasmodium Falciparum Inhibition Open
View article: Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium
Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium Open
View article: Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis
Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis Open
Glutamine amidotransferases, enzymes that transfer nitrogen from Gln to various cellular metabolites, are modular, with the amidotransferase (GATase) domain hydrolyzing Gln, generating ammonia and the acceptor domain catalyzing the additio…
View article: Exploring molecular determinants of <i>polysaccharide lyase family 6–1 enzyme</i> activity
Exploring molecular determinants of <i>polysaccharide lyase family 6–1 enzyme</i> activity Open
The polysaccharide lyase family 6 (PL6) represents one of the 41 polysaccharide lyase families classified in the CAZy database with the vast majority of its members being alginate lyases grouped into three subfamilies, PL6_1–3. To decipher…
View article: Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase
Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase Open
View article: Helices on interdomain interface couple catalysis in the ATPPase domain with allostery in<i>Plasmodium falciparum</i>GMP synthetase
Helices on interdomain interface couple catalysis in the ATPPase domain with allostery in<i>Plasmodium falciparum</i>GMP synthetase Open
GMP synthetase catalyzes the substitution of the C2 oxo-group of the purine base in XMP with an amino-group generating GMP, the last step in the biosynthesis of GMP. This reaction involves a series of catalytic events that include hydrolys…
View article: Mechanism of allostery and catalysis in <i>P. falciparum</i> GMP Synthetase
Mechanism of allostery and catalysis in <i>P. falciparum</i> GMP Synthetase Open
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View article: Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation
Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation Open