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View article: Evaluation of sampling methods for genomic surveillance of SARS-CoV-2 variants in aircraft wastewater: advancing global early-warning systems for future pandemics
Evaluation of sampling methods for genomic surveillance of SARS-CoV-2 variants in aircraft wastewater: advancing global early-warning systems for future pandemics Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing threat to global health. Wastewater-based surveillance (WBS) has proven to be an important tool for tracking the dissemination of SARS-CoV-2 variants of …
View article: Rhino-Orbital Hyalohyphomycosis - A Rare Presentation in an Immunocompetent Host
Rhino-Orbital Hyalohyphomycosis - A Rare Presentation in an Immunocompetent Host Open
Hyalohyphomycosis is an opportunistic infection of the subcutaneous tissue caused by hyaline fungi Hyphomycetes that form septate hyphae within tissue. Immunocompromised states and tropical climates are the main predisposing factors. Rhino…
View article: Evaluation of sampling methods for genomic surveillance of SARS-CoV-2 variants in aircraft wastewater samples
Evaluation of sampling methods for genomic surveillance of SARS-CoV-2 variants in aircraft wastewater samples Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing threat to global health. Wastewater-based surveillance (WBS) has proven to be an important tool for tracking the dissemination of SARS-CoV-2 variants of …
View article: Antimicrobial Susceptibility Patterns of Haemophilus influenzae and Streptococcus pneumoniae in Respiratory Tract Infections: A Retrospective Observational Real-world Database Study in India
Antimicrobial Susceptibility Patterns of Haemophilus influenzae and Streptococcus pneumoniae in Respiratory Tract Infections: A Retrospective Observational Real-world Database Study in India Open
Introduction: Antimicrobial Resistance (AMR) presents a major worldwide challenge to public health, leading to significant levels of illness and death in India. The rise in antibiotic prescriptions during the pandemic raised concerns over …
View article: Genomic surveillance of Canadian airport wastewater samples allows early detection of emerging SARS-CoV-2 lineages
Genomic surveillance of Canadian airport wastewater samples allows early detection of emerging SARS-CoV-2 lineages Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has shown wastewater (WW) surveillance to be an effective means of tracking the emergence of viral lineages which arrive by many routes of transmission including via…
View article: Genomic Surveillance of a Canadian Airport Wastewater Samples Allows Early Detection of Emerging SARS-CoV-2 Lineages
Genomic Surveillance of a Canadian Airport Wastewater Samples Allows Early Detection of Emerging SARS-CoV-2 Lineages Open
The SARS-CoV-2 pandemic has shown that wastewater (WW) surveillance is an effective means of tracking the emergence of viral lineages in communities, arriving by many routes including via transportation hubs. In Ontario, numerous municipal…
View article: Serum AZD7442 (tixagevimab–cilgavimab) concentrations and <i>in vitro</i><scp>IC<sub>50</sub></scp> values predict SARS‐CoV‐2 neutralising antibody titres
Serum AZD7442 (tixagevimab–cilgavimab) concentrations and <i>in vitro</i><span>IC<sub>50</sub></span> values predict SARS‐CoV‐2 neutralising antibody titres Open
Objectives The evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) necessitates rapid methods for assessing monoclonal antibody (mAb) potency against emerging variants. Authentic virus neutralisation assays are consid…
View article: Markerless dynamic tumor tracking (MDTT) radiotherapy using diaphragm as a surrogate for liver targets
Markerless dynamic tumor tracking (MDTT) radiotherapy using diaphragm as a surrogate for liver targets Open
Purpose To assess the feasibility of using the diaphragm as a surrogate for liver targets during MDTT. Methods Diaphragm as surrogate for markers: a dome‐shaped phantom with implanted markers was fabricated and underwent dual‐orthogonal fl…
View article: Comment on gmd-2023-7
Comment on gmd-2023-7 Open
Abstract. The Australian Bureau of Meteorology has developed a national hydrological projections (NHP) service for Australia. With the focus on hydrological change assessment, the NHP service aims at being complementary to climate projecti…
View article: Case series of medication-related osteonecrosis of the jaw (MRONJ) patients prescribed a drug holiday
Case series of medication-related osteonecrosis of the jaw (MRONJ) patients prescribed a drug holiday Open
The role of a drug holiday in the management of medication-related osteonecrosis of the jaw (MRONJ) remains controversial. Current UK guidance does not recommend this practice given the lack of conclusive evidence, and potential risk of sk…
View article: Continental-scale bias-corrected climate and hydrological projections for Australia
Continental-scale bias-corrected climate and hydrological projections for Australia Open
The Australian Bureau of Meteorology has developed a national hydrological projections (NHP) service for Australia. With the focus on hydrological change assessment, the NHP service aims at being complementary to climate projections work c…
View article: Supporting Methane Mitigation Efforts by Improving Urban-scale Methane Emission Estimates in Melbourne, Australia. Part 1: Modelling
Supporting Methane Mitigation Efforts by Improving Urban-scale Methane Emission Estimates in Melbourne, Australia. Part 1: Modelling Open
This study establishes a regional inverse framework to refine methane (CH4) emission inventories for Melbourne, Australia. Methane is a long-lived greenhouse gas and the second most significant contributor to radiative forcing from greenho…
View article: 33 Cardiac MRI thresholds for improvement in pulmonary arterial hypertension
33 Cardiac MRI thresholds for improvement in pulmonary arterial hypertension Open
Introduction Cardiac MRI (CMR) is the gold standard technique to assess bi-ventricular volumes and function and is increasingly being considered as an end-point in clinical studies. Currently, with the exception of right ventricle (RV) str…
View article: AZD7442 (Tixagevimab/Cilgavimab) for Post-Exposure Prophylaxis of Symptomatic Coronavirus Disease 2019
AZD7442 (Tixagevimab/Cilgavimab) for Post-Exposure Prophylaxis of Symptomatic Coronavirus Disease 2019 Open
Background This phase 3 trial assessed AZD7442 (tixagevimab/cilgavimab) for post-exposure prophylaxis against symptomatic coronavirus disease 2019 (COVID-19). Methods Adults without prior severe acute respiratory syndrome coronavirus 2 (SA…
View article: Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy
Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy Open
OBJECTIVES: We sought to define the role of norepinephrine and epinephrine in the development of cardiac hypertrophy and to determine whether the absence of circulating catecholamines alters the activation of downstream myocardial signalin…
View article: We Can Be Heroes: A Study of Mythistoric Genealogies in the Roman Republic
We Can Be Heroes: A Study of Mythistoric Genealogies in the Roman Republic Open
Mythistoric genealogies, the claims of divine or heroic ancestry made by the Roman elite during the Republic, provide an alternative lens through which to understand social constructs and political experiences of Romans. However, the relat…
View article: Discovery of Selective <i>Toxoplasma gondii</i> Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis
Discovery of Selective <i>Toxoplasma gondii</i> Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis Open
A safer treatment for toxoplasmosis would be achieved by improving the selectivity and potency of dihydrofolate reductase (DHFR) inhibitors, such as pyrimethamine (1), for Toxoplasma gondii DHFR ( TgDHFR) relative to human DHFR ( hDHFR). W…
View article: On the calibration of a WEC-Sim model for heaving point absorbers
On the calibration of a WEC-Sim model for heaving point absorbers Open
The outcomes of reliability based design\nmethods applied to wave energy converters (WECs) in the\nearly stages of development depend heavily on the\nuncertainty in the variables used to determine the loads\nacting on, and responses of, de…
View article: Toxoplasma gondii TS-DHFR in complex with selective inhibitor 3
Toxoplasma gondii TS-DHFR in complex with selective inhibitor 3 Open
A safer treatment for toxoplasmosis would be achieved by improving the selectivity and potency of dihydrofolate reductase (DHFR) inhibitors, such as pyrimethamine (1), for Toxoplasma gondii DHFR ( TgDHFR) relative to human DHFR ( hDHFR). W…
View article: System for the Transfer of 2D Material
System for the Transfer of 2D Material Open
A setup for transferring 2D materials was design and assembled. Key features of the setup are: (i) microscope and translational/rotational stages for aligning 2D material samples and target substrates, (ii) force sensor for force controlle…
View article: Mycobacterium goodii Related Breast Implant Infection: First Case and Literature Review
Mycobacterium goodii Related Breast Implant Infection: First Case and Literature Review Open
A 46-year-old Caucasian female was diagnosed with invasive lobular carcinoma of the left breast.She underwent mastectomy and placement of a silicone breast implant as a single-stage procedure.Two weeks after surgery, she developed erythema…
View article: Discovery of Potent and Selective Leads against <i>Toxoplasma gondii</i> Dihydrofolate Reductase via Structure-Based Design
Discovery of Potent and Selective Leads against <i>Toxoplasma gondii</i> Dihydrofolate Reductase via Structure-Based Design Open
Current treatment of toxoplasmosis targets the parasite's folate metabolism through inhibition of dihydrofolate reductase (DHFR). The most widely used DHFR antagonist, pyrimethamine, was introduced over 60 years ago and is associated with …