Seema Husain
YOU?
Author Swipe
View article: Transcriptional Profiling Defines Unique Subtypes of Transit Amplifying Neural Progenitors Within the Neonatal Mouse Subventricular Zone
Transcriptional Profiling Defines Unique Subtypes of Transit Amplifying Neural Progenitors Within the Neonatal Mouse Subventricular Zone Open
While significant progress has been made in understanding the heterogeneity of Neural Stem Cells (NSCs), our understanding of similar heterogeneity among the more abundant transit amplifying progenitors is lagging. Our work on the neural p…
View article: Transcriptional profiling defines unique subtypes of transit amplifying neural progenitors within the neonatal mouse subventricular zone
Transcriptional profiling defines unique subtypes of transit amplifying neural progenitors within the neonatal mouse subventricular zone Open
While significant progress has been made in understanding the heterogeneity of Neural Stem Cells (NSCs), our understanding of similar heterogeneity among the more abundant transit amplifying progenitors is lagging. Our work on the neural p…
View article: Inflammasome activation differences underpin different <i>Mycobacterium tuberculosis</i> infection outcomes
Inflammasome activation differences underpin different <i>Mycobacterium tuberculosis</i> infection outcomes Open
The clinical outcome of Mycobacterium tuberculosis (Mtb) infection ranges from latent/non-progressive disease to active/progressive tuberculosis (TB), but the cellular events contributing to these variable outcomes remain unknown. Here, we…
View article: Novel Hyperplastic Expansion of White Adipose Tissue Underlies the Metabolically Healthy Obese Phenotype of Male LFABP Null Mice
Novel Hyperplastic Expansion of White Adipose Tissue Underlies the Metabolically Healthy Obese Phenotype of Male LFABP Null Mice Open
Obesity is an important risk factor for the development of metabolic syndrome disorders. We previously showed that the liver fatty acid-binding protein null mouse (LFABP−/−) becomes obese upon high-fat diet (HFD) feeding but remains metabo…
View article: Novel hyperplastic expansion of white adipose tissue underlies the metabolically healthy obese phenotype of male LFABP null mice
Novel hyperplastic expansion of white adipose tissue underlies the metabolically healthy obese phenotype of male LFABP null mice Open
Obesity is an important risk factor for the development of metabolic syndrome disorders. We previously showed that the liver fatty acid-binding protein null mouse (LFABP −/− ) becomes obese upon high-fat diet (HFD) feeding but remains meta…
View article: The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective <i>Trypanosoma brucei</i>
The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective <i>Trypanosoma brucei</i> Open
RNA-binding proteins (RBPs) are key players in coordinated post-transcriptional regulation of functionally related genes, defined as RNA regulons. RNA regulons play particularly critical roles in parasitic trypanosomes, which exhibit unreg…
View article: The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective Trypanosoma brucei
The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective Trypanosoma brucei Open
RNA-binding proteins are key players in coordinated post-transcriptional regulation of functionally related genes, defined as RNA regulons. RNA regulons play particularly critical roles in parasitic trypanosomes, which exhibit unregulated …
View article: The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective Trypanosoma brucei
The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective Trypanosoma brucei Open
RNA-binding proteins are key players in coordinated post-transcriptional regulation of functionally related genes, defined as RNA regulons. RNA regulons play particularly critical roles in parasitic trypanosomes, which exhibit unregulated …
View article: Outcomes After Percutaneous Tracheostomy in Patients with COVID-19: A Single-Center Series of 377 Cases
Outcomes After Percutaneous Tracheostomy in Patients with COVID-19: A Single-Center Series of 377 Cases Open
Introduction The COVID 19 pandemic was highlighted by a rise in hospital admissions secondary to respiratory decompensation. This was accompanied by an increase in ICU admissions, endotracheal intubation and mechanical ventilation. As a co…
View article: Comprehensive Analysis of Disease Pathology in Immunocompetent and Immunocompromised Hosts following Pulmonary SARS-CoV-2 Infection
Comprehensive Analysis of Disease Pathology in Immunocompetent and Immunocompromised Hosts following Pulmonary SARS-CoV-2 Infection Open
The Coronavirus disease 2019 (COVID-19) pandemic disproportionately affects immunocompetent and immunocompromised individuals, with the latter group being more vulnerable to severe disease and death. However, the differential pathogenesis …
View article: Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains Open
Mechanisms underlying variability in transmission of Mycobacterium tuberculosis strains remain undefined. By characterizing high and low transmission strains of M.tuberculosis in mice, we show here that high transmission M.tuberculosis str…
View article: Comprehensive analysis of disease pathology in immunocompetent and immunocompromised hamster models of SARS-CoV-2 infection
Comprehensive analysis of disease pathology in immunocompetent and immunocompromised hamster models of SARS-CoV-2 infection Open
The pathogenesis of SARS-CoV-2 in the context of a specific immunological niche is not fully understood. Here, we used a golden Syrian hamster model to systematically evaluate the kinetics of host response to SARS-CoV-2 infection, followin…
View article: The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective Trypanosoma brucei
The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective Trypanosoma brucei Open
RNA-binding proteins are key players in coordinated post-transcriptional regulation of functionally related genes, defined as RNA regulons. RNA regulons play particularly critical roles in parasitic trypanosomes, which exhibit unregulated …
View article: The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective<i>Trypanosoma brucei</i>
The RNA-binding protein RBP42 regulates cellular energy metabolism in mammalian-infective<i>Trypanosoma brucei</i> Open
RNA-binding proteins are key players in coordinated post-transcriptional regulation of functionally related genes, defined as RNA regulons. RNA regulons play particularly critical roles in parasitic trypanosomes, which exhibit unregulated …
View article: 411 Cancer cell stemness and collagen regulators of stemness in uterine serous carcinoma (USC) mirror ovarian serous cancer (OSC) cell stemness: evidence emerging from ARK1-USC
411 Cancer cell stemness and collagen regulators of stemness in uterine serous carcinoma (USC) mirror ovarian serous cancer (OSC) cell stemness: evidence emerging from ARK1-USC Open
Introduction/Background ARK1-USC, a highly annotated USC-derived cell line with a clinically relevant mutation spectrum,1 is employed in vitro and in vivo for translational studies of novel USC therapies.2 In ovarian …
View article: Analysis of 1,25-Dihydroxyvitamin D<sub>3</sub> Genomic Action Reveals Calcium-Regulating and Calcium-Independent Effects in Mouse Intestine and Human Enteroids
Analysis of 1,25-Dihydroxyvitamin D<sub>3</sub> Genomic Action Reveals Calcium-Regulating and Calcium-Independent Effects in Mouse Intestine and Human Enteroids Open
Although vitamin D is critical for the function of the intestine, most studies have focused on the duodenum. We show that transgenic expression of the vitamin D receptor (VDR) only in the distal intestine of VDR null mice (KO/TG mice) resu…
View article: Rapidly Correcting Frameshift Mutations in the Mycobacterium tuberculosis <i>orn</i> Gene Produce Reversible Ethambutol Resistance and Small-Colony-Variant Morphology
Rapidly Correcting Frameshift Mutations in the Mycobacterium tuberculosis <i>orn</i> Gene Produce Reversible Ethambutol Resistance and Small-Colony-Variant Morphology Open
We have identified a previously unknown mechanism of reversible high-level ethambutol (EMB) resistance in Mycobacterium tuberculosis that is caused by a reversible frameshift mutation in the M. tuberculosis orn gene. A frameshift mutation …
View article: A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in Cryptococcus neoformans
A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in Cryptococcus neoformans Open
Cryptococcus neoformans is the leading cause of fungal meningitis, accounting for ∼15% of HIV/AIDS-related deaths, but treatment options for cryptococcosis are limited. Echinocandins are the newest fungicidal drug class introduced but are …
View article: Phase variation in <i>Mycobacterium tuberculosis glpK</i> produces transiently heritable drug tolerance
Phase variation in <i>Mycobacterium tuberculosis glpK</i> produces transiently heritable drug tolerance Open
The length and complexity of tuberculosis (TB) therapy, as well as the propensity of Mycobacterium tuberculosis to develop drug resistance, are major barriers to global TB control efforts. M. tuberculosis is known to have the ability to en…
View article: Phase variation in<i>Mycobacterium tuberculosis glpK</i>produces transiently heritable drug tolerance
Phase variation in<i>Mycobacterium tuberculosis glpK</i>produces transiently heritable drug tolerance Open
The length and complexity of tuberculosis (TB) therapy, as well as the propensity of Mycobacterium tuberculosis to develop drug resistance, are major barriers to global TB control efforts. M. tuberculosis is known to have the ability to en…
View article: Paraspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways
Paraspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways Open
OBJECTIVES Thoracic endovascular techniques for aneurysm repair offer less invasive alternatives to open strategies. Both approaches, however, are associated with the risk for neurological complications. Despite adjuncts to maintain spinal…
View article: Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy
Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy Open
View article: Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA
Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA Open
Cell wall biosynthesis inhibitors have proven highly effective for treating tuberculosis (TB). We discovered and validated members of the indazole sulfonamide class of small molecules as inhibitors of Mycobacterium tuberculosis KasA—a key …
View article: A Novel Small-Molecule Inhibitor of the <i>Mycobacterium tuberculosis</i> Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells
A Novel Small-Molecule Inhibitor of the <i>Mycobacterium tuberculosis</i> Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells Open
Active tuberculosis (TB) and latent Mycobacterium tuberculosis infection both require lengthy treatments to achieve durable cures. This problem has partly been attributable to the existence of nonreplicating M. tuberculosis “persisters” th…