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View article: Clinical Pharmacogenetics Implementation Consortium Guideline for <i>CYP2B6</i> Genotype and Methadone Therapy
Clinical Pharmacogenetics Implementation Consortium Guideline for <i>CYP2B6</i> Genotype and Methadone Therapy Open
Methadone is a mu (μ) opioid receptor agonist used clinically in adults and children to manage opioid use disorder, neonatal abstinence syndrome, and acute and chronic pain. It is typically marketed as a racemic mixture of R ‐ and S ‐enant…
View article: Corrigendum: Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder
Corrigendum: Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder Open
There was a significant time x responder group interaction for methylation in FKBP5 intron 7 bin2 [F(1, 19) = 7.492, p = 0.013, Bonferroni adjusted p = 0.052; Figure 4 and Supplemental Table 2] whereby responders had an increase in methyla…
View article: Genome Wide Epistasis Study of On-Statin Cardiovascular Events with Iterative Feature Reduction and Selection
Genome Wide Epistasis Study of On-Statin Cardiovascular Events with Iterative Feature Reduction and Selection Open
Predicting risk for major adverse cardiovascular events (MACE) is an evidence-based practice that incorporates lifestyle, history, and other risk factors. Statins reduce risk for MACE by decreasing lipids, but it is difficult to stratify r…
View article: Genome Wide Epistasis Study of On-Statin Cardiovascular Events with Iterative Feature Reduction and Selection
Genome Wide Epistasis Study of On-Statin Cardiovascular Events with Iterative Feature Reduction and Selection Open
Background Predicting risk for major adverse cardiovascular events (MACE) is an evidence-based practice that incorporates lifestyle, history, and other risk factors. Statins reduce risk for MACE by decreasing lipids, but it is difficult to…
View article: Association of Choroid Plexus Enlargement With Cognitive, Inflammatory, and Structural Phenotypes Across the Psychosis Spectrum
Association of Choroid Plexus Enlargement With Cognitive, Inflammatory, and Structural Phenotypes Across the Psychosis Spectrum Open
These findings suggest the involvement of the choroid plexus across the psychosis spectrum with a potential pathophysiological mechanism involving the neuroimmune axis, which functions in maintaining brain homeostasis and interacting with …
View article: Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder
Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder Open
Mindfulness Based Stress Reduction (MBSR) is an effective non-pharmacologic treatment for veterans with PTSD. Extensive work has identified epigenetic factors related to PTSD disease risk and pathophysiology, but how these factors influenc…
View article: Adverse events and concurrent medications associated with parenteral nutrition use
Adverse events and concurrent medications associated with parenteral nutrition use Open
In this study, clinical manifestations of adverse events and frequently used medications in patients receiving parenteral nutrition ( PN ) in Korea were evaluated using Korea Adverse Event Reporting System ( KAERS ) database records betwee…
View article: 68. Cognitive Burden of Anticholinergic Medications in Psychotic Disorders
68. Cognitive Burden of Anticholinergic Medications in Psychotic Disorders Open
\nBackground: Patients with psychotic disorders are often treated with many medications that have anticholinergic effects, and we assessed cognitive burden of anticholinergic drug regimens in participants from the Bipolar Schizophrenia Net…
View article: Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations
Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations Open
Optimizing antipsychotic pharmacotherapy is often challenging due to significant variability in effectiveness and tolerability. Genetic factors influencing pharmacokinetics and pharmacodynamics may contribute to some of this variability. R…
View article: Discrepancy in Vancomycin AUC/MIC Ratio Targeted Attainment Based upon the Susceptibility Testing in Staphylococcus aureus
Discrepancy in Vancomycin AUC/MIC Ratio Targeted Attainment Based upon the Susceptibility Testing in Staphylococcus aureus Open
This study demonstrated a statistically significant difference in vancomycin minimum inhibitory concentration (MIC) for Staphylococcus aureus between a common automated system (Vitek 2) and the E-test method in patients with S. aureus bloo…