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View article: Morin Attenuates Diclofenac‐Induced Hepatocellular Death Injury via Nrf2/Ho‐1/NQO1, Beclin‐1/LC3A/LC3B and p53/Bax/Caspase Signalling Pathways
Morin Attenuates Diclofenac‐Induced Hepatocellular Death Injury via Nrf2/Ho‐1/NQO1, Beclin‐1/LC3A/LC3B and p53/Bax/Caspase Signalling Pathways Open
Diclofenac (DF), a nonsteroidal and anti‐inflammatory drug, has limited use due to its adverse effects on the liver. On the other hand, morin, a bioflavonoid, has biological and pharmacological properties. This study aims to investigate wh…
View article: The Protective Effects of Chrysin on Acrylamide‐Induced Hepatotoxicity: Insights Into Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histological Evaluation in Rats
The Protective Effects of Chrysin on Acrylamide‐Induced Hepatotoxicity: Insights Into Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histological Evaluation in Rats Open
Acrylamide (ACR) is a toxic chemical with a high carcinogenic risk that is released as a result of heating or processing foods at high temperatures. Chrysin (CHR) is a flavonoid that is naturally found in foods such as honey and passionflo…
View article: Neuroprotective potential of carvacrol: restoration of oxidative balance and mitigation of brain injury markers in isoproterenol-induced rats
Neuroprotective potential of carvacrol: restoration of oxidative balance and mitigation of brain injury markers in isoproterenol-induced rats Open
This research investigated the protective properties of Carvacrol (CVC) against Isoproterenol (ISO)-induced oxidative stress, neuroinflammation, and mitochondrial dysfunction in rats. The findings showed that CVC treatment did not signific…
View article: Integrative Analysis of Dog Serum‐Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis
Integrative Analysis of Dog Serum‐Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis Open
Background The tissue‐ and developmental stage‐specific expression of circular RNAs (circRNAs) makes them promising disease biomarkers. CircRNAs play a crucial role in regulating inflammatory responses; however, their function in canine pa…
View article: Effects of In-Ovo Chrysin Injection to Quail Eggs on Hatchability, Production Parameters, and Immunity
Effects of In-Ovo Chrysin Injection to Quail Eggs on Hatchability, Production Parameters, and Immunity Open
This study investigated the effects of in ovo Chrysin injection on hatchability, embryonic mortality, body weight, feed conversion ratio (FCR), and immune responses in quails. A total of 720 fertilized eggs were randomly assigned to four g…
View article: Investigation of protective effects of rutin\cyclodextrin inclusion complex against testicular damage caused by diisononyl phthalate in rats.
Investigation of protective effects of rutin\cyclodextrin inclusion complex against testicular damage caused by diisononyl phthalate in rats. Open
DINP administration induced testicular toxicity by increasing oxidative stress, apoptosis, and inflammation, and changes in testicular histology. Moreover, RUT\CD administration attenuated DINP-induced toxic effects.
View article: Cardiotoxicity caused by acrylamide in rats can be alleviated as a result of suppression of oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis by morin treatment.
Cardiotoxicity caused by acrylamide in rats can be alleviated as a result of suppression of oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis by morin treatment. Open
Taken together, morin may protect against ACR-induced cardiac injury by suppressing oxidative stress, inflammation, ERS, and apoptosis.
View article: Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways.
Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways. Open
Overall, Morin may be an effective treatment of choice for testicular tissue damage associated with Diclo toxicity and may reduce the level of damage.
View article: 18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis
18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis Open
Bisphenol A (BPA) has been commonly used in various consumer products, including water bottles, food containers, and canned food linings. However, there are concerns about its potential toxicity to human health, particularly its impact on …
View article: Research on Hematology, Inflammatory and Antimicrobial Peptide Levels according to Clinical Scoring in Calves with Bovine Respiratory Disease (BRD)
Research on Hematology, Inflammatory and Antimicrobial Peptide Levels according to Clinical Scoring in Calves with Bovine Respiratory Disease (BRD) Open
Bovine respiratory disease (BRD) is a significant and costly disease in cattle, characterized by various infections with distinct causes and clinical signs. This study focuses on investigating some hematological and inflammatory parameters…
View article: Investigation of the Effects of Rutin in Spraque Dawley Rats with Biochemical Parameters in Colistin-Induced Lung Injury
Investigation of the Effects of Rutin in Spraque Dawley Rats with Biochemical Parameters in Colistin-Induced Lung Injury Open
Colistin (COL), frequently used for Gram-negative bacteria, may cause pulmonary toxicity in a dose-dependent manner. Flavanoid-type antioxidants have started to be used frequently against toxicity caused by different chemical agents. Rutin…
View article: Investigation of the effects of apilarnil and imatinib use on liver and kidney tissues in rats via PI3K/AKT/mTOR and JAK2/STAT3 pathways
Investigation of the effects of apilarnil and imatinib use on liver and kidney tissues in rats via PI3K/AKT/mTOR and JAK2/STAT3 pathways Open
Imatinib, used in the field of molecular targeted therapy, has been reported to cause serious side effects, including liver and kidney failure. However, the mechanism of imatinib-induced liver and kidney toxicity remains unclear due to lim…
View article: The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 pathways
The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 pathways Open
Arsenic is a toxic environmental pollutant heavy metal, and one of its critical target tissues in the body is the liver. Carvacrol is a natural phytocompound that stands out with its antioxidant, anti‐inflammatory, and antiapoptotic proper…
View article: Protective Effects of Carvacrol on Mercuric Chloride‐Induced Lung Toxicity Through Modulating Oxidative Stress, Apoptosis, Inflammation, and Autophagy
Protective Effects of Carvacrol on Mercuric Chloride‐Induced Lung Toxicity Through Modulating Oxidative Stress, Apoptosis, Inflammation, and Autophagy Open
Mercuric chloride (HgCl 2 ) is extremely toxic to both humans and animals. It could be absorbed via ingestion, inhalation, and skin contact. Exposure to HgCl 2 can cause severe health effects, including damages to the gastrointestinal, res…
View article: Protective Effects of Syringic Acid Against Oxidative Damage, Apoptosis, Autophagy, Inflammation, Testicular Histopathologic Disorders, and Impaired Sperm Quality in the Testicular Tissue of Rats Induced by Mercuric Chloride
Protective Effects of Syringic Acid Against Oxidative Damage, Apoptosis, Autophagy, Inflammation, Testicular Histopathologic Disorders, and Impaired Sperm Quality in the Testicular Tissue of Rats Induced by Mercuric Chloride Open
Mercury (Hg) is one of the most toxic heavy metals that damage testicular tissue. Mercury chloride (HgCl 2 ) is one of the most toxic forms of mercury that can easily cross biological membranes. Syringic acid (SA) is a natural flavonoid fo…
View article: Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways
Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways Open
Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural flavonoid found in plants, and its antioxidant p…
View article: EFFECTS OF Ehrlichia canis, Anaplasma phagocytophilum /Anaplasma platys AND Dirofilaria immitis INFECTIONS ON OXIDATIVE STRESS AND ANTIOXIDANT BALANCE IN DOGS
EFFECTS OF Ehrlichia canis, Anaplasma phagocytophilum /Anaplasma platys AND Dirofilaria immitis INFECTIONS ON OXIDATIVE STRESS AND ANTIOXIDANT BALANCE IN DOGS Open
The aim of the study was to investigate changes in serum oxidant/antioxidant balance in dogs of different breeds and sex, which were infected with Ehrlichia, Anaplasma or Dirofilaria immitis. We also sought to analyze the impact of pathoge…
View article: Sinapic acid protects against lead acetate‐induced lung toxicity by reducing oxidative stress, apoptosis, inflammation, and endoplasmic reticulum stress damage
Sinapic acid protects against lead acetate‐induced lung toxicity by reducing oxidative stress, apoptosis, inflammation, and endoplasmic reticulum stress damage Open
Lead acetate (PbAc) is a compound that produces toxicity in many tissues after exposure. Sinapic acid (SNP) possesses many biological and pharmacological properties. This study aimed to investigate the efficacy of SNP on the toxicity of Pb…
View article: Effects of zingerone on rat induced testicular toxicity by sodium arsenite via oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, and autophagy pathways.
Effects of zingerone on rat induced testicular toxicity by sodium arsenite via oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, and autophagy pathways. Open
ZNG treatment reduced SA-induced oxidative stress, ER stress, inflammation, apoptosis, and histological irregularities in the testicles while increasing sperm quality. As a result, it was observed that ZNG could alleviate the toxicity caus…
View article: Zingerone attenuates sciatic nerve damage caused by sodium arsenite by inhibiting NF-κB, caspase-3, and ATF-6/CHOP pathways and activating the Akt2/FOXO1 pathway.
Zingerone attenuates sciatic nerve damage caused by sodium arsenite by inhibiting NF-κB, caspase-3, and ATF-6/CHOP pathways and activating the Akt2/FOXO1 pathway. Open
In general, SA caused oxidative stress, inflammation, ER stress, and apoptosis in the sciatic nerves of rats, causing damage to the tissues, however, ZNG suppressed these pathways and protected the sciatic nerves from the destructive effec…
View article: Naringin is Protective in Paclitaxel-Induced Peripheral Neuropathy; A Multi-Biomarker Approach
Naringin is Protective in Paclitaxel-Induced Peripheral Neuropathy; A Multi-Biomarker Approach Open
Aim: Cancer is a disease that is on the rise worldwide. Paclitaxel (PTX) is one of the most common chemotherapeutic agents used in the treatment of many cancers. PTX causes toxic effects by increasing oxidative stress in tissues. Naringin …
View article: Naringin Protects Against Colistin-Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage
Naringin Protects Against Colistin-Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage Open
Colistin is used in treatment against gram-negative bacteria. It causes toxic effects due to oxidative stress in a dose-dependent manner. Naringin is a flavonoid with strong antioxidant properties found naturally in many plants, especially…
View article: Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue
Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue Open
In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular tissue of rats was tried to be determined. PbAc was adminis…
View article: Investigation of haematological, inflammatory and immunological response in naturally infected cattle with <i>Theileria annulata</i>
Investigation of haematological, inflammatory and immunological response in naturally infected cattle with <i>Theileria annulata</i> Open
In this study, we aimed to investigate haematological, pro‐inflammatory, inflammatory, anti‐inflammatory and immunological responses in naturally Theileria annulata‐ infected cattle. The study material consisted of 25 Simmental cattle, 2–4…
View article: Beneficial effects of quercetin on vincristine‐induced liver injury in rats: Modulating the levels of Nrf2/HO‐1, NF‐kB/STAT3, and SIRT1/PGC‐1α
Beneficial effects of quercetin on vincristine‐induced liver injury in rats: Modulating the levels of Nrf2/HO‐1, NF‐kB/STAT3, and SIRT1/PGC‐1α Open
Our experimental objective was to investigate the hepatotoxic effect of vincristine (VCR) administration in rats and determined whether combined therapy with Quercetin (Quer) ensured protection. Five groups with seven rats each were used f…
View article: Oxidative stress parameters in dogs naturally infected with sarcoptic mange
Oxidative stress parameters in dogs naturally infected with sarcoptic mange Open
Background: Scabies is one of the most common diseases in dogs. It threatens both animals and humans due to its zoonotic potential. Objective: The purpose of this study was to evaluate the oxidant/antioxidant balance with hematological fin…
View article: Morin provides therapeutic effect by attenuating oxidative stress, inflammation, endoplasmic reticulum stress, autophagy, apoptosis, and oxidative DNA damage in testicular toxicity caused by ifosfamide in rats.
Morin provides therapeutic effect by attenuating oxidative stress, inflammation, endoplasmic reticulum stress, autophagy, apoptosis, and oxidative DNA damage in testicular toxicity caused by ifosfamide in rats. Open
As a result, it was observed that IFOS caused cellular damage by activating various signaling pathways in testicular tissue, while morin exhibited protective properties against this damage.
View article: Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach.
Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach. Open
Evaluating all data showed that SA caused toxic damage to lung tissue by increasing inflammation, apoptosis, autophagy, and oxidant levels, whereas ZNG had a protective effect by reducing this damage.
View article: Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways Open
Background Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side…