Sei Harada
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View article: Longitudinal study of plasma metabolites during menopause and their associations with later onset of metabolic syndrome
Longitudinal study of plasma metabolites during menopause and their associations with later onset of metabolic syndrome Open
Context Previous metabolomics studies suggest potential associations between menopausal changes in lipids and an increased risk of metabolic syndrome (MetS). However, longitudinal data on other key metabolites, such as branched-chain amino…
View article: Causal relationship between body mass index and insulin resistance: Linear and nonlinear Mendelian randomization study in a Japanese population
Causal relationship between body mass index and insulin resistance: Linear and nonlinear Mendelian randomization study in a Japanese population Open
Aims/Introduction Obesity is a known risk factor for several chronic diseases, including type 2 diabetes mellitus, which results from increased insulin resistance and impaired insulin secretion. However, the association between obesity and…
View article: Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits
Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits Open
Plasma amino acids (AAs) have emerged as promising biomarkers for metabolic disorders, yet their causality remains unclear. We aimed to investigate the genetic determinants of AA levels in a cohort of 10,333 individuals and their causal ef…
View article: Evaluation of Medication Adherence Among Prevalent Users in Hypertension, Dyslipidemia, and Diabetes Using Health Insurance Claims: A Population‐Based Cohort Study in Japan
Evaluation of Medication Adherence Among Prevalent Users in Hypertension, Dyslipidemia, and Diabetes Using Health Insurance Claims: A Population‐Based Cohort Study in Japan Open
Purpose Hypertension (HT), dyslipidemia (DL), and diabetes mellitus (DM) are major risk factors for cardiovascular diseases. Despite the wide availability of medications to reduce this risk, poor adherence to medications remains an issue. …
View article: Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers
Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers Open
NAFLD was associated with a marker of atherosclerosis, and several metabolites related to insulin resistance, including BCAAs and AAAs, could be involved in the process by which NAFLD leads to atherosclerosis.
View article: Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study
Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study Open
Studies examining long-term longitudinal metabolomic data and their reliability in large-scale populations are limited. Therefore, we aimed to evaluate the reliability of repeated measurements of plasma metabolites in a prospective cohort …
View article: Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS)
Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS) Open
The Tsuruoka Metabolomics Cohort Study (TMCS) is an ongoing population-based cohort study being conducted in the rural area of Yamagata Prefecture, Japan. This study aimed to enhance the precision prevention of multi-factorial, complex dis…
View article: A population-based urinary and plasma metabolomics study of environmental exposure to cadmium
A population-based urinary and plasma metabolomics study of environmental exposure to cadmium Open
These results suggested that U-Cd was associated with metabolites related to upstream mitochondrial dysfunction in a dose-dependent manner. Our data will help develop environmental Cd exposure profiles for human populations.
View article: Quality Control of Targeted Plasma Lipids in a Large-Scale Cohort Study Using Liquid Chromatography–Tandem Mass Spectrometry
Quality Control of Targeted Plasma Lipids in a Large-Scale Cohort Study Using Liquid Chromatography–Tandem Mass Spectrometry Open
High-throughput metabolomics has enabled the development of large-scale cohort studies. Long-term studies require multiple batch-based measurements, which require sophisticated quality control (QC) to eliminate unexpected bias to obtain bi…
View article: The association between sleep parameters and sarcopenia in Japanese community-dwelling older adults
The association between sleep parameters and sarcopenia in Japanese community-dwelling older adults Open
Long sleep was associated with sarcopenia, including LMS and LPP. However, in long sleepers, insomnia was not associated with sarcopenia or any of its components.
View article: Accumulated unhealthy behaviours and insomnia in Japanese dwellers with and without cardiovascular risk factors: a cross-sectional study
Accumulated unhealthy behaviours and insomnia in Japanese dwellers with and without cardiovascular risk factors: a cross-sectional study Open
Objectives To date, the association between accumulated unhealthy behaviours and insomnia in individuals stratified according to the presence or absence of major cardiovascular risk factors is unclear. This study aimed to examine the effec…
View article: Dietary Patterns and Their Associations with Intermediate Age-Related Macular Degeneration in a Japanese Population
Dietary Patterns and Their Associations with Intermediate Age-Related Macular Degeneration in a Japanese Population Open
This population-based cross-sectional study investigated the influence of dietary patterns on age-related macular degeneration (AMD) in a Japanese population. The Tsuruoka Metabolomics Cohort Study enrolled a general population aged 35–74 …
View article: Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol
Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol Open
Introduction The rapid spread of COVID-19 posed a global burden. Substantial number of people died of the disease in the acute phase of infection. In addition, a significant proportion of patients have been reported to suffer from post-acu…
View article: Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study
Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study Open
Multiple charged metabolites were associated with women's menopausal status, showing a gradual increase as women shifted from pre-, to peri-, to postmenopause. These findings might reflect the early changes behind the increased risk of dys…
View article: 697Change of smoking habits by introducing and spreading heated tobacco products in Japan
697Change of smoking habits by introducing and spreading heated tobacco products in Japan Open
Background Heated tobacco product (HTP) users are rapidly increasing in Japan since 2014. Controlling HTPs is now one of the most urgent issues. We aimed to clarify the change of smoking habits by introducing and spreading HTPs. Methods We…
View article: 1299Association between environmental cadmium exposure and plasma and urinary metabolite profiles in Japanese cohort study
1299Association between environmental cadmium exposure and plasma and urinary metabolite profiles in Japanese cohort study Open
Background The purpose of this study was to identify plasma and urinary metabolites that can be used to better identify the effects of cadmium exposure than N-acetyl-β-D-glucosaminidase (NAG) using capillary electrophoresis - mass spectrom…
View article: Erratum to “Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims” [J Epidemiol 31 (9) (2021) 495–502]
Erratum to “Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims” [J Epidemiol 31 (9) (2021) 495–502] Open
1 some of the generic names and their Anatomical Therapeutic Chemical (ATC) codes were incorrectly stated in eTable 1, eTable 2, and eTable 3. Some of the generic names and their ATC codes have been added or deleted.Additionally, some of t…
View article: SARS-CoV-2 Infection among Medical Institution Faculty and Healthcare Workers in Tokyo, Japan
SARS-CoV-2 Infection among Medical Institution Faculty and Healthcare Workers in Tokyo, Japan Open
Objective To consider effective measures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in medical institutions, this study estimated the SARS-CoV-2 infection rate among healthcare workers (HCWs) in Tokyo, J…
View article: 320 Effect of accumulated unhealthy behaviors on insomnia―lifestyle-related disease differences in a Japanese community population
320 Effect of accumulated unhealthy behaviors on insomnia―lifestyle-related disease differences in a Japanese community population Open
Introduction Some studies reported that health behaviors and lifestyles are related to sleep disorder; obesity, drinking, smoking and lack of physical exercise are risk factors for insomnia. However, it’s unclear the association between ac…
View article: Correction: Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan
Correction: Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan Open
[This corrects the article DOI: 10.1371/journal.pone.0246456.].
View article: Association of the Estimated Coronary Artery Incidence Risk According to the Japan Atherosclerosis Society Guidelines 2017 with Cardio-Ankle Vascular Index
Association of the Estimated Coronary Artery Incidence Risk According to the Japan Atherosclerosis Society Guidelines 2017 with Cardio-Ankle Vascular Index Open
The risk stratification, which was proposed in the JAS Guidelines 2017, is concordant with the arterial stiffness parameter.
View article: Reproducibility and validity of food group intake in a short food frequency questionnaire for the middle-aged Japanese population
Reproducibility and validity of food group intake in a short food frequency questionnaire for the middle-aged Japanese population Open
Purpose The purpose of this study was to evaluate the reproducibility and validity of a short food frequency questionnaire (FFQ) for food group intake in Japan, the reproducibility and partial validity of which were previously confirmed fo…
View article: Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan
Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan Open
Food intake biomarkers can be critical tools that can be used to objectively assess dietary exposure for both epidemiological and clinical nutrition studies. While an accurate estimation of food intake is essential to unravel associations …
View article: Additional file 2 of Reproducibility and validity of food group intake in a short food frequency questionnaire for the middle-aged Japanese population
Additional file 2 of Reproducibility and validity of food group intake in a short food frequency questionnaire for the middle-aged Japanese population Open
Additional file 2. Spearman's rank correlation coefficients of energy-adjusted intakes (density method) for reproducibility and validity for men and women.