Sei Kakinuma
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View article: Crosstalk via ICAM-1 enhances supportive phenotype of stellate cells and drives hepatocyte proliferation in iPSC-derived hepatic organoids
Crosstalk via ICAM-1 enhances supportive phenotype of stellate cells and drives hepatocyte proliferation in iPSC-derived hepatic organoids Open
The interaction between hepatic stellate cells (HSCs) and hepatocytes contributes to HSC activation and liver regeneration; however, the mechanisms in humans remain unclear, particularly the significance of their direct contact and the rol…
View article: Effect of Immunotherapy on Late Elderly Patients With Unresectable Hepatocellular Carcinoma: A Real‐World Clinical Study
Effect of Immunotherapy on Late Elderly Patients With Unresectable Hepatocellular Carcinoma: A Real‐World Clinical Study Open
Background/Aim The global aging population includes an increasing number of elderly patients with hepatocellular carcinoma (HCC). This study aimed to clarify the real‐world outcomes, prognostic factors, and appropriate administration indic…
View article: Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids
Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids Open
Human induced pluripotent stem cells (iPSCs) can be differentiated into hepatocyte-like cells (iPS-Heps); however, maintaining the long-term proliferation and hepatic characteristics of iPS-Heps remains a challenge. In this study, we aimed…
View article: A Case of Congenital Midline Upper Lip Fistula
A Case of Congenital Midline Upper Lip Fistula Open
Herein, we describe the case of a 33-year-old woman with a rare 16-mm congenital midline upper lip fistula with a broad, cystic lumen. No connection with the oral cavity was observed. Congenital midline upper lip fistulas are not clearly a…
View article: Analysis of prognosis and background liver disease in non-advanced hepatocellular carcinoma in two decades
Analysis of prognosis and background liver disease in non-advanced hepatocellular carcinoma in two decades Open
Background/Aim Antiviral hepatitis and systemic therapies for hepatocellular carcinoma (HCC) remarkably progressed in the recent 10 years. This study aimed to reveal the actual transition and changes in the prognosis and background liver d…
View article: Prognostic significance of C‐reactive protein in unresectable hepatocellular carcinoma treated with atezolizumab and bevacizumab
Prognostic significance of C‐reactive protein in unresectable hepatocellular carcinoma treated with atezolizumab and bevacizumab Open
Aim C‐reactive protein (CRP) is both an inflammatory and prognostic marker in various cancers. This study aimed to elucidate the characteristics of CRP and the prognostic factors in patients who were administered with atezolizumab plus bev…
View article: Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids
Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids Open
Human intestinal organoids (HIOs) derived from human pluripotent stem cells (hPSCs) hold great promise for translational medical applications. A common method to obtain HIOs has been to harvest floating hindgut spheroids arising from hPSCs…
View article: Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts
Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts Open
Formation of intrahepatic bile ducts (IHBDs) proceeds in accordance with their microenvironment. Particularly, mesenchymal cells around portal veins regulate the differentiation and ductular morphogenesis of cholangiocytes in the developin…
View article: Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma‐like area and metachronous hepatocellular carcinoma
Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma‐like area and metachronous hepatocellular carcinoma Open
Aim The genetic profile of cholangiolocellular carcinoma (CLC) and its origin in relation to hepatocellular carcinoma (HCC) remain unclear. To elucidate the genetic profile of CLC, a comprehensive analysis of genetic mutations was carried …
View article: Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients
Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients Open
Resistance-associated substitutions (RASs) of hepatitis C virus (HCV) in the NS5A region impair the efficacy of NS5A inhibitors. In this study, we evaluated the characteristics of the novel RASs observed in treatment-failure patients, A92K…
View article: Analysis of the mechanism underlying liver diseases using human induced pluripotent stem cells
Analysis of the mechanism underlying liver diseases using human induced pluripotent stem cells Open
Results of recent studies have shown that disease models using human induced pluripotent stem (iPS) cells have recapitulated the pathophysiology of genetic liver diseases, viral hepatitis and hepatic fibrosis. The utilization of human iPS …
View article: LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells
LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells Open
Human induced pluripotent stem (iPS) cells can differentiate into hepatocyte lineages, although the phenotype of the differentiated cells is immature compared to adult hepatocytes. Improvement of cell-cell interactions between epithelium a…
View article: Supplementary Material for: Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease
Supplementary Material for: Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease Open
Background: The risk factors associated with the development of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease (NAFLD) are still unclear. The aim of the present study was to identify such risk factors in NAFLD patients …
View article: Evaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System
Evaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System Open
A novel genotype 1b HCV cell culture was constructed with core amino acid substitutions, which demonstrated IFN resistance of genotype 1b. This system will be useful for future analyses into the mechanisms of HCV genotype 1b treatment.
View article: A case of hepatitis C virus-associated mixed cryoglobulinemia treated with direct-acting antivirals
A case of hepatitis C virus-associated mixed cryoglobulinemia treated with direct-acting antivirals Open
症例は79歳女性．25年前にC型慢性肝炎と診断され，その後クリオグロブリン関連腎症と診断された．C型肝炎ウイルス（HCV）排除とクリオグロブリン血症の改善のために様々なInterferon（IFN）-based therapyを行ったものの無効であった．今回，蛋白尿と腎機能の急性増悪から致死的な心不全を併発して入院した．体液コントロールとクリオグロブリン除去による蛋白尿改善を目的に血漿交換/血液透析併用療法を開始し，心不全と体液貯留が改善した後，daclatasvir/as…
View article: A case of primary sclerosing cholangitis with unique clinical features for a 5-year follow up
A case of primary sclerosing cholangitis with unique clinical features for a 5-year follow up Open
症例は26歳女性．2008年（21歳時）健康診断で肝機能障害を指摘され当科紹介受診となった．各種ウイルスおよび自己抗体は陰性で，BMI 25.1（152 cm/58 kg）と軽度肥満と，美容のためにビタミン剤などのサプリメント摂取歴を認めたことから食事運動療法および摂取サプリメントを中止し経過観察となったが，生活習慣の指導，肝庇護療法を開始した後もトランスアミナーゼは高値のまま推移した．2010年，2012年に施行した肝生検では確定診断には至らず，その後それまで限局性だった…
View article: Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy
Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy Open
Recent case reports have shown that hepatitis E virus (HEV) infection can cause chronic hepatitis in immunosuppressed or immunocompromised patients. A 37-year-old woman suffered from prolonged elevation of aminotransferases after chemother…