Sei Won Kim
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Utility of the BioFire® FilmArray® Pneumonia Panel Using Bronchial Washing Specimens: A Comparative Study with Conventional Culture Open
Background: Accurate identification of pneumonia pathogens is critical for guiding appropriate antibiotic therapy and minimizing unnecessary antimicrobial exposure. Bronchoalveolar lavage (BAL) is widely used for pathogen detection but int…
View article: The Korean Obstructive Sleep Apnea Morbidity Study (KOSMOS) Protocol
The Korean Obstructive Sleep Apnea Morbidity Study (KOSMOS) Protocol Open
Obstructive sleep apnea (OSA) is a heterogeneous syndrome with various predisposing factors, pathophysiological mechanisms, clinical presentations, and consequences of respiratory events. Treatment compliance and outcomes vary among the cl…
Clinical frailty scale at ICU discharge predicts ICU readmission and post-ICU mortality: A retrospective single-center study Open
Despite successful discharge from the intensive care unit (ICU), a substantial number of patients remain at risk of ICU readmission or death. Identifying high-risk individuals at the time of ICU discharge is essential for planning post-ICU…
Home High-Flow Nasal Cannula in Patients with Chronic Respiratory Failure: A Literature Review and Suggestions for Clinical Practice Open
High-flow nasal cannula (HFNC) is a noninvasive respiratory support system that delivers air that is heated at 31°C−38°C, humidified 100%, and oxygen-enriched at a constant high flow rate of 15−60 L/min. Because of its numerous physiologic…
Difference in Lymphocyte Subset Counts According to Disease Severity and SARS-CoV-2 Variants of Hospitalized COVID-19 Patients in Korea Open
The peripheral lymphocyte subset counts decreased according to disease severity and the types of SARS-CoV-2 variants in hospitalized COVID-19 patients. Despite the efficient operation of the national quarantine system and high vaccination …
Impact of lipopolysaccharide-induced acute lung injury in aged mice Open
Study Aim: As the geriatric population rapidly expands, there has been a concurrent increase in elderly admissions to intensive care units (ICUs). Acute lung injury (ALI) is a prevalent reason for these admissions and carries poorer surviv…
Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model Open
Background/Aims: Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In this stud…
Monocyte distribution width (MDW) as a useful indicator for early screening of sepsis and discriminating false positive blood cultures Open
Background Severe sepsis and septic shock are the leading cause of in-hospital death. As sepsis progresses, expression and activity of endogenous mediators of inflammation change. Early detection of biomarkers can play a role in sepsis scr…
Simple Saliva Sample Collection for the Detection of SARS-CoV-2 Variants Compared With Nasopharyngeal Swab Sample Open
Context.— The use of saliva samples for diagnosis of SARS-CoV-2 infection offers several advantages, including ease of sample collection, feasibility of self-collection, and minimization of medical staff exposure to infection. The emergenc…
Usefulness of monocyte distribution width and presepsin for early assessment of disease severity in COVID-19 patients Open
Early predictors of severe coronavirus disease 2019 (COVID-19) would identify patients requiring intensive care. Recently, the monocyte distribution width (MDW) and presepsin level have been used for the early diagnosis of sepsis. Here, we…
Impacts of the COVID-19 pandemic on sleep center operations and sleep apnea treatment in Korea Open
The coronavirus disease-2019 (COVID-19) pandemic has not only changed the lives of people around the world but also affected all areas of the healthcare system, including sleep medicine. However, no studies in Korea have investigated the s…
KL-6 in Obstructive Sleep Apnea: A Potential Biomarker of Subclinical Lung Injury Open
Objective The relationship between obstructive sleep apnea (OSA) and cardiovascular diseases has been reported in several studies. However, little is known about the effects of OSA on pathophysiological processes in the lung. This study ex…
Erratum to “Utilization of pain and sedation therapy on noninvasive mechanical ventilation in Korean intensive care units: a multi-center prospective observational study” Open
This corrects the article "Utilization of pain and sedation therapy on noninvasive mechanical ventilation in Korean intensive care units: a multi-center prospective observational study" in volume 35 on page 255.
Serial Screening for SARS-CoV-2 in Rectal Swabs of Symptomatic COVID-19 Patients Open
We used serial rectal swabs to investigate the amount and duration of virus secretion through the gastrointestinal tract and assessed the association between fecal shedding and gastrointestinal symptoms and to clarify the clinical usefulne…
Association between Atherogenic Index of Plasma and the Risk of Obstructive Sleep Apnea in Korean Adults Who Admitted to the Sleep Clinic Open
Objective Atherogenic index of plasma (AIP) is closely related to insulin resistance, which is a major characteristics of obstructive sleep apnea (OSA). However, data on the association between AIP and OSA has been limited. This study eval…
Utilization of pain and sedation therapy on noninvasive mechanical ventilation in Korean intensive care units: a multi-center prospective observational study Open
In NIV patients, analgosedation therapy may have no harmful effects on complications, NIV weaning success, and mortality compared to the control group. Therefore, sedation during NIV may not be unsafe and can be used in patients for pain c…
The Effects of Chronic Intermittent Hypoxia in Bleomycin-Induced Lung Injury on Pulmonary Fibrosis via Regulating the NF-κB/Nrf2 Signaling Pathway Open
CIH accelerated lung fibrosis in BLE-induced lung injury in mice, potentially by regulating the NF-κB/Nrf2 signaling pathway. Our results implicate PF as a potential therapeutic agent for treating pulmonary fibrosis in individuals with OSA…
Containment of a healthcare-associated COVID-19 outbreak in a university hospital in Seoul, Korea: A single-center experience Open
The robust control of the COVID-19 outbreak further minimized the transmission of SARS-CoV-2 in the hospital and local communities. However, there was also a debate over the appropriate period of hospital shutdown and testing of all hospit…
Association between triglyceride glucose index and obstructive sleep apnea risk in Korean adults: a cross-sectional cohort study Open
Background Triglyceride glucose (TyG) index is a reliable marker of insulin resistance, which is linked to obstructive sleep apnea (OSA). However, the relationship between TyG index and OSA has not been adequately assessed. This study aime…
Non-invasive ventilation for acute respiratory failure: pressure support ventilation vs. pressure-controlled ventilation Open
In contrast to PCV mode, PSV mode was significantly associated with NIV success in the intensive care unit setting, particularly when large leaks were not a major concern. Nevertheless, further well-designed multicenter, protocol-driven ra…
Role of hyperoxic treatment in cancer Open
The occurrence of hypoxia is common in many solid tumors, and it enhances aggressive features of cancer such as cell survival, angiogenesis, and metastasis while minimizing the efficacies of chemotherapy and radiotherapy. Hypoxia also play…
Utilization of a rapid response team and associated outcomes in patients with malignancy Open
Cancer patients requiring RRT activation have significantly higher rates of inhospital mortality than patients not using RRT. Higher severity score at the time of RRT activation in patients with malignancy was significantly associated with…
Intermittent hypoxia exacerbates tumor progression in a mouse model of lung cancer Open
The purpose of this study was to evaluate whether obstructive sleep apnea (OSA)-related chronic intermittent hypoxia (CIH) influences lung cancer progression and to elucidate the associated mechanisms in a mouse model of lung cancer. C57/B…
Pulmonary Function and Effects of Body Position in Patients with Obstructive Sleep Apnea Open
Objective Obstructive sleep apnea (OSA) is known to be associated with upper airway collapse during sleep. However, OSA has also been suggested to have effects on the lower airway. This study examined the association between pulmonary func…
Current Status of Noninvasive Ventilation Use in Korean Intensive Care Units: A Prospective Multicenter Observational Study Open
AHRF and post-extubation respiratory failure were the most common indications for NIV in Korean ICUs. Overall NIV success was achieved in 68.5% of patients, with the lowest rate in patients with de novo respiratory failure.