Selim Chaib
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View article: Senotherapeutics for metabolic disease and diabetic complications
Senotherapeutics for metabolic disease and diabetic complications Open
Metabolic diseases, including obesity, Type 2 diabetes (T2D), and metabolic syndrome, are increasingly prevalent worldwide, driven by sedentary lifestyles, aging populations, and complex genetic and environmental factors. Traditionally und…
View article: The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits
The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits Open
Aging disrupts physiological homeostasis, impairing thermoregulation, metabolism, and water balance, but the underlying neural mechanisms remain unclear. Here, we identify arginine vasopressin (AVP) neurons in the supraoptic nucleus (SON) …
View article: Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers
Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers Open
The senescent cell (SC) fate is linked to aging, multiple disorders and diseases, and physical dysfunction. Senolytics, agents that selectively eliminate 30-70% of SCs, act by transiently disabling the senescent cell anti-apoptotic pathway…
View article: Senescent cell transplantation into the skin induces age‐related peripheral dysfunction and cognitive decline
Senescent cell transplantation into the skin induces age‐related peripheral dysfunction and cognitive decline Open
Cellular senescence is an established cause of cell and tissue aging. Senescent cells have been shown to increase in multiple organs during aging, including the skin. Here we hypothesized that senescent cells residing in the skin can sprea…
View article: Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden
Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden Open
In the last decade cellular senescence, a hallmark of aging, has come into focus for pharmacologically targeting aging processes. Senolytics are one of these interventive strategies that have advanced into clinical trials, creating an unme…
View article: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2 Open
Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the immune checkpoint…
View article: Figure S5 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Figure S5 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 54K, Figure S5 shows blood glucose levels in mice after metformin treatment
View article: Figure S4 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Figure S4 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 92K, Figure S4 shows the effect of metformin on bRFR in the matched cohort of 172 prostate cancer patients
View article: Figure S4 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Figure S4 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 92K, Figure S4 shows the effect of metformin on bRFR in the matched cohort of 172 prostate cancer patients
View article: Figure S1 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Figure S1 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 209K, Figure S1 illustrates the method for IHC analysis. It also shows a reduction in hypoxic fraction after metformin exposure in POP-92S and LNCaP xenografts
View article: Figure S3 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Figure S3 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 77K, Figure S3 shows propensity score distribution in the unmatched and matched patient cohort
View article: Data from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Data from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
Purpose: Tumor hypoxia is a negative prognostic factor in multiple cancers, due in part to its role in causing resistance to radiotherapy. Hypoxia arises in tumor regions distal to blood vessels as oxygen is consumed by more proximal tumor…
View article: Supplementary Legends from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Supplementary Legends from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 81K, Supplementary Legends
View article: Figure S5 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Figure S5 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 54K, Figure S5 shows blood glucose levels in mice after metformin treatment
View article: Figure S3 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Figure S3 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 77K, Figure S3 shows propensity score distribution in the unmatched and matched patient cohort
View article: Supplementary Table S1 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Supplementary Table S1 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 97K, Table S1 shows the clinical demographics of the patient cohort treated with radiotherapy for prostate cancer
View article: Figure S1 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Figure S1 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 209K, Figure S1 illustrates the method for IHC analysis. It also shows a reduction in hypoxic fraction after metformin exposure in POP-92S and LNCaP xenografts
View article: Figure S2 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Figure S2 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 80K, Figure S2 shows data from in vitro and ex vivo clonogenic assays of metformin treatment in combination with radiation
View article: Figure S2 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Figure S2 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 80K, Figure S2 shows data from in vitro and ex vivo clonogenic assays of metformin treatment in combination with radiation
View article: Supplementary Table S1 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Supplementary Table S1 from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 97K, Table S1 shows the clinical demographics of the patient cohort treated with radiotherapy for prostate cancer
View article: Data from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Data from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
Purpose: Tumor hypoxia is a negative prognostic factor in multiple cancers, due in part to its role in causing resistance to radiotherapy. Hypoxia arises in tumor regions distal to blood vessels as oxygen is consumed by more proximal tumor…
View article: Supplementary Legends from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Supplementary Legends from Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response Open
PDF file 81K, Supplementary Legends
View article: The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2
The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2 Open
Anti-cancer therapies often result in a subset of surviving cancer cells that undergo therapy-induced senescence (TIS). Senescent cancer cells strongly modify the intratumoural microenvironment favoring immunosuppression and, thereby, tumo…
View article: Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype
Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype Open
Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases through their secretome, known as senesce…
View article: Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex
Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex Open
The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a ke…
View article: Role for Merlin/NF2 in transcription elongation through interaction with the PAF complex
Role for Merlin/NF2 in transcription elongation through interaction with the PAF complex Open
SUMMARY The PAF complex (PAFC) coordinates transcription elongation and mRNA processing events and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions at the cell cortex and nucleus a…