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View article: The Levels of Oxidized Phospholipids in High-Density Lipoprotein During the Course of Sepsis and Their Prognostic Value
The Levels of Oxidized Phospholipids in High-Density Lipoprotein During the Course of Sepsis and Their Prognostic Value Open
Purpose To examine the levels of 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero phosphatidylcholine (POVPC) and 1-palmitoyl-2-glutaroyl-sn-glycero-phosphatidylcholine (PGPC) (the oxidized phosphatidylcholines) in HDL during the course of sepsis …
View article: Changes in diaphragm contractility in cigarette smoking–exposed and smoking cessation rats are associated with alterations in mitochondrial morphology and homeostasis
Changes in diaphragm contractility in cigarette smoking–exposed and smoking cessation rats are associated with alterations in mitochondrial morphology and homeostasis Open
Background: Cigarette smoking (CS) is one of the greatest risk factors for the pathogenesis and progression of chronic obstructive pulmonary disease (COPD). Although CS cessation is beneficial in preventing COPD progression, the effects of…
View article: <p>Functional, Ultrastructural, and Transcriptomic Changes in Rat Diaphragms with Different Durations of Cigarette Smoke Exposure</p>
Functional, Ultrastructural, and Transcriptomic Changes in Rat Diaphragms with Different Durations of Cigarette Smoke Exposure Open
These observations suggested a transition of diaphragm muscle from initial compensatory to decompensatory changes in function, structure, and gene expression during the development of COPD.
View article: The HDL from septic-ARDS patients with composition changes exacerbates pulmonary endothelial dysfunction and acute lung injury induced by cecal ligation and puncture (CLP) in mice
The HDL from septic-ARDS patients with composition changes exacerbates pulmonary endothelial dysfunction and acute lung injury induced by cecal ligation and puncture (CLP) in mice Open
Background: Septic-acute respiratory distress syndrome (ARDS), characterized by the acute lung injury (ALI) secondary to aberrant systemic inflammatory response, has high morbidity and mortality. Despite increased understanding of ALI path…
View article: The adverse alterations of HDL in quality promote septic ARDS via exacerbated pulmonary endothelial dysfunction
The adverse alterations of HDL in quality promote septic ARDS via exacerbated pulmonary endothelial dysfunction Open
Background Septic acute respiratory distress syndrome (ARDS), characterized by the acute lung injury (ALI) secondary to aberrant systemic inflammatory response, has high morbidity and mortality. Despite increased understanding of ALI patho…
View article: Maintenance of spontaneous breathing at an intensity of 60%–80% may effectively prevent mechanical ventilation-induced diaphragmatic dysfunction
Maintenance of spontaneous breathing at an intensity of 60%–80% may effectively prevent mechanical ventilation-induced diaphragmatic dysfunction Open
Controlled mechanical ventilation (CMV) can cause diaphragmatic motionlessness to induce diaphragmatic dysfunction. Partial maintenance of spontaneous breathing (SB) can reduce ventilation-induced diaphragmatic dysfunction (VIDD). However,…
View article: Neutrophil/lymphocyte ratio is helpful for predicting weaning failure: a prospective, observational cohort study
Neutrophil/lymphocyte ratio is helpful for predicting weaning failure: a prospective, observational cohort study Open
NLR may be a useful marker for predicting weaning failure, and weaning at NLR >11 might be considered with caution. Further study with a larger sample size and with weaning outcome as a variable of concern is warranted. Trial registration:…
View article: Associations of Pulmonary Fibrosis with Peripheral Blood Th1/Th2 Cell Imbalance and EBF3 Gene Methylation in Uygur Pigeon Breeder’s Lung Patients
Associations of Pulmonary Fibrosis with Peripheral Blood Th1/Th2 Cell Imbalance and EBF3 Gene Methylation in Uygur Pigeon Breeder’s Lung Patients Open
Background/Aims Pigeon breeder’s lung (PBL) results from Th1/Th2 cell imbalance. B cells inhibit the immune activity of Th1, and EBF3 is a key B cell factor. This study explored the relationship between EBF3 and Th1/Th2 imbalance in chroni…
View article: The correlation between pulmonary fibrosis and methylation of peripheral <i>Smad3</i> in cases of pigeon breeder’s lung in a Chinese Uygur population
The correlation between pulmonary fibrosis and methylation of peripheral <i>Smad3</i> in cases of pigeon breeder’s lung in a Chinese Uygur population Open
Smad3 is a key protein in the transforming growth factor-beta (TGF-β)/Smad signaling pathway, which is involved in fibrosis in many organs. We investigated the relationship between Smad3 gene methylation and pulmonary fibrosis in pigeon br…
View article: Abnormal bone mineral density and bone turnover marker expression profiles in patients with primary spontaneous pneumothorax
Abnormal bone mineral density and bone turnover marker expression profiles in patients with primary spontaneous pneumothorax Open
It had lower bone mineral density in PSP patients. Bone formation marker PINP, N-MID and bone resorption marker b-CTX, TRACP5b were upregulated in PSP patients. 25-OH VD expression was relatively low in this population of PSP patients. Age…
View article: Simvastatin promotes alveolar epithelial cell proliferation and attenuates cigarette smoke-induced emphysema in rats
Simvastatin promotes alveolar epithelial cell proliferation and attenuates cigarette smoke-induced emphysema in rats Open
Current treatments for chronic obstructive pulmonary disease (COPD) cannot reverse the pathological process of the disease, therefore, the development of novel agents and strategies for COPD treatment is required. The aim of the present st…