Sen Pathak
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View article: The Role of Molecular Docking in Modern Drug Discovery and Development: A Comprehensive Review
The Role of Molecular Docking in Modern Drug Discovery and Development: A Comprehensive Review Open
Molecular docking is an essential computational technique widely used in drug discovery to predict the interaction between small molecules and their protein targets. This review presents a detailed examination of molecular docking, includi…
View article: Data from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Data from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
Purpose: Translocation renal cell carcinoma (tRCC) is a rare subtype of kidney cancer involving the TFEB/TFE3 genes. We aimed to investigate the genomic and epigenetic features of this entity.Experimental Design: Cytogenomic analysis was c…
View article: Supplementary Tables 1 - 3 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Supplementary Tables 1 - 3 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
PDF file - 86K, Supplementary Table 1. Clinicopathologic characteristics of patients with confirmed Translocation RCC Supplementary Table 2: Clinicopathological features of TFE3 overexpressing renal cell carcinoma with no TFE3 translocatio…
View article: Data from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Data from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
Purpose: Translocation renal cell carcinoma (tRCC) is a rare subtype of kidney cancer involving the TFEB/TFE3 genes. We aimed to investigate the genomic and epigenetic features of this entity.Experimental Design: Cytogenomic analysis was c…
View article: Supplementary Figure 1 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Supplementary Figure 1 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
PDF file - 135K, Supplementary Figure 1. Flow chart for patient selection and different tested performed.
View article: Supplementary Figure 1 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Supplementary Figure 1 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
PDF file - 135K, Supplementary Figure 1. Flow chart for patient selection and different tested performed.
View article: Supplementary Figure 2 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Supplementary Figure 2 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
PDF file - 166K, Supplementary Figure 2. A, virtual karyotyping of the UOK109 cell line shows the following copy number alterations: +2, +5q,+7,-8p,+8q,-9p,+16, which are consistent with pRCC karyotyping. B, virtual karyotyping of the UOK1…
View article: Supplementary Figure 3 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Supplementary Figure 3 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
PDF file - 130K, Supplementary Figure 3. A) Gene Set enrichment Analysis (GSEA) showing enrichment of mitosis pathways in cases with 17q gain. B, Ingenuity Pathway Analysis of genes expressed differently between samples with partial 17q ga…
View article: Supplementary Figure Legends from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Supplementary Figure Legends from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
PDF file - 62K
View article: Supplementary Figure Legends from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Supplementary Figure Legends from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
PDF file - 62K
View article: Supplementary Figure 3 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Supplementary Figure 3 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
PDF file - 130K, Supplementary Figure 3. A) Gene Set enrichment Analysis (GSEA) showing enrichment of mitosis pathways in cases with 17q gain. B, Ingenuity Pathway Analysis of genes expressed differently between samples with partial 17q ga…
View article: Supplementary Tables 1 - 3 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Supplementary Tables 1 - 3 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
PDF file - 86K, Supplementary Table 1. Clinicopathologic characteristics of patients with confirmed Translocation RCC Supplementary Table 2: Clinicopathological features of TFE3 overexpressing renal cell carcinoma with no TFE3 translocatio…
View article: Supplementary Figure 2 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma
Supplementary Figure 2 from Genomic Heterogeneity of Translocation Renal Cell Carcinoma Open
PDF file - 166K, Supplementary Figure 2. A, virtual karyotyping of the UOK109 cell line shows the following copy number alterations: +2, +5q,+7,-8p,+8q,-9p,+16, which are consistent with pRCC karyotyping. B, virtual karyotyping of the UOK1…
View article: Data from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
Data from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis Open
Human bone stromal cells, after three-dimensional coculture with human prostate cancer (PCa) cells in vitro, underwent permanent cytogenetic and gene expression changes with reactive oxygen species serving as mediators. The evolved stromal…
View article: Supplementary Figures from Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer
Supplementary Figures from Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer Open
Supplementary Figures from Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer
View article: Supplementary Legends 1-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
Supplementary Legends 1-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis Open
Supplementary Legends 1-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
View article: Supplementary Data 6-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
Supplementary Data 6-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis Open
Supplementary Data 6-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
View article: Data from Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer
Data from Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer Open
The deregulated expression of cyclin E as measured by the overexpression of its low molecular weight (LMW) isoforms is a powerful predictor of poor outcome in patients with breast cancer. The mechanism by which these LMW forms give tumor c…
View article: Supplementary Data 1-5 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
Supplementary Data 1-5 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis Open
Supplementary Data 1-5 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
View article: Data from Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer
Data from Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer Open
The deregulated expression of cyclin E as measured by the overexpression of its low molecular weight (LMW) isoforms is a powerful predictor of poor outcome in patients with breast cancer. The mechanism by which these LMW forms give tumor c…
View article: Supplementary Data 6-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
Supplementary Data 6-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis Open
Supplementary Data 6-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
View article: Supplementary Legends 1-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
Supplementary Legends 1-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis Open
Supplementary Legends 1-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
View article: Data from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
Data from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis Open
Human bone stromal cells, after three-dimensional coculture with human prostate cancer (PCa) cells in vitro, underwent permanent cytogenetic and gene expression changes with reactive oxygen species serving as mediators. The evolved stromal…
View article: Supplementary Data 1-5 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
Supplementary Data 1-5 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis Open
Supplementary Data 1-5 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
View article: Supplementary Figures from Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer
Supplementary Figures from Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer Open
Supplementary Figures from Tumor-Specific Low Molecular Weight Forms of Cyclin E Induce Genomic Instability and Resistance to p21, p27, and Antiestrogens in Breast Cancer
View article: Chromosome size affects sequence divergence between species through the interplay of recombination and selection
Chromosome size affects sequence divergence between species through the interplay of recombination and selection Open
The structure of the genome shapes the distribution of genetic diversity and sequence divergence. To investigate how the relationship between chromosome size and recombination rate affects sequence divergence between species, we combined e…
View article: 3D genomics across the tree of life reveals condensin II as a determinant of architecture type
3D genomics across the tree of life reveals condensin II as a determinant of architecture type Open
Organismal evolution of the 3D genome The conformation of chromosomes within the nucleus can reflect a cell's type or state. However, studies of the conservation and evolutionary history of the mechanisms regulating genome structure across…
View article: 3D genomics across the tree of life reveals condensin II as a determinant of architecture type
3D genomics across the tree of life reveals condensin II as a determinant of architecture type Open
GAMinG script (python) and sequence file (.dat) to prepare files to run molecular dynamics in GROMACS (see ndb.rice.edu for more info regarding how to run the simulations). Two .hic maps and two sample trajectory files for high and low len…
View article: 3D genomics across the tree of life reveals condensin II as a determinant of architecture type
3D genomics across the tree of life reveals condensin II as a determinant of architecture type Open
GAMinG script (python) and sequence file (.dat) to prepare files to run molecular dynamics in GROMACS (see ndb.rice.edu for more info regarding how to run the simulations). Two .hic maps and two sample trajectory files for high and low len…