Chongsen Zang
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View article: Association between cumulative average triglyceride glucose-body mass index and the risk of CKD onset
Association between cumulative average triglyceride glucose-body mass index and the risk of CKD onset Open
Background Chronic kidney disease (CKD) has become a significant global public health challenge, which was reported to be highly correlated with the triglyceride glucose-body mass index (TyG-BMI). Nevertheless, literature exploring the ass…
View article: Renalase regulates renal tubular injury in diabetic nephropathy via the p38MAPK signaling pathway
Renalase regulates renal tubular injury in diabetic nephropathy via the p38MAPK signaling pathway Open
Diabetic nephropathy (DN) is an important complication of diabetes and the leading cause of end‐stage renal disease globally. Renal tubular damage occurs to varying degrees in the early stages of DN prior to glomerular damage. Renalase (RN…
View article: Diagnostic value of neutrophil gelatinase-associated lipocalin in diabetic nephropathy: a meta-analysis
Diagnostic value of neutrophil gelatinase-associated lipocalin in diabetic nephropathy: a meta-analysis Open
Purpose: This meta-analysis aimed to determine the diagnostic performance of neutrophil gelatinase-associated lipocalin (NGAL) in diabetic nephropathy (DN). Methods: We searched the PubMed, Embase, Wanfang, and China National Knowledge Inf…
View article: Expression, purification and biological effect of a novel single chain Fv antibody and protamine fusion protein for the targeted delivery of siRNAs to FGFR3 positive cancer cells
Expression, purification and biological effect of a novel single chain Fv antibody and protamine fusion protein for the targeted delivery of siRNAs to FGFR3 positive cancer cells Open
Background: Gain-of-function of fibroblast growth factor receptor 3 (FGFR3) is involved in the pathogenesis of many tumors. More and more studies have focused on the potential usage of therapeutic single-chain Fv (ScFv) antibodies against …
View article: 12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance
12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance Open
(1) Background: 12-lipoxygenase (12-LO) is involved in the development of diabetic nephropathy (DN). In the present study, we investigated whether 12-LO inhibition may ameliorate type-2 DN (T2DN) by interfering with insulin resistance (IR)…