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View article: Synthesis and Characterization of Memantine-Loaded Niosomes for Enhanced Alzheimer’s Disease Targeting
Synthesis and Characterization of Memantine-Loaded Niosomes for Enhanced Alzheimer’s Disease Targeting Open
Background/Objectives: Over the past 25 years, numerous biological molecules, like recombinant lysosomal enzymes, neurotrophins, receptors, and therapeutic antibodies, have been tested in clinical trials for neurological diseases. However,…
View article: Morphological, anatomical, and bioactive properties of Hypericum scabrum L.: effects on diabetes mellitus, Alzheimer’s disease, and HDFa fibroblasts and U87-MG cancer cells
Morphological, anatomical, and bioactive properties of Hypericum scabrum L.: effects on diabetes mellitus, Alzheimer’s disease, and HDFa fibroblasts and U87-MG cancer cells Open
Diabetes mellitus (DM) and cancer are multifactorial diseases with significant health consequences, and their relationship with aging makes them particularly challenging. Epidemiological data suggests that individuals with DM are more susc…
View article: Targeting Alzheimer's disease with novel dual-function 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamide derivatives
Targeting Alzheimer's disease with novel dual-function 3,5-diaryl-4,5-dihydro-1H-pyrazole-1-carbothioamide derivatives Open
In the field of medicinal chemistry, the versatility of the thiosemicarbazone scaffold makes it a promising platform for the development of next-generation pharmaceuticals. In this paper the thiosemicarbazone scaffold was explored to obtai…
View article: Combined Metabolic Activators with Different NAD+ Precursors Improve Metabolic Functions in the Animal Models of Neurodegenerative Diseases
Combined Metabolic Activators with Different NAD+ Precursors Improve Metabolic Functions in the Animal Models of Neurodegenerative Diseases Open
Background: Mitochondrial dysfunction and metabolic abnormalities are acknowledged as significant factors in the onset of neurodegenerative disorders such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). Our research has demonstra…
View article: Drug Synergism of Anticancer Action in Combination with Favipiravir and Paclitaxel on Neuroblastoma Cells
Drug Synergism of Anticancer Action in Combination with Favipiravir and Paclitaxel on Neuroblastoma Cells Open
Background and Objectives: Favipiravir (FPV) is an antiviral medication and has an inhibitory effect on Cytochrome P450 (CYP2C8) protein, which is mainly involved in drug metabolism in the liver, and the expression of this gene is known to…
View article: Serum catestatin levels in patients with acne vulgaris: single-center prospective study
Serum catestatin levels in patients with acne vulgaris: single-center prospective study Open
Recent studies showed that antimicrobial peptides (AMPs) are essential in the pathogenesis of acne vulgaris. This study aims to investigate serum catestatin levels, one of the AMPs, in acne vulgaris patients and focuses on the change in se…
View article: Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson’s Disease Model
Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson’s Disease Model Open
Monoamine oxidase B (MAO-B) is an enzyme that metabolizes several chemicals, including dopamine. MAO-B inhibitors are used in the treatment of Parkinson’s Disease (PD), and the inhibition of this enzyme reduces dopamine turnover and oxidat…
View article: Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes
Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes Open
Complications of chronic non-healing wounds led to the emergence of nanotechnology-based therapies to enhance healing, facilitate tissue repair, and prevent wound-related complications like infections. Here, we design alpha lipoic acid (AL…
View article: RETRACTED: Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases
RETRACTED: Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases Open
Overall, we showed that CMA administration significantly improved behavioural scores in parallel with the neurohistological outcomes in the AD and PD animal models and is a promising treatment for improving the metabolic parameters and bra…
View article: Combined Metabolic Activators Improve Cognitive Functions in Alzheimer’s Disease Patients: A Randomised, Double-Blinded, Placebo-Controlled Phase-II Trial
Combined Metabolic Activators Improve Cognitive Functions in Alzheimer’s Disease Patients: A Randomised, Double-Blinded, Placebo-Controlled Phase-II Trial Open
Background Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administrated Combined Metabolic Activators (CMA) to the AD rat model and observed that administra…
View article: Combined Metabolic Activators Improves Cognitive Functions in Alzheimer’s Disease Patients
Combined Metabolic Activators Improves Cognitive Functions in Alzheimer’s Disease Patients Open
Background:Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administrated Combined Metabolic Activators (CMA) to the AD rat model and observed that administra…
View article: Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer’s Disease Treatment
Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer’s Disease Treatment Open
The search for an innovative and effective drug delivery system that can carry and release targeted drugs with enhanced activity to treat Alzheimer’s disease has received much attention in the last decade. In this study, we first designed …
View article: In vitro evaluation of selective cytotoxic activity of Chaerophyllum macropodum Boiss. on cultured human neuroblastoma SH-SY5Y cells
In vitro evaluation of selective cytotoxic activity of Chaerophyllum macropodum Boiss. on cultured human neuroblastoma SH-SY5Y cells Open
Neuroblastoma is the most common solid tumor in children. New treatment approaches are needed because of the harmful side effects and costs of the methods used in the treatment of neuroblastoma. Medicinal and aromatic plants are important …
View article: Combined Metabolic Activators Improves Cognitive Functions in Alzheimer’s Disease
Combined Metabolic Activators Improves Cognitive Functions in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. Here, we analysed the brain transcriptomics data of more than 600 AD patients using genome-scale metabolic models and pro…