Senlin Zhao
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View article: Cancer-associated adipocytes promote peritoneal metastasis of colorectal signet ring cell carcinoma via FABP4 induction
Cancer-associated adipocytes promote peritoneal metastasis of colorectal signet ring cell carcinoma via FABP4 induction Open
CAA-derived exosomal signaling promotes SRCC aggressiveness through FABP4-mediated fatty acid metabolic reprogramming, identifying FABP4 as a potential therapeutic target for peritoneal metastasis in colorectal SRCC.
View article: Huaier overcomes tumor-induced immunosuppression in colorectal cancer by activating MHC I and CD8+ T cells
Huaier overcomes tumor-induced immunosuppression in colorectal cancer by activating MHC I and CD8+ T cells Open
Our findings establish Huaier as a multifaceted immunoadjuvant that bridges innate and adaptive immunity in CRC. This natural agent offers a translatable strategy to enhance the therapeutic efficacy of existing immunotherapies of CRC patie…
View article: Author Correction: The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer
Author Correction: The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer Open
View article: The lncRNA MIR181A1HG in extracellular vesicles derived from highly metastatic colorectal cancer cells promotes liver metastasis by remodeling the extracellular matrix and recruiting myeloid-derived suppressor cells
The lncRNA MIR181A1HG in extracellular vesicles derived from highly metastatic colorectal cancer cells promotes liver metastasis by remodeling the extracellular matrix and recruiting myeloid-derived suppressor cells Open
Background Colorectal liver metastasis (CRLM) is the main cause of death in colorectal cancer (CRC) patients worldwide. In the initial stage of metastasis, primary tumors provide the necessary conditions for metastasis by shaping the local…
View article: WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis
WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis Open
View article: Traditional Medicine Huaier Overcomes Immunosuppressive Microenvironments in Colorectal Cancer by Augmenting Mhc I-Dependent Antigen Presentation and Reinvigorating T Cell Cytotoxicity
Traditional Medicine Huaier Overcomes Immunosuppressive Microenvironments in Colorectal Cancer by Augmenting Mhc I-Dependent Antigen Presentation and Reinvigorating T Cell Cytotoxicity Open
View article: HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis
HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis Open
View article: Mitochondrial genome transfer drives metabolic reprogramming in adjacent colonic epithelial cells promoting TGFβ1-mediated tumor progression
Mitochondrial genome transfer drives metabolic reprogramming in adjacent colonic epithelial cells promoting TGFβ1-mediated tumor progression Open
View article: Retraction: MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4
Retraction: MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4 Open
View article: Function and mechanism of MCM8 in the development and progression of colorectal cancer
Function and mechanism of MCM8 in the development and progression of colorectal cancer Open
View article: AF9 sustains glycolysis in colorectal cancer via H3K9ac‐mediated PCK2 and FBP1 transcription
AF9 sustains glycolysis in colorectal cancer via H3K9ac‐mediated PCK2 and FBP1 transcription Open
Background The tumourigenesis of various cancers is influenced by epigenetic deregulation. Among 591 epigenetic regulator factors (ERFs) examined, AF9 showed significant inhibition of malignancy in colorectal cancer (CRC) based on our woun…
View article: Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches Open
Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits are minimal in CRLM. The complex…
View article: BST2 induced macrophage M2 polarization to promote the progression of colorectal cancer
BST2 induced macrophage M2 polarization to promote the progression of colorectal cancer Open
Background: Tumor-associated macrophages (TAMs) are one of the most prominent tumor-infiltrating immune cells in the tumor microenvironment (TME) of CRC and play a vital role in the progression of CRC. BST2 was predicted to be assoc…
View article: Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications
Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications Open
View article: A Hypoxia-Related lncRNA Signature Correlates with Survival and Tumor Microenvironment in Colorectal Cancer
A Hypoxia-Related lncRNA Signature Correlates with Survival and Tumor Microenvironment in Colorectal Cancer Open
The hypoxic tumor microenvironment and long noncoding RNAs (lncRNAs) are pivotal in cancer progression and correlate with the survival outcome of patients. However, the role of hypoxia-related lncRNAs (HRLs) in colorectal cancer (CRC) deve…
View article: Construction of a prognostic glycolysis‐related lncRNA signature for patients with colorectal cancer
Construction of a prognostic glycolysis‐related lncRNA signature for patients with colorectal cancer Open
Aerobic glycolysis is a common metabolic phenotype in tumors that helps cancer cells adjust to severe living conditions and can aid metastasis in several types of carcinomas, including colorectal cancer (CRC). Long non‐coding RNAs (lncRNAs…
View article: Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment
Highly‐metastatic colorectal cancer cell released miR‐181a‐5p‐rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment Open
Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC‐related mortality, and is typically caused by interactions between CRC cells and the tumour microenvironment (TME) in the liver. However, the molecular mechanisms…
View article: RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA
RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA Open
View article: LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit
LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit Open
View article: RNA-Binding Protein IMP3 is a Novel Regulator of MEK1/ERK Signaling Pathway in the Progression of Colorectal Cancer through the Stabilization of MEKK1 mRNA
RNA-Binding Protein IMP3 is a Novel Regulator of MEK1/ERK Signaling Pathway in the Progression of Colorectal Cancer through the Stabilization of MEKK1 mRNA Open
Background MEK1/ERK signaling pathway plays an important role in most tumor progression, including colorectal cancer (CRC), however, MEK1-targeting therapy has little effective in treating CRC patients, indicating there may be a complex me…
View article: UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer
UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer Open
UPF1 is proved to dysregulate in multiple tumors and influence carcinogenesis. However, the role of UPF1 in oxaliplatin resistance in colorectal cancer (CRC) remains unknown. In our study, UPF1 is upregulated in CRC in mRNA and protein lev…
View article: Correction to: Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer
Correction to: Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer Open
View article: UPF1 Promotes Chemoresistance to Oxaliplatin Through Maintenance of Stemness by Increasing Phosphorylated TOP2A in Colorectal Cancer.
UPF1 Promotes Chemoresistance to Oxaliplatin Through Maintenance of Stemness by Increasing Phosphorylated TOP2A in Colorectal Cancer. Open
Background : UPF1 is proved to dysregulate in multiple tumors and influence carcinogenesis. However, the role of UPF1 on oxaliplatin resistance in colorectal cancer (CRC) remains unknown. Methods : Firstly, we investigated the clinical rel…
View article: An insight into small extracellular vesicles: Their roles in colorectal cancer progression and potential clinical applications
An insight into small extracellular vesicles: Their roles in colorectal cancer progression and potential clinical applications Open
Colorectal cancer (CRC) is one of the most common cancers and a leading cause of mortality worldwide. Small extracellular vesicles (sEVs) are nano‐sized extracellular vesicles containing a variety of bioactive molecules, such as nucleic ac…
View article: Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer
Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer Open
View article: Predictive Role of Biopsy Based Biomarkers for Radiotherapy Treatment in Rectal Cancer
Predictive Role of Biopsy Based Biomarkers for Radiotherapy Treatment in Rectal Cancer Open
Background and Purpose: Radiation therapy has long been contemplated as an important mode in the treatment of rectal cancer. However, there are few ideal tools available for clinicians to make a radiotherapy decision at the time of diagnos…
View article: Additional file 18 of Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer
Additional file 18 of Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer Open
Additional file 18: Table S3. Deregulated miRNA between stage I and stage IV colon cancer from TCGA data set.
View article: Additional file 23 of Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer
Additional file 23 of Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer Open
Additional file 23: Table S8. The top 191 miR-934-correlated genes in TCGA cohorts.
View article: Dedifferentiation of hepatocellular carcinoma: molecular mechanisms and therapeutic implications.
Dedifferentiation of hepatocellular carcinoma: molecular mechanisms and therapeutic implications. Open
Hepatocellular carcinoma (HCC) is a common cancer with high morbidity and mortality. Poorer differentiation status indicates worse prognosis of HCC patients. Regain of better differentiation status may improve the prognosis. Differentiatio…
View article: Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation
Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation Open
PTI improves OS and RFS of the transplant HCC patients at a high risk for post-transplant death and tumor recurrence, which is attributed to suppressive effect of PTI on HCC recurrence.